摘要:

It has been suggested that blood viscosity is involved in the control of cerebral blood flow (CBF) (Thomas et al.1977a, b,Humphrey et al.1979). CBF, using the intravenous Xenon133technique, blood viscosity and haematocrit were measured in 21 patients with elevated viscosity due to paraproteinaemia and found to be the same as in normal subjects. However, the paraproteinaemic patients were anaemic with a mean haematocrit of 0.342. This degree of anaemia would normally be associated with a high CBF.The paraproteinaemic patients were then compared with a group of 10 anaemic patients with matched haematocrits but without paraprotein bands. The whole blood and plasma viscosities were significantly higher in the paraproteinaemic patients and the CBF was significantly lower. The haematocrit, and therefore oxygen carriage, was similar in the two groups. It is likely that in the anaemia of paraproteinaemia the expected increase in CBF did not occur because of the limiting factor of increased viscosity. This suggests that in this instance viscosity rather than oxygen carriage is a major determinant in the control of CBF. This is further emphasized by the better correlation between CBF and blood viscosity than between CBF and haematocrit. It seems likely that viscosity and oxygen carriage are independent variables in the control of CBF.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01484.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The cerebral blood flow is low in primary polycythaemia, and it has been suggested that this is due to the increase in viscosity which accompanies the elevated haematocrit. In the present study cerebral blood flow has been measured by a non‐invasive133Xenon technique in six subjects with an elevated haematocrit secondary to a haemoglobin variant with increased oxygen affinity. Flow was significantly higher than normal and 81 % higher than in 11 subjects of comparable age, matched for haematocrit and viscosity, but without the haemoglobin variant. In patients with this unusual type of polycythaemia, cerebral blood flow is high despite the elevated blood viscosity and the implications of these results are discusse

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01485.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A 57‐year‐old man with neuromyotonia and normocalcemic tetany as probable paraneoplastic symptoms of small‐cell lung cancer was examined neurophysiologically. In EMG, spontaneous action potential generation was demonstrated in peripheral motor axons. There were also time‐locked high‐frequency discharges after some voluntarily activated motor unit potentials. After electrical stimulation of motor axons, the M‐re‐sponse as well as spinal F‐response or H‐reflex was often followed by a sequence of oscillating potentials which could last several hundred msec. There was no evident peripheral polyneuropathy. Tetany subsided when carbamazepine therapy was started. The only striking abnormality in extensive laboratory studies was an increase in the plasma no

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01486.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A study of 95 patients with gliomas has been made. The 50% survival was 15 months after the first symptom. At the time of presentation all patients had an abnormal brain scan and E.E.G. except some of those who presented with epilepsy. The patients with epilepsy had a significantly better prognosis than those without and this was not due to their having less malignant tumours according to histological appearance. Other factors which were associated with significantly longer survival were a younger age at presentation, partial removal of the tumour rather than biopsy or no operation, lower histological grades of tumour and treatment with radiotherapy or chemotherapy.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01487.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Following cerebral angiography, the level of β thromboglobulin rose in five of seven patients (P=<0.05). This would indicate that there had been generalised platelet activation. In view of the morbidity of cerebral angiography it is proposed that a trial of prophylactic anti‐thrombotic therapy be institut

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01488.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A highly restricted epidemic of canine distemper occurred in southwest Iceland in 1966–67. We have determined the extent of dog contact and exposure to dogs during the distemper epidemic in Icelandic MS patients with onset since 1966. Further, age of onset, and annual incidence of MS from 1966 through 1978 have been determined. Thirty‐five of 36 MS patients had close dog contact prior to onset of their illness, and 34 were in the area of the distemper epidemic during 1966–67. A significant decrease in age of onset of MS (31.6 to 26.5) from 1956–1965 to 1967–1978 was noted, consistent with exposure of a susceptible cohort to a point infection with a variable incubation period. A review of incidence of MS in the 10‐year periods after distemper epidemics in Iceland in 1921–1922, and 1941–1942 reveal significantly more MS than in comparable time periods before these epidemics. These collective findings are consistent with, but do not prove, a relationship between dogs, d

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01489.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Convergence spasm has frequently been reported as a hysterical manifestation. A case presenting with this sign and diphenylhydantoin intoxication is described. Other previously reported organic associations are discussed. Convergence spasm may be seen in association with significant organic disease of the nervous system affecting the cerebral hemispheres, the brainstem, or both.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01490.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The concentrations of IgA, IgG and IgM were determined in sera of 16 patients, all of whom had partial epilepsy and had received CBZ as the only drug since the beginning of therapy. Fifty‐three healthy subjects served as controls. Serum concentrations of IgA and IgG were significantly higher in patients than in controls (IgA:P= 0.05; IgG:P= 0.01). The concentration of IgM was not significantly different from that of the controls (P= 0.1). The IgG serum levels in the controls were lower with increasing age. Furthermore, IgG serum levels were higher with increasing CBZ concentration

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01491.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

BOOKS reviews in this articles:Werry, J. S.(ed.): Pediatric psychopharmacology.M. Spinner:Injuries to the major branches of peripheral nerves of the forearm.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1980.tb01492.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY