摘要:

Possible sensitisation of peripheral blood mononuclear cells from multiple sclerosis (MS) patients was studied in the presence of both normal and MS brain subcellular fractions. Myelin, synaptosomal and microsomal fractions and myelin basic protein were prepared by sucrose density gradient centrifugation from normal and MS brain. These preparations were added to mononuclear cell microcultures from the peripheral blood of nine acute and six chronic MS patients, 10 patients with other neurological diseases and 10 normal subjects. There was no significant increment in the peripheral blood mononuclear cell transformation of any of the acute MS patients with any of the fractions. Therefore there is no evidence that immunity to antigens in any of the fractions of MS or normal brain is of primary pathogenetic importance. A small increment in peripheral blood mononuclear cell transformation in the presence of several fractions was observed in two of six chronic MS patients, which might indicate the development of a secondary immune response after prolonged disease.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03074.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Since the cyclic nucleotides (CN) adenosine 3′,5′‐monophosphate (cAMP) and guanoside 3′,5′‐monophosphate (cGMP) are involved in the regulation of cell proliferation and tumor growthin vitro, a study was made of the levels of these compounds in the lumbar cerebrospinal fluid (CSF) of 20 patients with intracranial and spinal tumors.In the presence of benign or malignant intracranial tumors there was a slight and not significant decrease of cAMP as well as cGMP levels in the CSF, as compared to control patients. While there was no significant correlation between the levels of the two CN in controls, there was a positive correlation in tumor patients. Total protein content and cAMP were negatively correlated in malignant intracranial tumors. Possible influences of tumor growth and intracranial pressure increases on CN levels are discussed. In spinal tumor patients normal CN levels were observed. However, in a patient with meningeal sarcoma an extremely marked elevation of cAMP occurred in parallel with the extension of the tumor to the spinal meningeal space, suggesting massive secretion of cAMP from the

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03075.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The clinical characteristics of facial pain in patients with trigeminal neuralgia (TN) and associated multiple sclerosis (MS) were studied. Among 900 patients with TN 22 (2.4%) had associated MS. Sixteen patients had typical TN, while six had atypical TN. Facial pain commenced at a younger age (P<0.05) and a significantly higher proportion had bilateral facial pain (P<0.01) in the group with MS compared to TN patients without MS. In three patients TN was the first manifestation of MS, in the remainder facial pain occurred on an average of 12 years after onset of MS. Seventeen patients had associated signs of brain‐stem involvement. The facial pain was, however, indistinguishable from the pain in patients without brain‐stem deficits. While sclerotic plaques in the central nervous system probably are of etiological significance for development of TN neither clinical nor neuropathological findings suggest that this is due to affection of trigeminal nuclei complex in the brain

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03076.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Fifty alcoholics with a mean age of 45 years were examined with the intra‐arterial133Xenon method for measurement of regional cerebral blood flow and with EEG. The results were related to liver function tests. Reduced white matter blood flow correlated strongly with abnormal liver function tests. The highest correlation was with S‐ASAT. Only weak correlations were found between gray matter flow, EEG and the liver function tests. It is suggested that the relationship between white matter flow reduction and liver function may be caused by the intensity of drinking prior to admission and possibly mediated by some still unknown hepatic mechanism or a direct effect of alco

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03077.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Six ALS‐patients were given long‐term penicillamine treatment. A rapid, long‐lasting increase in urinary lead was provoked, whereas whole blood and plasma lead were unchanged. In four patients, the progress did not change markedly, one patient deteriorated rapidly and in one patient the progression slowed down after one and a half years of trea

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03078.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In a consecutive series of 35 patients with transient ischemic attacks (TIAs) 26 patients (74%) had pathological platelet aggregation 4 weeks after the latest TIA. Pathological platelet aggregation was the most frequent factor leading to a prophylactic treatment of the TIAs. Among 12 patients with reversible ischemic neurological deficit (RIND) only one had pathological platelet aggregation, and among 54 patients with completed stroke 37% had pathological platelet aggregation 4 weeks after the cerebral infarction.It is possible by the antiaggregating agents acetylsalicylic acid and dipyridamole to normalizein vitropathological platelet aggregation. The frequency of side effects was low. During this treatment further TIAs were stopped in 17/19 patients, and remission were seen in 14/14 stroke patients. Compared with the remissions during treatment with anticoagulants there was a tendency of more favouarble outcome in the group of stroke patients when treated with antiaggregating agents.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03079.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In order to evaluate the occurrence and clinical value of ocular lateropulsion in Wallenberg's syndrome, a prospective study was carried out. Lateropulsion of the horizontal and vertical refixation saccades was a rather regular finding, especially in complete Wallenberg's syndrome. Lateral ocular deviation after elimination of fixation was present in nearly all cases. The tonic lateral vector was always directed to the involved side. It is concluded that ocular lateropulsion is an easily elicited sign with a lateralizing value in lateral bulbar infarction. Further systematic search of ocular lateropulsion in other posterior fossa disorders is needed to determine its topographical significance.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03080.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03081.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Peptides of the pars intermedia. Ciba Foundation Symposium 81. Pitman Medical PressNeuroendocrine regulation and altered behaviour. Ed. byP. D. Hrdina&R. L Singhal.The spinal cord and its reaction to traumatic injury, Vol. 18. Modern Pharmacology‐Toxicology Series. Ed. byWilliam F. Windle.Current development in psychopharmacology. Vol. 6. Ed. by W. B. Essman&L. Vlazelli.Peripheral neuropathies. Report of a WHO Study Group. WHO, GenevaValproate in the treatment of seizures. Ed. byM. Dam, L. Gram, B. Pedersen&H. Ør

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03082.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY