摘要:

AbstractTotal spectral assignment of the bis‐indole alkaloid Navelbine®, 5′‐nor‐anhydrovinbIastine, was accomplished using a combination of two‐dimensional nmr techniques. Conventional homonuclear and inverse‐detected experiments were supplemented with the HMQC‐TOCSY experiment to unequivocally assign carbons directly bound to overlapped protons. In addition, the recently introduced GEM‐COSY experiment was evaluated as a technique for the identification of geminal methylene pairs. Partial assignments proposed by Potier and co‐workers, based on chemical shift considerations, are largely in agreement with the unequivocal assignments determ

ISSN:0022-152X    

DOI:10.1002/jhet.5570290151

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractAlternate routes for the reductive cyclisation of 4‐acetyl‐3‐methyl‐5‐(2‐nitrophenyl)‐1‐phenylpyrazole under different conditions are described. Whereas 3,4‐dimethyl‐1‐phenylpyrazolo[4,3‐c]quinoline 5‐oxide is formed by mild noncatalytic reductions, catalytic and transfer hydrogenation processes cause the diastereoselective formation ofcis‐4,11‐dihydro‐3,5‐dimethyl‐1‐p

ISSN:0022-152X    

DOI:10.1002/jhet.5570290152

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY