摘要:

ABSTRACTVarious characteristics of 128 men and 85 women, less than 50 years old and suffering from ischaemic cerebrovascular disease, were analysed. Cigarette smoking was 1.5 times as common in men and 3 times as common in women as in an average Finnish population of the same age. The prevalence of the use of oral contraceptive at the time of the cerebrovascular accident was 2.5 times as high as for women of childbearing age in South Finland. The average relative weight of men and women did not differ from the “ideal weight” of the Finnish population, but overweight persons (more than 110 % of the ideal weight) were twice as numerous as underweight persons (less than 90 % of the ideal weight). Hypertension was in men, about 2.5 times and in women, 1.5 times as frequent as in a large Finnish population study but these prevalences must be regarded as underestimates because hospitalization tends to reduce blood pressure values. Electrocardiographic abnormalities were encountered frequently. Compared with the results of a population study for men in the 40‐49 years age group Q‐waves were encountered 7.5 times as frequently, S‐T depression 12 times, T‐wave negativity 4 times and tall R‐waves twice as frequently. It seems that cigarette smoking, use of oral contraceptives, hypertension and electrocardiographic abnormalities are associated with increased risk of cerebrovascular disease in young persons. The role of overweig

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01314.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTThe material analysed consisted of 213 patients younger than 50 years of age who were suffering from ischaemic cerebrovascular disease. Serum cholesterol values were measured in 202 patients (95 per cent of all cases) and triglycerides were measured in 181 patients (85 percent of all cases), and the values were then compared with those of a Finnish population study. There was no difference in cholesterol values between the patients and the population. The triglyceride values of men aged 40 to 49 years and of women aged 30 to 39 and 40 to 49 years suffering from ischaemic cerebrovascular disease were significantly higher than those obtained from the population study. Thus it seems unlikely that cholesterol values have any association with ischaemic stroke occurring before the age of 50 years whereas the high triglyceride values may be associated with an increased risk of ischaemic cerebrovascular disease at a relatively young age.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01315.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTRoutine brain scanning, using a scintillation camera and Tc99m pertechnetate, was performed on 42 patients with an intracranial arteriovenous malformation. Thirty‐two (76 %) of them had a positive brain scan, and the location of increased uptake correlated well with the localisation of the malformation found in carotid angiography. Large malformations were detected significantly better than small malformations. The largest malformations with negative brain scanning were located in the posterior fossa and temporobasally. In 18 cases (43 %) one or several “tails” of increased activity on the scan were seen sprouting from the local uptake. These tails corresponds to the afferent and efferent vessels of the malformation seen in carotid angiography. Such tails of increased activity are highly suggestive of intracranial arteriovenous malform

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01316.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTTwenty‐five patients with acute monosymptomatic optic neuritis were examined. Of primary interest were the changes in the cerebrospinal fluid as a possible indicator of future development of multiple sclerosis. The most common abnormality was mononuclear leuco‐cytosis which occurred in 60 %. Other abnormalities were infrequent, which is in sharp contrast to findings in definite cases of multiple sclerosis. The total protein concentration was elevated in 6 of 25 cases (24 %) and the relative immunoglobulin G concentration was elevated in 4 cases (16 %). On agar gel electrophoresis bands in the gamma globulin region were found in 6 cases (24 %). Three patients have so far developed a definite multiple sclero

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01317.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTStatistical analysis of clinical data (sex, clinical stage, and age of the disease) and biological data (CSF total protein, albumin and gammaglobulins by electrophoresis, lymphocytes count) from a population of 326 MS patients (115 men and 211 women) suggests that MS is a two‐phase disease. The early phase is probably an intermittent and intrathecal synthesis of antibodies linked to a lymphocytic pleiocytosis: this acute intermittent process may represent a local immuno‐logical reaction against a virus. The second phase, on the other hand, is a continuous synthesis of antibodies with simultaneous increase of albumin in CSF and disappearance of any lymphocytic pleiocytosis: the probability being in favour of a synthesis of antibodies out of the CNS (in peripheral lymphoid organs), in other words, of an autoimmune proc

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01318.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTThe effect of slow intravenous infusion of luteinizing hormone‐releasing hormone (LH‐RH) on serum LH was studied in 58 patients with anatomically verified hypothalamo‐pituitary disorders as well as in control groups. Normal responses to the LH‐RH test were found in 15 out of 15 cases with intrasellar pituitary tumours and in five out of six cases after transsphenoidal surgery for an intrasellar pituitary tumour. Twenty‐one out of 25 patients where a pituitary tumour with both supra‐ and intrasellar extension had been removed had pathological responses to the test. All eight patients with hypothalamic disorders, mainly tumours not directly influencing the pituitary, gave normal responses to the LH‐RH tests. Out of four patients with hypothalamopituitary malformations a pathological response to the LH‐RH infusion was found in three cases and a normal response in one case. The increase of serum LH after LH‐RH infusion was pronounced and rather constant in males and post‐menopausal women. It was more difficult to evaluate a “normal” test response in women of fertile ages because of the great variations during the different menstrual phases. It is concluded that the LH‐RH test may be of importance in the investigation of patients with suspected tumours of the pituitary as well as for differential diagnosis between hypothalamic and pituitary disorders

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01319.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTSupported by the “MS‐Schwerpunktsprogramm der Deutschen Forschungsgemeinschaft (Dr. Fischer‐Bosch‐Stiftung)” a special project was started to register patients with multiple sclerosis. In the multicentric study 14 hospitals participated. The clinical data had to be standardized in order to gain comparable results. For this purpose a documentation sheet was developed. The experiences with the optical mark reader documentation system were favourable. The frequency of certain signs and symptoms and their combinations in the 3 groups of diagnostic classification—definite, probable, possible—were presented. A greater statistical material gained by this method will give standardized criteria of the disease and thus enable a computerized diagnosis of multi

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01320.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTA family having paramyotonia congenita was observed through following up a few members over a period of 19 years. The natural history of the syndrome is outlined. This bears out the character of the disease as an entity fully independent of other myotonic conditions. At later age, an increased stiffening of desmogenic nature occurs in the wrist and finger joints. Four members got paralysis agitans. The significance of this feature is discussed. One family member came to post‐mortem. In the central nervous system, none but the normal age‐induced alterations were observed. A discussion is given of the changes in the muscle fibres. These did not show any clearly preferred localisation. In the eye, atrophy of the ciliary body was fo

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01321.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTThe places of birth of 1,000 Finnish patients with multiple sclerosis (MS) were located according to the population statistics of 1930. The highest frequency of the disease was found in a small district, Jalasjärvi, composed of 6 rural communes in the western high‐risk area of the country. One animal disease, nutritional muscular dystrophy of the cattle (NMD), appeared to be very common in the same western area and, in 1970, its highest frequency was also found in the Jalasjärvi district. Some western accumulation was found in the cases of two viruses of cereals, European wheat striate mosaie virus (EWSMV) and oat sterile dwarf virus (OSDV), but both of them were rare in the southwestern part of Finland where the prevalence of MS was h

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01322.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

ABSTRACTRoutine electroencephalography was performed on 58 patients with an intracranial arteriovenous malformation. Local abnormal EEG findings were observed in 23 (40 %) of them, 15 (26 %) had a general abnormality, and in 20 (34 %) the EEG was normal. In two patients with a local abnormality the abnormality was contralateral to the AVM. There was no relation between EEG abnormality and age of patients or duration of the symptoms. The size and radiological density of the AVM were not related with the frequency of EEG abnormality, nor were any differences seen in the distribution of findings between the non‐haemorrhagic, subarachnoid haemorrhage and intracerebral haemorrhage groups. In patients with a history of epileptic seizures abnormality of the EEG was more frequent (p<0.05) than in those with no epileptic seizures. Parietal and temporal AVMs combined had a higher frequency (p<0.001) of local EEG abnormalities than in those patients in whom the AVM was occipital, central or in the posterior fossa. EEG as a screening method for intracranial AVM is noted to reveal only 62% of those AVMs found by brain scanning. On the other hand, half of the patients in whom scanning failed (due to small size or temporal location of the AVM) the EEG showed a local abnormalit

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1973.tb01323.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY