摘要:

AbstractFrom 2‐methylthioimidazoline and phenaeylbromides in DMF there were obtained the 2‐(2‐methylthio‐2‐imidazolin‐1‐yl)aeetopht'nones3a‐3f. From these the substituted 3‐phenyl‐1,4,6,7‐tetrahytlroimidazo[2,1‐c][1,2,4]triazines4a‐4nwere prepared upon reaction with hydrazine and methylhydrazine respectively. Compound 4a was degraded to the triazine 6. From the (2‐methylthio‐2‐imidazolin‐l‐yl)‐acetie acid ester 10, the imidazo[2,1‐c] [1,2,4]triazines11a‐11cwere prepared. Selective ethylation on the oxygen was achieved

ISSN:0022-152X    

DOI:10.1002/jhet.5570140111

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

Abstract4‐(4‐PhenyI‐3‐pyrazolyl)‐4H‐1,2,4‐triazoles and 4‐phenyl‐5‐(4H‐1,2,4‐triazol4‐yl)‐3‐pyrazolols were prepared by the reaction of formylhydrazine on α‐phenyl‐α‐cyanoacetaldehyd

ISSN:0022-152X    

DOI:10.1002/jhet.5570140112

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractThe synthesis of four dialkyl and three eyeloalkyl analogs of psilocin (4, R ‐ CH3), a hallucinogenic principle found in certain fungi, is described. The synthetic route involves four transformations starting with 6,7‐dihydroindol‐4(5H)one

ISSN:0022-152X    

DOI:10.1002/jhet.5570140113

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractSynthesis of substituted 3‐acyl‐4‐carbethoxypyrazoles, 5‐earbethoxy‐4(1H)pyridazinones and pyrazolo[3,4‐d]pyridazine‐4(5H)ones is described. They involve the reaction of the 2,5‐substituted‐4‐earbelhoxy‐2‐hydroxy, methoxy and acetoxy‐3(2H)furanones with hydrazine hydrate. The reaction was found to be dependent on the hydroxy, methoxy or acetoxy substituents of these furanones and proceeds with ring opening followed by cy clisation. Pyrazoles were formed with hydroxy or methoxy substituents while pyridazinones are afforded with acetoxy group. The pyrazoles so formed were readily converted to pyrazolo[3,4‐d] pyridazinones by condens

ISSN:0022-152X    

DOI:10.1002/jhet.5570140114

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

Abstracts‐Triazolo[4,3‐bJpyridazine (I) photochemically reacted with dihydropyran; 2,3‐dihydro‐p‐dioxin; 2,5‐dihydrofuran; 2,5‐dimethoxy‐2,5‐dihydrofuran; and 1,3‐dioxep‐5‐ene to give a new series of substituted pyrrolo[1,2‐b]‐.s‐triazoles (II‐IX). In most reactions, two or more products were formed. The following compounds have been prepared from I: 9‐methylene‐4a,5,6,7,8a,9‐hexahydropyrano[2,3 :4,5]pyrrolo[1,2‐b]‐s‐triazole (Ha), the corresponding 9‐cyanomethyl product (III), and 9‐methylene‐4a,7,8,8a‐tetrahydro‐6H,9H‐pyrano[3′,2′:4,5]pyrrolo[1,2‐b]‐s‐triazole (IIb) from dihydropyran; 9‐methylene‐4a,6,7,8a‐tetrahydro‐9H‐p‐dioxino[2′,3′:4,5]‐pyrrolo[1,2‐6]‐s‐triazole (IV) from 2,3‐dihydro‐p‐dioxin; 8‐methylene‐4a,5,7a,8‐tetrahydro‐7H‐furo[3′,4′:4,5]pyrrolo[1,2‐b]‐s‐triazole (V) and the corresponding 8‐cyanomethyl product (VI) from 2,5‐dihydrofuran; 8‐cyanomethyl‐5,7‐dimethoxy‐4a,5,7a,8‐tetrahydro‐7H‐furo[3′,4′:4,5]‐pyrrolo[1,2‐6]‐s‐lriazole (VII) from 2,5‐dimethoxy‐2,5‐dihydrofuran; and 10‐methylene‐4a,5,9a,10‐tetrahydro‐9H‐[1,3]dioxepino[5′,6′:4,5]pyrrolo[1,2‐b]‐s‐triazole (VIII) and the corresponding 10‐cyanomethyl product (IX) from 1,3‐dioxep‐5‐ene. The addition o

ISSN:0022-152X    

DOI:10.1002/jhet.5570140115

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractA series of novel macrocyclic multidentate crown compounds have been prepared from a series of dioxodioic acids. The dioxodioic acids were prepared by treating various oligoethylene glycols or amines with maleic, succinic, citraconic, and glutaric anhydrides. The crown compounds were then synthesized from the dioxodioic acid chlorides obtained from the diacids and various oligoethylene glycols or ethylene diamine. The following macrocyclic compounds have been prepared: 1,4,9,12‐tetraoxacyclohexadecane‐5,8,13,16‐tetrone (1); 1,4,7,10,15,18‐hexaoxacyclodocosane‐11,14,19,22‐tetrone (2); 1,4‐dioxa‐9,12‐diazacyclohexadecane‐5,8,13,16‐tetrone (3); 1,4,7‐trioxa‐12,15‐diazacyclonoadecane‐8,11,16,19‐tetrone (4); 1,4,7,10‐tetraoxa‐15,18‐diazacyclodocosane‐11,14,19,22‐tetrone (5); 4‐benzyl‐1,7,12,15‐tetraoxa‐4‐azacyclonona‐decane‐8,11,16,19‐tetrone (6); 1,4,7,12,15,18‐hexaoxacyclodocosa‐9,20‐diene‐8,11,19,22‐tetrone(7); and 9,21‐dimethyl‐1,4,7,1

ISSN:0022-152X    

DOI:10.1002/jhet.5570140116

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractThe mass spectral fragmentation of 2,2′‐thiodipyridine is reported. The base peak is due to the MI ion. The principal fragmentation routes involve loss of H, CS, CHCS and HCN from the molecular ion and CS, HCN and S from the. M‐I species. Rupture of the central bonds is also an important disintegration

ISSN:0022-152X    

DOI:10.1002/jhet.5570140117

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractThe rates of base‐catalyzed hydrogen‐deuterium exchange at C‐2 in 1‐benzothiophene, benzofuran, benzothiazole and benzoxazole were studied. For benzothiophene benzofuran the relative second‐order rale constants of hydrogen‐deuterium exchange were 4:1, while for benzothiazole and benzoxazole they were 1:20. These data can be explained by assuming that the sulphur heteroatom interacts electronically with the atom in position 3 of the five‐membered ring. While, very probably, the d‐orbital conjugation cannot depend much on the: atom in position 3, the polarization phenomena can vary more with the atom in position 3. For this reason it was thought that the electronic activity ol the sulphur heleroatom is due to polarization phenomena rather that d‐or

ISSN:0022-152X    

DOI:10.1002/jhet.5570140118

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractA new one‐step facile method for the synthesis of 1,12,3,4‐tetrahydro5H‐5‐oxo‐1,4‐benzo‐diuzepines is described. The method involves the addition of methyl anlhranilates to elhyl‐enimine followed by intramolecular cyclizalion of the resulting intermediate compounds. Another attempted method starting from β‐anilinoethylisocyanales

ISSN:0022-152X    

DOI:10.1002/jhet.5570140119

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY

摘要:

AbstractThe synthesis of several isoearboslyrils is reported, including lorrnyl derivatives at (1‐4, like nareiclasie aldehyde (I) and the homologous aldehyde (XV

ISSN:0022-152X    

DOI:10.1002/jhet.5570140120

出版商:Wiley‐Blackwell    

年代:1977

数据来源: WILEY