摘要:

AbstractA series of 6,7‐phenanthreno‐ and 6,7‐acenaphthenopteridines bearing different substituents at positions 2 and 4 are prepared. The structures of the compounds are confirmed by spectroscopic studies and elemental ana

ISSN:0022-152X    

DOI:10.1002/jhet.5570180111

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA new synthesis of 7‐bromo‐1,3‐dihydro‐3‐hydroxy‐5‐(2′‐pyridyl)‐2H‐1,4‐benzodiazepin‐2‐one (5) is described. Starting from bromazepam (3), C(3) acylation with lead tetraacetate/potassium iodide in acetic acid affords4, while its mild hydrolysis according to our recently described method (5) gives5. Improved hexamine cyclization of1into3,viaquaternary hexaminium salt2, is discussed, and identification of the intermediates7and8is performed. Compound5undergoes on melting, or on brief heating in glacial acetic acid, the thermal rearrangement into quinazolin‐2‐aldehyde (13), the structure of which is confirmed by oxidation into the ester14, which in turn was hydrolyzed to the acid15. The same compound (5) rearranges on heating with manganese(III) acetate in acetic acid into the 3‐amino‐2‐quinolone derivative6. On heating in glacial acetic acid in the presence of lead tetraacetate/potassium iodide (or iodine), compound4, in addition to giving the aldehyde13, ester14and acid15rearrangement products, affords 1,2

ISSN:0022-152X    

DOI:10.1002/jhet.5570180112

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractTreatment of 1,1‐dimethyl‐2‐tolylpiperidinium halides with sodium amide in liquid ammonia affords derivatives of 2,3,4,5,6,7‐hexahydro‐1H‐2‐benzazonineviathe Sommelet‐Hauser rearrangement. Structures of the reaction products have been established by13C nmr. In the case of 1,1‐dimethyl‐2‐benzylpiperidinium halide, only an elimination

ISSN:0022-152X    

DOI:10.1002/jhet.5570180113

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractReaction of 2,4‐dichlorothienopyrimidines and ‐quinazolines1with sodium borohydride gave the corresponding 2‐chloro‐3,4‐dihydro derivatives2.Some nucleophilic substitutions of2bafforded 2‐substituted derivatives3b‐7band reaction of2g,hwith ethyl bromoacetate yielded selectively the corresponding 3‐substituted compounds8g,hwhich were derived to imidazo[2,1‐b]quin

ISSN:0022-152X    

DOI:10.1002/jhet.5570180114

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA new synthetic method for the construction of the berbine, 6‐azaberbine, and indoloberbine ring skeletons is reported. Treatment of heterocyclic bases such as isoquinolines, phthalazines, and ellipticine with 2‐chloromethylbenzoyl chloride and trimethylsilyl cyanide gave the corresponding Reissert compounds. Treatment of these Reissert compounds with sodium hydride resulted in intramolecular cyclization with loss of hydrogen cyan

ISSN:0022-152X    

DOI:10.1002/jhet.5570180115

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractEnhanced reactivity of the methyl group of 2‐t‐butyl‐5‐methyl‐1,3,4,6,9b‐pentaazaphenalene allowed acetic anhydride‐catalyzed condensation reactions with several aromatic aldehydes, and base‐catalyzed alkylation reactions with several alkyl halides to take place, albeit in low yields. Of the many nucleophiles tried, only salts of carboxylic acids, in the presence of 18‐crown‐6, were able to displace bromine from 2‐(bromomethyl)‐5‐methyl‐1

ISSN:0022-152X    

DOI:10.1002/jhet.5570180116

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe synthesis of a series of derivatives of 2,3,8,9‐tetrahydro‐3‐oxo‐1H‐benz[de]isoquinoline‐1,9a‐(7H)dicarboximide (1) are described. Alkylations and thionations of1produced a variety of interesting heterocycles. In addition, triazole and triazolone rings were fused to1to produce novel compounds. These structures were of interest as potential an

ISSN:0022-152X    

DOI:10.1002/jhet.5570180117

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA general synthetic route to 1‐alkyl and 1,3‐dialkyl‐2‐benzimidazolones from 1‐alkenyl‐2‐benzimidazolones using phase‐transfer catalysis conditio

ISSN:0022-152X    

DOI:10.1002/jhet.5570180118

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe syntheses of different 2‐(N‐tosyl‐ orN‐phthalyl‐ or free aminoacyl orN‐tosyltripeptide)‐aminophenazines, and the corresponding derivatives of 2‐aminonaphthophenazines and some derivatives of 4‐aminophenazones (IV‐XXXIII) are described. Compounds XI‐XIII, XX‐XXIII, XXX‐XXXII, XXXIV‐XXXIX and XL‐XLV were found to be active again

ISSN:0022-152X    

DOI:10.1002/jhet.5570180119

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

Abstract5,5‐Pentamethylene‐3‐(phenyl orpara‐substituted‐phenyl)‐Δ2‐1,2,4‐oxadiazolines,1a‐e, were examined by electron‐impact mass spectrometry. Defocussed metastable ion detections confirmed the formation of certain daughter fragments from the mother ions. The exact mass measurements helped to make the correct assignment of various species. We conclude that it is the spiro arrangement which caused such a dramatic change in the decomposition pattern. Several new fragmentation pathways have been found in the present studies. Out of five oxadiazolines prepared for the present work, th

ISSN:0022-152X    

DOI:10.1002/jhet.5570180120

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY