ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

The recently discovered endogenous δ-selective opioid peptide, endomorphin-2, and the endogenous δ-selective opioid peptide, Leu-enkephalin, were tested for their ability to affect spatial learning in the Morris water task. It was found that microinjection of 10 nmol endomorphin-2 into the CA3 region of the rat hippocampus significantly impaired spatial learning. However, the two lower doses tested, 3.3 and 1 nmol, had no effect in this test. Leu-enkephalin did not have any effect on spatial learning at the two doses tested (10 and 3.3 nmol). Neither peptide had any effect on motor performance as measured by swim speed. The results indicate that δ-receptors in the CA3 region of the rat hippocampus are more relevant than δ-receptors for spatial learning.

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

LATI (the 4F2-light chain I) is a component of the CD98 surface antigen which participates in multiple functions including amino acid transport, cell survival, cell fusion and integrin activation. We examined the distribution of LATI in the mouse brain using immunohistochemistry. LATI was expressed on the microvessels, the subfornical organ, the subcommissural organ, ventromedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus, ependymal layer of the lateral ventricles, and the olfactory bulb. LATI-positive cells incorporated bromodeoxyuridine in the latter three regions where neurogenesis occurs in adult mouse brain, indicating that LATI is involved in neuronal cell proliferation, as well as in amino acid transport in these regions.

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Paradoxical sleep (PS), in which periods with (phasic) and without (tonic) rapid eye movements are intermingled, is hypothesized to be related to cognitive processing and dreaming. Based on polysomnographic data from 12 healthy subjects, this study focuses on the spectral differentiation between phasic and tonic periods. Phasic PS periods exhibited decreased theta and alpha power in the posterior brain areas suggesting the interference of visual processing related to dream imagery. Phasic PS periods were also characterized by a shift from beta to gamma activity in frontal, central and occipital areas reflecting specific phasic related activation. Together, these findings bring new evidence for the existence of visual imagery and cognitive processing during phasic PS.

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Neuregulins (NRG), the only trophic factors known to support Schwann cell survival, have a potential for use in treatment of patients with chronic neuropathies. Expression of one NRG isoform, NRG-β1, was increased in axons in the early phase of axonal degeneration in nerve biopsy specimens from patients with neuropathy. Regenerating nerve fibers contained abundant NRG-β1 in axons, but nerves from patients with chronic axonal neuropathy showed less. NRG-β1 may act as an axonally derived signal having a trophic effect on denervated Schwann cells, facilitating their supportive role in axonal regeneration.

ISSN:0959-4965    

出版商:OVID    

年代:2000

数据来源: OVID