摘要:

ABSTRACTCerebrospinal fluid (CSF) and serum samples from 40 multiple sclerosis (MS) patients and 48 control patients were examined by a microcomplement fixation test for the presence of antibodies against saline extracts of human brain. When tested with an IgG content standardized to 100 mg per 100 ml, 13 of the MS CSF and one of the corresponding MS sera were positive, whereas none of the control specimens were positive. the antibody was shown to be highly organ specific when tested against extracts of myocard, spleen, kidney and peripheral nerve. Chromatographic experiments showed the antibody to belong to the IgG class. It was concluded that the antibody was probably synthesized intrathecally in 12 and extrathecally in one MS patient.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07616.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTCerebral lactate, pyruvate and adenosine triphosphate (ATP), and arterial acid‐base balance were measured in normotensive rats (NTR) and spontaneously hypertensive rats (SHR) at various time intervals following bilateral carotid occlusion. In SHR, a great and progressive increase in cerebral lactate and lactate/pyruvate ratio (L/P ratio) during the first 5–6 hours after occlusion was followed by a gradual decrease as the time interval increased. Cerebral ATP in SHR decreased as cerebral lactate increased, and an inverse relationship was observed between lactate and ATP. On the other hand, in NTR, there were minimal changes in cerebral lactate and L/P ratio following carotid occlusion. These results suggest that bilateral carotid occlusion might cause severe ischemic damages of the brain in SHR, but not in NTR. the hemodynamic factor as a cause of cerebral ischemia in hypertensives is discus

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07617.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTA social investigation was performed of 74 patients with temporal lobe epilepsy resistant to medication, who underwent unilateral temporal lobectomy 1960–1969. the patients were compared to their siblings and to the general population in Denmark. Comparatively many patients were born out of wedlock. the level of schooling achieved was lower than expected, and this was most pronounced in patients with an early onset of epilepsy. the number of patients having received further education was also smaller than calculated. At the time of the operation all patients were socially incapacitated by their epilepsy; this was most pronounced in males, of whom 30 per cent were institutionalized and 32 per cent were receiving disablement pension; at follow‐up the figures were 6 per cent and 52 per cent, respectively. Working capacity was markedly improved postoperatively, and at follow‐up 39 per cent were in full‐time employment. Relief from seizures (or almost complete relief), normal intelligence, normal psychiatric status, and operation before the age of 18 years were factors which favourably influenced the postoperative working capacity. the majority of the patients were unmarried or divorced, and few of the group had children. Their housing conditions were inferior to those of their siblings and of the general population. Parental social class distribution showed an excess in the highest and lowest social classes compared to the Danish population. the patients were subjected to downward social mobility, presumably caused by their illness, as their siblings displayed an upward mobility, which was most marked in the

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07618.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe ATPase reaction and its pH lability demonstrate three fiber types in the adult mouse gastrocnemius; Type I (light staining with alkaline preincubation and dark with acid preincubation), Type IIA (dark after alkaline preincubation), type IIB (dark after alkaline and acid preincubation). the SDH and NADH‐tetrazolium reductase reactions also demonstrate three types of fibers; those low (A), intermediate (B) or high (C) in oxidative enzyme activity. However, the use of both procedures in serial sections demonstrates that four different combinations occur; the IIB fibers are high in SDH activity, the I fibers are intermediate in SDH enzyme activity, while the IIA fibers are either low or intermediate in SDH activity. These fiber types are present within the gastrocnemius muscle in a distinct pattern of zones. the predominant fiber type, located in the superficial half of the muscle, is the IIA (A) fiber which is high in ATPase and low in SDH activity. This is consistent with the fact that the gastrocnemius is generally considered a white, fast muscle. the IIB and I fibers are fewer in number and are located deeper in the muscl

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07619.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTEcho‐encephalographic examinations were performed in 144 patients after subarachnoid hemorrhage. Ninety‐three of the patients received antifibrinolytic treatment (AMCA). the width of the third ventricle could be measured in all the patients, and lateral ventricle measurements were obtained in 94 patients. Third ventricular dilatation developed in 78 patients (54 per cent), and lateral ventricle enlargement was seen in 55 patients (58 per cent of those examined). the incidence of third ventricle dilatation was higher in the AMCA‐treated group (62.5 per cent) than in the non‐treated group (39.2 per cent), and this difference was statistically significant (P<0.05). the hydrocephalus in most cases developed 2–3 weeks after the bleeding, and reached its peak within the first 2–3 months, with subsequent complete or partial normalization of the ventricular size. At later follow‐up examinations 1–4 years after the bleeding, only nine patients had persisting dilatation of moderate or pronounced degree. There was no indication that the dilatation was more severe or protracted in the AMCA‐treated group than in the non‐treated group. In 11 patients the hydrocephalus required a shunt‐operation, but the frequency of shunt‐operations was not significantly different in the two groups. It is concluded that although AMCA‐treated patients in comparison with non‐treated patients are exposed to a somewhat higher risk of complicating hydrocephalus after subarachnoid hemorrhage, this risk cannot at present be considered as any serious contraindicatio

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07620.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTClinical examinations, questionnaires, and 24‐ or 36‐hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short‐ and long‐term effects of clomipramine HCL. Cataplexy was improved by the medication, but tolerance was observed after 4 1/2 months of treatment. Clomipramine HCL induced significant changes in the sleep EEG, chin EMG, and EOG. In two patients, clomipramine HCL caused a nocturnal myoclonia that produced insomnia. Sexual side effects were seen with clomipramine HCL, particularly in males. A combination of clomipramine HCL and L‐Dopa apparently prevented this difficulty in one patient. A rebound of cataplexy was seen during the 15 days following withdrawal of the drug. Methysergide maleate was found to be ineffective on cataplexy in four

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07621.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb07622.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY