ISSN:0905-6157    

DOI:10.1111/j.1399-3038.1991.tb00321.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0905-6157    

DOI:10.1111/j.1399-3038.1991.tb00322.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Metachromatic cells and eosinophil leukocytes were studied prospectively in 64 newborns with and without a family history of atopic disease (FH). Cell findings in nasal mucosa and peripheral blood were related to development of atopic symptoms up to 18 months of age. For this purpose, a gentle scraping method suitable for infants was developed. Nasal metachromatic cells were more prevalent in atopic than in non‐atopic infants. The cells were found in infants with respiratory allergy as well as in infants with eczema. Non‐atopic infants with metachromatic cells all had FH. The cells were detected prior to, or at the time of diagnosis. Thus, metachromatic cells are associated with atopic propensity as defined by development of atopic disease and/or a FH. Infants with respiratory allergy more frequently had acute otitis media than infants with eczema and non‐atopic infants. Presence of nasal metachromatic cells was associated with increased middle‐ear morbidity in atopic and non‐atopic infants, and high cell scores correlated with high frequency of otitis media. Infants with respiratory allergy may have otitis media as a result of the allergic condition. Blood eosinophils were studied in 154 infants and were found to decrease with age. Blood eosinophilia at 3 months preceded atopic development but was not associated with FH. Nasal eosinophilia was a common finding in atopic and non‐atopic infants. In conclusion, presence of nasal metachromatic cells and blood eosinophilia is associated with atopic disease, even before the appearance of clinic

ISSN:0905-6157    

DOI:10.1111/j.1399-3038.1991.tb00323.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY