摘要:

AbstractA new total synthesis of 2,2′ ‐bipyrimidine derivatives by the direct condensation of 2‐amidinopyrimidinebenzenesulfonate with dicarbonyl compounds is described. The following 2,2′‐bipyrimidines have been prepared: 5‐ethyl‐4,6‐dihydroxy‐2,2′‐bipyrimidine; 5‐ethyl‐4,6‐dichloro‐2,2 ‐bipyrimidine; 4,6‐dihydroxy‐2,2′ ‐bipyrimidine; 5

ISSN:0022-152X    

DOI:10.1002/jhet.5570100111

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe synthesis of 1,3,4,6‐letrahydro‐6‐metliy]‐2H,5H‐[1,4]diazepino[6,5‐b] indole‐2,5‐diones and 5‐phenyl‐3,6‐dihydro[1,4]diazepino[6,5‐b]indole‐2(lH)one is described. Also detailed is the, preparation of

ISSN:0022-152X    

DOI:10.1002/jhet.5570100112

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractTwo new products of hydrolysis of cyclophosphamide in water at 100°,N‐(2‐chloroethyl)‐N' ‐(3‐phosphatopropy l)ethylenediamine andN‐(2‐hydroxyethyl)‐N‐(3‐phosphatopropyl)ethylene‐diamine, have been isolated after 30 minutes, and 6 hours of reaction times, respectively. These products have been shown to be intermediates leading to the formation ofN‐(2‐hydroxyethyl)‐N'‐(3‐hydroxypropyl)ethylenediamine, the principal ultimate product of cyclophosphamide hydrolysis. The nature of these new products supports the previously postulated mechanism involving an intramolecular alkylation as the initial step in the hydrolytic process although the pathway appears to be an unlikely model for the metabolic transforma

ISSN:0022-152X    

DOI:10.1002/jhet.5570100113

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe structure of an anomalous product, isolated as a companion substance during the catalytic dehydrogenation of 1,3‐diamino‐5,6‐dihydrobenzo[ƒ] quinazoline, has been elucidated with the aid of chemical and spectral evidence, including mass spectrometric data. The mass spectrometric fragmentation pattern of the compound is in good agreement with the assigned str

ISSN:0022-152X    

DOI:10.1002/jhet.5570100114

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractIndolo[1,2‐c] quinazolines, indolo[1,2‐d] [1,4]benzodiazepines, indolo [1,2‐d] [1,4]benzodi‐azepin‐6‐ones and benzimidazo[1,2‐d] [1,4]benzodiazepin‐6‐ones were synthesized. In an acid medium, the indoloquinazolines were produced from 2‐(o‐aminophenyl)indole and acyl halides. However, in the presence of sodium acetate, the acylated amine was obtained and was cyclized to the indolobenzodiazepinones using sodium hydride. The syntheses are described in detail and characteri

ISSN:0022-152X    

DOI:10.1002/jhet.5570100115

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

Abstract2‐Aminobenzimidazole reacts with α,β‐unsaturated carboxylic acid chlorides or esters to give only pyrimido [1,2‐a] benzimidazol‐2‐(1H) ones. β‐Ethoxymethylenemalonie acid derivatives or β‐ketocarboxylic acid derivatives give only pyrimido [1,2‐a] benzimidazol‐4‐(1H)ones. Structural assignments based on nmr and chemical mani

ISSN:0022-152X    

DOI:10.1002/jhet.5570100116

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractCondensation of dimethyl 1,2‐dihydro‐2‐oxopyridine‐4,6‐dicarboxylate (IIIb) with methyl acrylate yielded 1,2,3,5‐tetrahydro‐2,7‐dimethoxycarbonyl‐1,5‐dioxoindolizine (IV), which on hydrolysis and decarboxylation gave 1,2,3,5‐tetrahydro‐1,5‐dioxoindolizine‐7‐carboxylic acid (VI). Friedländer condensation of VI with 2‐aminobenzaldehyde, followed by esterification of the resulting oxoindolizino[1,2‐b]quinoline‐7‐carboxylic acid (VIIa), yielded a potential camptothecin intermediate 9,10‐dihydro‐7‐methoxycar

ISSN:0022-152X    

DOI:10.1002/jhet.5570100117

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

ISSN:0022-152X    

DOI:10.1002/jhet.5570100118

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

ISSN:0022-152X    

DOI:10.1002/jhet.5570100119

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

ISSN:0022-152X    

DOI:10.1002/jhet.5570100120

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY