ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Heterozygous mice mutant for the NMDA-type glutamate receptor (GluR) &epsis;2 subunit with a highly homogeneous genetic background showed exaggerated responses to various acute noxious stimuli in the footshock, tail-flick, hot-plate and tail-pinch tests. Because the noxious stimuli in these behavioral tests were electrical, thermal and mechanical, the reduction of GluR&epsis;2 proteins exerted stimulatory effects on acute nocicep- tive responses across modalities. Previous studies showed that GluR&epsis;1 and GluR&epsis;4 subunit mutant mice exhibited no alteration in the responses to acute noxious stimuli. Thus, among NMDA receptor subunits, the GluR&epsis;2 subunit specifically plays an important role in the regulation of the acute nociceptive responses.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The present study examines whether or not prolactin-releasing peptide (PrRP) infused intracerebroventricularly (i.c.v.) affects sleep and the release of prolactin (PRL) and growth hormone (GH) in rats. At a dose of 0.1 nmol, PrRP promoted rapid-eye-movement (REM) sleep, whereas 1.0 nmol increased both non-REM and REM sleep and 10.0 nmol enhanced only non-REM sleep. During the i.c.v. infusion of PrRP with 0.1 nmol, levels of plasma PRL were elevated, but GH levels were significantly decreased. Since it is reported that PrRP fails to induce PRL release from the male pituitary, the stimulatory effects of PrRP on PRL release observed here seem to be indirect. However, PRL stimulated by i.c.v.-infused PrRP could take part in the REM sleep-promoting activity of PrRP.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The microtubule-associated tau proteins are abnormally aggregated in many tauopathies. Phosphorylation modulates the functions of tau. The serine 199 residue of tau is abnormally phosphorylated at early and late stages of Alzheimer's disease. The presence of the phosphorylated Ser199 was investigated in autopsy-derived and biopsy-derived brain tissue samples from non-demented individuals. A paradoxical expression was found in the hippocampus of the youngest ones, in granule cells of the dentate gyrus and in pyramidal cells of the Ammon's horn, which are particularly prone to neurodegeneration in several tauopathies. The rate of positive cells decreased with age. These data emphasize the importance of the phosphorylation of the Ser199 residue of tau in ageing and susceptibility to neurodegeneration.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

We have demonstrated previously that exogenously expressed Brn-3a is capable of protecting neurons of the peripheral nervous system against apoptosis. In these previous studies Brn-3a showed a degree of neuronal sub-type specificity, in that while it could promote survival in NGF-dependent sensory neurons, no effect was observed in NGF-dependent neurons of the sympathetic nervous system. In this report, we show that Brn-3a delivered using a herpes simplex virus is capable of protecting cultures of rat cerebrocortical neurons of the central nervous system against two types of cell death stimuli, including glutamate neurotoxicity. Hence the protective effect of Brn-3a is not confined to neurons of the peripheral nervous system but can also occur in neurons of the CNS.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

A spoken word with more than one syllable contains a specific stress pattern found to be processed during spoken word recognition. The present study investigated the word's pitch contour as a single auditory parameter that marks stress. Event-related brain potentials (ERPs) were recorded while subjects made decisions to artificially pitch manipulated words. ERPs revealed that pitch contours are discriminated already within the first syllable of a word. Furthermore, behavioral responses for words with incorrect pitch contours were longer than for words with correct pitch contours. The results suggest that the pitch contour is an auditory feature of the spoken word that a listener automatically processes during spoken word recognition.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of CPON-positive cells). The compression-induced increase in CPON was less than that observed in separate rats subjected to sciatic nerve transection. The results show that compression induces regenerative changes in peripheral neurons and that such an injury of the nerve trunk is not limited to the site of the compression but results in the activation of the entire neuron.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Much research is now focused on a potential vaccine for Alzheimer's disease (AD). Current studies involve administering the amyloid β peptide (Aβ) in Freund's complete adjuvant, which cannot be used in humans. Our studies show that the immune complex of Aβ is taken up by a receptor-mediated process at the blood–brain barrier (BBB). The success of immunization for AD, therefore, may be critically dependent on circulating Aβ levels which are lower in AD patients compared to AD transgenic mice. Moreover, we have found that modifying the antibody with polyamine increases its BBB permeability and may provide a better approach to passive immunization for Alzheimer's disease.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Single unit activity was studied in brain slices of normal and overweight adolescent rats, the latter grown up until weaning in small litters of three pups per mother (SL). Significantly fewer neurons of the ventromedial hypothalamic nucleus (VMN) were activated by insulin in overweight SL rats than in normal (NL) rats (χ2p< 0.01). Although there is no significant difference between NL and SL rats in the number of VMN neurons responsive to insulin, the neurons differ in the type of reaction. In overweight SL rats neurons were mainly inhibited by insulin (Wilcoxon testp< 0.0001,n= 45). This altered response to the satiety signal insulin in postnatally overnourished rats might contribute to their persisting hyperphagia and overweight.

ISSN:0959-4965    

出版商:OVID    

年代:2001

数据来源: OVID