摘要:

Paired serum and cerebrospinal fluid (CSF) specimens from 30 multiple sclerosis (MS) patients and 30 patients with other neurological diseases (ONDs) were analyzed for the presence of immune complexes (ICs). With each of the 4 tests used, ICs were found more frequently in sera from both MS and OND patients than in sera from healthy blood donors. IC‐positivity for MS and OND patient CSF varied from 10‐33 % and from 10‐17 % in different tests. The number of IC‐positive sera or CSF in MS patients did not differ significantly from those in OND patients. For both MS and OND patients, the positivity pattern for serum and CSF specimens in each IC test was essentially unique. Furthermore, because several CSF IC‐positive and serum IC‐negative paired specimens were found, intrathecal IC formation may be independent of IC formation in peripheral blood. The presence of ICs in serum or CSF did not correlate with the clinical status of or laboratory data on the MS patients, nor was a correlation found with the diagnosis of the OND patients. In total, these results suggest that the presence or absence of ICs in MS or OND patients may simply reflect changes in the immunological regulation of individu

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03124.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Analysis of monoamine concentrations in brain tissue was carried out on the two types of Creutzfeldt‐Jakob disease (CJD). The results showed decreased levels of catecholamines compared to control cases in a number of areas, and the reductions were most pronounced for dopamine. In general, the case classified as the amyotrophic form of CJD showed a greater degree of a monoamine loss than the case with spongiform encephalopathy, which is the typical transmissible form of CJD. These findings support the scarce available data indicating disturbances in the catecholaminergic systems in these types of brain diseases, and may have therapeutic implication

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03125.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Liquor:serum quotients of IgG and albumin in patients with meningism, meningitis and multiple sclerosis have been studied. Abnormal quotients indicative of disturbed blood‐brain barrier function and/or intrathecal IgG synthesis were found in various proportions of all 3 groups of patients. In some patients with aseptic meningitis and meningism, the abnormal quotients were comparable with those found in patients with multiple sclerosis. The reason for this is unknown. An unspecific reaction to febrile illness may be involved. As a consequence, the findings of abnormal liquor:serum quotients of IgG and albumin should be evaluated with great caution in patients with recent or present febrile illnes

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03126.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Cerebral blood flow (CBF) was studied in 11 controls and 9 house painters occupationally exposed to organic solvents for a mean of 22 years. They had mild to moderate intellectual impairment, and no or only minor cerebral atrophy was seen in a CT‐scan of the brain. The133Xe inhalation technique was used and the flow was calculated from the inital slope of the133Xe wash out curve (ISI). ISI averaged 36.8 ml/100 g/min in the painters and 45.4 ml/100 g/min in the controls, representing a significant difference (P<0.05). The reduced CBF in these painters with slight to moderate intellectual impairment might be due to limited neuronal loss or to permanently decreased metabolism of the neurone

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03127.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The visual evoked potentials (VEPs) and neuro‐ophthalmological examinations of 134 patients were compared. The VEPs were abnormal in 95 % of the eyes with optic neuritis. Defective color vision was found in 99 %, visual field defects in 88 %, decreased vision in 66 % and an afferent pupillary defect in 55 %. 29 patients with optic neuritis were followed up with repeated tests. VEPs and color vision recovered more slowly than visual acuity and visual field.Abnormal VEPs were observed in 68 % of 50 MS patients. An analysis of symptomatic and asymptomatic eyes showed that testing of color vision, visual field and red‐free ophthalmoscopy were equally as useful diagnostic tools as VEPs. 4 (8 %) of the MS patients had abnormal VEPs despite a normal neuro‐ophthalmological examination; 94 % of MS patients with symptoms and 47 % of MS patients without visual symptoms had abnormal VEPs.VEPs were pathological in 59 % of 24 patients with traumatic or compressive optic nerve diseases or optic atrophies of unknown etiology. The neuro‐ophthalmological examination was more sensitive than VEPs in the diagnosis of these disorders. A neuro‐ophthalmological examination is in most cases sufficient to diagnose optic nerve lesions. VEPs are of diagnostic aid especially in mild optic nerv

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03128.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A two‐phase epidemiological study of essential tremor was carried out by investigating a rural population aged over 40 years in 2 municipalities in southwestern Finland. In the first phase, the subjects answered a questionnaire as to whether they had experienced tremor during the month preceding the inquiry. In the second phase, the persons who had tremor often or fairly often, were examined clinically. The total prevalence of essential tremor, calculated on the basis of clinically established cases, was 55.5‰ of the population aged over 40 years. The disease became more prevalent with advancing age and was, with the exception of the oldest age‐group, more common in men than in

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03129.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

From the city center of Copenhagen, almost 20,000 people, 20 years of age and older, were randomly selected for examination after age and sex stratification. The participation rate was 72%. 231 persons responded affirmatively to a questionnaire concerning cerebrovascular disease. After neurological examination the diagnosis was confirmed in 115 cases. Adjusted on the basis of the age distribution of the Danish population (1976) the prevalence rate was calculated to be 651/100,000 for men and 385/100,000 for women.The frequency of myocardial infarction and hypertension was significantly higher in the stroke patients than in the study population. The risk factors: cigarette smoking, serum‐cholesterol, and high‐density‐lipoprotein concentration, showed no significant differences between the patients and the study population. 44% of the patients had had their stroke more than 5 years before the prevalence date. In 41% of the patients, residual neurological signs could not be demonstrated, while 59% of the patients had neurological deficits of varying severity. 30% of the surviving patients were in gainful work or managed domestic activities as they had done before the stroke. Nearly 1/2 of the severely disabled patients were independent in self care. The age group above 80 years was underrepresented in this

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03130.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In 44 consecutive patients with sellar volume larger than 1100 mm3, computer tomography showed that 20 had an empty or partly empty sella. None had radiological evidence of a suprasellar tumor. 10 of the 20 patients had experienced episodes with acute neurological symptoms presumably reflecting a pituitary apoplexy. It is suggested that an unknown proportion of intrasellar adenomas may disappear as a result of an infarction, which may comprise the entire adenoma or part of it ‐ leaving an empty or partly empty sella as diagnosed by computer tomography. Air encephalography will demonstrate the empty sella only if the diaphragmatic aperture is large enough to allow cisternal herniation. The infarction may present clinically with no, slight or severe acute neurological symptoms. Late consequences of a pituitary adenoma infarction may be rhinorrhea or hydrocephalu

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03131.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A method for measurement of postural stability has been developed indicating the transverse and saggital sway in units of length. The centre of pressure of the feet on a force‐plate is computed.This method has proved to be suitable for clinical us

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03132.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Postural stability was measured in 100 healthy people by a quantitative, computer calculated Romberg's test. The persons were aged 20‐69 years, and a table of normal ranges is provided. Older men are found to have higher sway figures than young men, while this was not significant in the group of women.In a second part of the study the reproducibility of the method was studied in 10 healthy people. Sway was measured twice a day during 5 consecutive days of work. No significant alterations in the sway measurements were found. The individual variation coefficients ranged from 11‐29% (mean value: 18%).By the present study it is concluded that the quantitative Romberg's test is a reasonable way of measuring postural stabil

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1982.tb03133.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY