ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00528.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00529.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00530.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

We compared stable xenon enhanced X‐ray computed tomography (Xe‐CT) with Technetium‐99m ethylsteinate dimer single‐photon emission computed tomography (ECD‐SPECT) in 12 patients. We evaluated the cerebral blood flow (CBF) values in the territory of the anterior, middle and posterior cerebral artery, and in the thalamus. The CBF values were higher in ECD‐SPECT than in Xe‐CT except for the values of the thalamus. The posterior cerebral artery territory showed a lower correlation and the thalamus had no correlation between two methods. We discussed causes of thes

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00531.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

The presence of epileptiform activity (EA) in the EEG of patients' relatives points to the significance of genetics in the etiology of epilepsies. Waking and sleep EEGs were recorded in 83 siblings of 54 patients suffering from symptomatic generalized tonic‐clonic seizures. EA was recorded in at least one sibling of 27 (50%) of the 54 patients. When the 83 siblings are taken as a basis, EA was found in 34 (41%) of them. Generalized spike‐wave discharges were seen in 32 cases; 2 siblings showed benign sharp wave foci in the right parietal area. EA was seen only in sleep in 44.1 %. The highest rates of EA were seen in the age range up to 15 years. EA was found in 15 of 50 male siblings (30%), but in 18 of 33 female siblings (54.5%). Therefore genetics also play an import role in the etiology of symptomatic generalized tonic‐clonic sei

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00162.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00532.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

The regional cerebral blood flow (rBCF) values measured by stable xenon‐enhanced computed tomography (Xe XT) and by radioactive xenon‐133 single photon emission computed tomography (Xe SPECT) were compared in 16 patients with cerebral infarct. On the non‐lesion side Xe SPECT recorded 10.7% higher rCBF values than Xe CT in the anterior cerebral artery territory while Xe CT recorded 9.6% higher values than Xe SPECT in the middle cerebral artery territory. These differences were not statistically significant. Although the rCBF values were almost the same no correlation was found between the two methods in the posterior cerebral artery territory and the basal ganglia. Only hemispheric CBF on the non‐lesion side showed the same value and a good correlation between the Xe CT and the Xe SPECT. There was a good correlation in the hemispheric CBF values on the lesion side, too. The difference of rCBF between the non‐lesion side and the lesion side was expressed smaller in the Xe SPECT than in the Xe CT. This is in agreement with the previous reports that Xe SPECT overestimates the flow in the low flow areas. The higher rCBF values in the anterior cerebral artery territory measured by the Xe SPECT was ascribed to the artifact from the radioactivities in the inhalation mask and the air passages as reported previously. In conclusion, there is no good correlation between the rCBF values measured by the Xe CT and by the Xe SPECT. Only hemispheric CBF shows a good correlation between the tw

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00533.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

In this Danish‐Norwegian randomized double‐blind parallel‐group multicentre study, we compared the therapeutic response of slow‐release Madopar HBS® to standard Madopar® in 134 de novo patients with idiopathic Parkinson's disease during a 5‐year period. The drugs were dosed according to the individual need of the patients. The Webster, NUDS, UPDRS and Hoehn&Yahr scales were used for evaluation of symptoms. Addition of a morning dose of standard Madopar 62.5 mg was allowed after 6 months. Bromocriptine could be administered but not Selegiline. Sixty‐five patients got Madopar HBS and 69 standard Madopar. Surprisingly, no differences were found as to the mean daily levodopa dose, the mean number of daily doses or the use of and doses of bromocriptine. Unexpectedly, we found a trend towards a more frequent use of a morning dose of standard Madopar in the group treated with the standard formulation. No differences were observed in the occurrence of motor fluctuations or dyskinesia, the incidence of which was relatively low. Sustained‐release Madopar (HBS) thus proved to be as effective as standard Madopar in the long‐term treatment of de novo parkinsonian patients, but the drug showed no advantage in postponing or reducing the long‐term levodopa

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00163.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00534.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

The means of the cerebral blood flow (CBF) values obtained by the stable xenon enhanced CT (Xe/CT) method using two different CT scanners were compared with the global CBF value obtained by the Kety‐Schmidt (N2O) method as a reference. Xe/CT CBF values were obtained using a GE CT9200 (31 patients, 2 flow maps, 120 kV, absorption constant of 0.040) as well as a GE ProSeed Accell (38 patients, 4 flow maps, 80 kV, absorption constant of 0.028). The protocol of inhalation in the Xe/XT method consisted of 4 min wash‐in and 4‐min wash‐out of 35% stable xenon. In the Kety‐Schmidt method, 15% N2O gas was inhaled for 10 min. The N2O content of blood samples was measured using a van Slyke‐Neill blood gas analyzer. We corrected all obtained CBF values for a PaCO2of 34 mmHg (CBF34).The global CBF34values obtained by the Kety‐Schmidt method were linearly correlated with the CBF34values obtained using the CT9200 and with those obtained using the ProSeed Accell, and the regression line equations were, respectively, Y=0.64X+13.7 (X: CT9200, Y: Kety‐Schmidt, r=0.666, p<0.01) and Y=0.99X+11.2 (X: ProSeed Accell, Y: Kety‐Schmidt, r= 0.756, p<0.01). Since the CBF values obtained by the Xe/CT method using different CT scanners are not always the same as the global CBF values obtained by the Kety‐Schmidt method, CBF values obtained by the Xe/CT method should be corrected referring to the regression line obtained by applying both metho

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1996.tb00535.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY