ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04370.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTSeveral reports have suggested that cyclic guanosine 3′‐5′ monophosphate (cGMP) and cyclic 3′‐5′ adenosine monophosphate (cAMP) are involved in the regulation of cellular proliferation. Following our previous reports on the cAMP system in human brain tumors, we decided to investigate the cGMP system in the same pathological tissues by studying the activity of guanylate cyclase and cGMP‐phosphodiesterase (cGMP‐PDE). We found that the activity of both enzymes is lower in neurinomas and glioblastomas than in meningiomas or in normal cerebral cortex. Furthermore, the subcellular distribution of guanylate cyclase in human cerebral cortex differs from that of neurinomas and glioblastomas. On the basis of such ob servations we have discussed the possibility that the regulatory mechanism of the enzymes related to the cyclic nucleotide metabolism is altered

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04371.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTNeuropathological findings were studied in 74 patients with drugresistant temporal lobe epilepsy who underwent unilateral temporal lobe resection in 1960–1969 in Denmark. In 60 per cent of the patients a well‐defined neuropathological abnormality was revealed (i. e. 13 cases of focal lesions, including four small tumours, 21 cases of gliosis, and 10 cases of perivascular infiltration), in 23 per cent the findings were either questionably abnormal or without structural abnormality, while in the last 18 per cent sequelae of a previous operation dominated the histology. the general trend was for the postoperative clinical outcome to be better, the more specific and circumscribed the histological abnormality. There was no correlation between the neuropathological findings and the preoperative types of seizures. Postoperative recurrence of seizures was more often observed in patients with gliosis than in those with other histological diagnoses. A positive correlation existed between a history of cerebral infection and the presence of perivascular lymphocytic and histiocytic infiltration, and gliosis was a frequent finding in patients with epilepsy of unknown aetiology. No other significant correlation was found between the neuropathological abnormalities and the clinical, hereditary, aetiological, and social aspe

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04372.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTIn 152 consecutively selected patients with detrusor hyperreflexia (DH) 96 (63 per cent) had neurological disorders. Thirty‐two patients did not show any primary neurological or urological cause for DH. This group was chosen to elucidate the evaluation of possible neurological symptoms in relation to the urological symptomatology. Nine had died and one failed to appear to the neurological examination. Twelve (63 per cent) of the 22 examined patients showed signs of lesions in different parts of the central nervous system, particularly cerebrovascular diseases and myeloneuropathy. Six had had neurological symptoms for years. In two the urological symptoms were first to appear. In the group with no neurological complaints the urological symptoms had existed for 2–30 years. No essential difference was found in the degree of voiding disturbance whether or not neurological signs were disclosed. It is concluded that the discovery of DH should be followed by a neurological examination to disclose further signs of lesions in CNS. Likewise, an extended urological examination with demonstration of DH might help in the evaluation of an obscure neurological dise

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04373.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTImmunoglobulin concentrations were determined by radial immunodiffusion in sera from 15 epileptic patients before and during phenytoin therapy. Three reaction patterns were recorded: Two patients developed IgA deficiency (<0.05 mg/ml) during the first 3–4 months of treatment. Both patients also had a decrease in serum IgG and IgM, but no significant fall or increase in serum IgE. the IgA deficiency state was apparently reversible, since normalization of serum levels occurred after withdrawal of phenytoin. Five patients developed a 35–80 per cent reduction in serum IgA. In these patients, the decline in serum levels of IgG and IgM was inconsistent. Eight patients showed no significant fluctuations in serum immunoglobulins during phenytoin treatment. When a fall in serum IgA occurred, it did not correspond to a fall in serum or in red cell folate. Mean serum IgG was lower (9.37 mg/ml) in epileptic patients who had taken phenytoin for<1 year and had a low IgA, than in patients who had taken phenytoin for 10 years or more (11.50 mg/

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04374.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe occurrence of dementia in patients with Parkinson's disease was studied in a Parkinsonian population consisting of all traceable patients residing in a defined area. the prevalence of dementia was found to be 29 per cent in 444 patients studied. the frequency of dementia increased with advancing age and the patients showing signs of clinical arteriosclerosis were more often demented than the patients without arteriosclerosis. There was, however, an evident association between the stage of the disease and the frequency of dementia. the most severely disabled patients displayed dementia more often than the mildly affected, both among the patients with and without arteriosclerosis. the demented patients showed significantly more severe rigidity and hypokinesia when compared with the non‐demented. Increasing severity of rigidity and hypokinesia, in particular, was found to have a positive correlation with the degree of dementia. the association between dementia and the degree of motor involvement is considered to suggest the role of subcortical structures in the pathophysiology of dementia in Parkinson's diseas

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04375.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThein vitroprotein synthesis by polyribosomes extracted from biopsied muscle (vastus lateralis) was studied in 47 known carriers, 87 possible carriers and in 60 normal females. A significant increase in specific activity of monomeric ribosomes, total polyribosomes and collagen synthesis was found in 46 (97.8 per cent) known carriers and 47 (54 per cent) possible carriers of Duchenne muscular dytrophy. the latter showed an increase in ribosomal protein synthesis in 10 (52.6 per cent) of 19 mothers of isolated cases, 31 (53.3 per cent) of 58 sisters, and 6 (60 per cent) of 10 other female relatives. Serum creatine phosphokinase was increased in 30 (63.8 per cent) of 47 known carriers.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04376.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe grasp reflex of the foot and related phenomena were examined in six subjects with no abnormalities of deep tendon or plantar (and related) reflexes 6 to 10 years after cerebral comissurotomy. In all subjects they were more marked on the same side as the more damaged hemisphere. These tonic phenomena seem to be facillitated by sitting and standing postures. Practical and theoretical implications of the tonic foot responses in the absence of similar phenomena of the hand are discussed.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04377.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04378.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Griffin, C. J.&Harris, R.: the Temporomandibular Joint SyndromeJohn McFie: Assessment of Organic Intellectual Impairment

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04379.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY