摘要:

Abstract4‐Chloroquinoline‐5,8‐dione (8a) and 6‐bromo‐4‐chloroquinoline‐5,8‐dione (8b) were reacted with homophthalic anhydride to give tetracyclic compounds10and11respectively. The 6,11‐dihydroxy derivative12was prepared in low yield by photochemical addition of benzocyclobutenedione to 4‐chloroquinoline‐5,8‐dione (8a) and in better yield through a Friedel‐Crafts reaction of phthalic anhydride with 4‐chloro‐5,8‐dimethoxyquinoline (7a). Whereas 4‐chloro‐6‐hydroxynaphtho[2,3‐g]quinoline‐5,12‐dione (11) was substituted by amines in the usual way to the corresponding 4‐amino‐substituted derivatives, 4‐chloro‐11‐hydroxynaph‐tho[2,3‐g]quinoline‐5,12‐dione (10) led to a mixture of 4‐amino derivatives and the unexpected 2,6‐di

ISSN:0022-152X    

DOI:10.1002/jhet.5570300111

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractMethyl 3α‐hydroxy‐5β‐cholan‐24‐oateIIIand methyl 3α,12α‐dihydroxy‐5β‐cholan‐24‐oateIVwere converted into the respective hydrazidesVandVIby reaction with hydrazine. These hydrazides were reacted with aryl aldehydeVIIto give the corresponding 24‐arylidene‐hydrazidesVIIIandIX.The reaction of Schiff basesVIIIandIXwith monochloroacetyl chloride in the presence of triethyl

ISSN:0022-152X    

DOI:10.1002/jhet.5570300112

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractA novel fused oxonorbornyl ring system synthesized by reaction of substituted aniline and methacrolein dimer in acidic media has been characterized by single crystal X‐ray diffraction. Two such structures are reported herein. These compounds represent the first reported structures of fused oxonorbornyl derivative

ISSN:0022-152X    

DOI:10.1002/jhet.5570300113

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractThe facile two step, one pot synthesis of heretofore unknown 2‐hydroxy‐4,6‐bis(trifluoromethyl)‐pyridine‐5‐carboxylates by condensation of 3‐amino‐4,4,4‐trifluoro‐2‐butenoate with 4,4,4‐trifluoroacetoacetyl chloride and subsequent intramolecular cyclization of the resultant enamineamide is described. Methodology for the introduction of electrophiles at the 3‐position and elaboration of substituents at the 2‐ and 5

ISSN:0022-152X    

DOI:10.1002/jhet.5570300114

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractTetrahydrocarbazoles have been prepared in one‐flask syntheses from indoles, ketones or aldehydes, and maleimides, with acid catalysis. The reactions involve a condensation of the indole with the ketone or aldehyde, followed by anin situtrapping of the vinylindole in a Diels‐Alder addition with a maleimide. Isomerization of the double bond into the indole nucleus gave the tetrahydrocarbazoles which were isolated (6, 9, and10). Variation of the indole, carbonyl compound, and maleimide has been explored. The predominant stereochemistry of the tetrahydro ring in the products is all‐cis, although a second stereoisomer has been isolated. Two regioisomers were generated from all unsymmetrical 2‐alkanones, except 2‐butanone, which gave the single isomer9a. Aromatization of tetrahydrocarbazoles6to carbazoles7was accomplished with 2,3‐dichloro‐5,6‐dicyano

ISSN:0022-152X    

DOI:10.1002/jhet.5570300115

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractA new class of solid‐liquid phase‐transfer catalysts (SL‐PTC) has been prepared by the reaction of octachlo‐rocyclotetraphosphazatetraene and polyethylene glycol monoalkyl ether. These polypodands are found to be powerful metal cation complexing agents and very efficient catalysts in anion promoted reactions (e.g.nucleophilic substitution and reduction rea

ISSN:0022-152X    

DOI:10.1002/jhet.5570300116

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractThe reaction of dibenzalcyclohexanone with hydroxylamine hydrochloride afforded three compounds1–3including the aziridine3showing a 3′,3a′‐transconfiguration. Now we report on the isolation of a new aziridine4, possessing a 3′,3a′‐cisconfiguration. Its structure was deduced by 2D nmr and single crystal X‐ray diff

ISSN:0022-152X    

DOI:10.1002/jhet.5570300117

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractSome 2‐substituted 5‐(1,3‐dithiolan‐2‐ylidene)‐1,3‐dioxane‐4,6‐dione derivatives3were prepared from the condensation reaction of 1,3‐dithiolan‐2‐ylidenemalonic acid (2) with carbonyl com

ISSN:0022-152X    

DOI:10.1002/jhet.5570300118

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractFour heterocyclic amines including 1,2‐diethyl‐3‐aminomethylpyrazolidine (3), 1‐(2‐aminoethyl)‐2‐methyl‐pyrazolidine (5), 1,2‐dimethyl‐4‐aminomethylpyrazolidine (7), and 1,2‐diethyl‐4‐aminopyrazolidine (9) have been synthesized. Each was acylated withp‐nitrobenzoyl chloride and afforded the correspondingp‐nitro‐benzamides10, 12, 14, and16.Catalytic reduction of these nitro intermediates gave the correspondingp‐aminobenzamides11,13,15, and17. The latter compounds are analogs of procainamide and two of them,15and17, were evaluated in the isolated cardiac Purkinje fiber preparation by measuring their effects on the

ISSN:0022-152X    

DOI:10.1002/jhet.5570300119

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY

摘要:

AbstractCatalytic reduction of 2‐nitrofurans2gives low yields of 2‐aminofurans1which are not isolated but are trapped using ethyl ethoxymethylenecyanoacetate (6) or ethoxymethylenemalononitrile (7). In these reactions 2‐aminofuran (1a) behaves like a dieneamine with substitution occurring at position 5 of the ring. When the 5‐position is substituted reaction takes place at position 3 and thermal cyclisation of the product gives furo‐[2,3‐b]pyridine derivatives16. An AM1 calculation of the properties of 2‐aminofuran (1a) is reported and the results are consistent with observ

ISSN:0022-152X    

DOI:10.1002/jhet.5570300120

出版商:Wiley‐Blackwell    

年代:1993

数据来源: WILEY