ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

We investigated the role of the celiac branch of the vagus nerve in suppression of food intake produced by jejunal fatty acids infusions. Following selective celiac vagotomy or sham surgery, adult, male Sprague–Dawley rats received 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced significant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of results suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

We visualized the brain activity for retrieval imagery of a sound using dual 37-channel magnetometers in seven right-handed healthy subjects. A soundless video image of a hammer striking an anvil was presented on a screen. Significantly larger evoked magnetic fields were recorded, dominantly in the right hemisphere, in six subjects when they imagined the sound than when they did not. The initial peak of the response was 151.0 ± 26.5 ms (mean ± s.d.) after the blow. Equivalent current dipoles (ECDs) for the responses recorded from the right hemisphere were located around the inferior frontal sulcus in three subjects and in the insular region in three subjects, but reliable ECDs were not estimated from the left hemisphere. The results suggested that the initial activity for sound retrieval imagery appeared around the inferior frontal and insular areas, dominantly in the right hemisphere.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Mu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence. The present study examined the involvement of a polymorphism in A118G in exon 1 and C1031G in intron 2 of the MOR gene in 200 Chinese heroin-dependent and 97 control subjects. Results showed a significant association for both A118G and C1031G polymorphisms and opioid dependence. The G allele is more common in the heroin-dependent group (39.5% and 30.8% for A118G and C1031G polymorphisms, respectively) when compared to the controls (29.4% and 21.1% for A118G and C1031G polymorphisms, respectively). This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior. Aggression in humans and animals is often associated with low serotonin levels. This study examined the anti-aggressive properties of phenytoin in rodent isolation-induced aggression using a resident–intruder test to quantify aggression. Chronic treatment withp-chlorophenylalanine (PCPA), a competitive inhibitor of serotonin synthesis, significantly enhanced resident attack behavior compared to saline-treated control rats. Phenytoin dose-dependently re- duced aggressive behavior specifically in PCPA-treated rats, but had no anti-aggressive properties in saline-treated rats. These data suggest that aggressive behavior in this model may be related to neuronal hyperexcitability that is sensitive to the anticonvulsant effects of phenytoin. Further, these data suggest isolation-induced aggression in PCPA-treated rats may be a useful model to investigate aggression associated with low serotonin in the brain.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

It remains unclear how high frequency stimulation of the subthalamic nucleus (STN) improves parkinsonism. We hypothesized that stimulation may affect the organization of the cortical drive to voluntarily activated muscle. Normally this is characterized by oscillations at 15–30 Hz, manifest in coherence between muscles in the same frequency band. We therefore investigated the effects of STN stimulation on electromyographic (EMG) activity in co-contracting distal arm muscles in nine subjects with Parkinson's disease off drugs. Without stimulation, coherence between EMG signals was diminished at 15–30 Hz compared with nine controls. STN stimulation increased coherence in the 15–30 Hz band, so that it approached that in healthy subjects. The results suggest that STN stimulation facilitates the normal cortical drive to muscles.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID