摘要:

AbstractThe cyclization of enamines derived from β‐aminoesters and β‐aminonitriles into bi‐ and tricyclic enaminoketones (6,9,13and24) has been investigated. The enamines derived from aminonitriles cyclize smoothly with magnesium perchlorate in benzene or toluene, whereas the enamines derived from aminoesters cyclize spontaneously during their formation. The scope and limitation of this process is di

ISSN:0022-152X    

DOI:10.1002/jhet.5570050201

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractA series of oximes of substituted 2‐pyridylmethyl and phenyl ketones has been prepared. These all contain the ferroin group (NCCN). The 4‐substituted pyridyl‐syn‐methyl and phenyl ketoximes form che

ISSN:0022-152X    

DOI:10.1002/jhet.5570050202

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe title compounds have been prepared as analytical standards for the identification of chlorpromazine metabolites in biological materials. Unequivocal structural proof of key compounds was accomplished by using at least two unrelated syntheses for each one. Resistance of some phenothiazines to preparation via classic Smiles rearrangement is discussed. More examples are offered of halogen‐induced Smiles rearrangement. A rare example of phenothiazine polymorphism is presente

ISSN:0022-152X    

DOI:10.1002/jhet.5570050203

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractPyrrolo[2,1‐c][1,2,4]benzothiadiazines have been prepared from the reactions ofo‐amino‐benzenesulfonamides with γ‐cyanopropionaldehydes. Pyrrolo[1,2‐a]quinazolines have been prepared from the reaction of anthranilamides with either γ‐cyanopropionaldehyde or succinic anhydride. The cyclization of a 4‐oxo‐2‐quinazolinepropionic acid has produced a pyrrolo‐[1,2‐a]quinazoline and the isomeric py

ISSN:0022-152X    

DOI:10.1002/jhet.5570050204

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

Abstract2‐Quinazolinepropionic acids have been obtained from the reactions of potassium cyanide witho‐carboxy‐ oro‐acyl‐3‐chloropropionanilides. Some of these compounds have been cyclized to pyrrolo [1,2‐a] quinazolines. The reaction of ano‐carbethoxy‐2‐chloroacetanilide with potassium thiocyanate formed a 2‐quinazolinylthioacetic acid, which was cyclized to a thiazolo‐[3,2‐a]quinazoline. A mechanism is presented for the for

ISSN:0022-152X    

DOI:10.1002/jhet.5570050205

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractA total of seven thiophene derivatives not previously reported have been preparedviathe Knoevenagel condensation of an activated methylthiophene and a heterocyclic or aromatic aldehyde. The principal peaks in the ultraviolet and visible absorption spectra as well as some nuclear magnetic resonance data are reported for these compounds.

ISSN:0022-152X    

DOI:10.1002/jhet.5570050206

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractAddition of sodium nitrite to a mixture of hydrochloric acid and 1‐methyl‐5‐amino‐4‐pyrazolecarboxamide, at either high or low temperature, yielded 1‐methyl‐4‐hydroxypyrazolo‐[3,4‐d]‐v‐triazine. On the other hand, addition of hydrochloric acid to an aqueous mixture of sodium nitrite and 1‐methyl‐5‐amino‐4‐pyrazolecarboxamide gave, at high temperature (˜ 100°), 1‐methyl‐5‐nitro‐4‐pyrazolecarboxylic acid and at low temperature (˜ 0°), 1

ISSN:0022-152X    

DOI:10.1002/jhet.5570050207

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThis paper describes the synthesis of various picryl‐and picrylamino‐substituted 1,2,4‐triazoles and 3,3′‐bi‐1,2,4‐triazolyls. These compounds were prepared by condensing the appropriate 1,2,4‐triazole or amino‐1,2,4‐triazole with a picryl halide. The proton n.m.r. spectra, crystal densities, thermal stabilities, and drop‐weight impact sensitivities of the resulting comp

ISSN:0022-152X    

DOI:10.1002/jhet.5570050208

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

Abstract2‐Pyridylethylcarbinol (I) has been resolved and the antipodes hydrogenated as free bases. The (+) form gave (+) conhydrine (II) while the (‐) form afforded the levorotatory base stereoselectively with minor contamination of the other epimer. Hydrogenation ofracemicI as well as of 2‐pyridyl ethyl ketone in acid solution led formerly to the mixture of both race

ISSN:0022-152X    

DOI:10.1002/jhet.5570050209

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe preparation of triazinone (I) from certain isocyanates andN‐alkyl azomethines was found to proceed easily without catalyst, particularly in refluxing chlorobenzene. The physical and chemical properties, including n.m.r. spectra of the oily triazinones, are contrasted with the newly discovered solid adducts arising from low temperature reaction of azomethine and chlorophenyl isocyanates. From stoichiometry of the reaction, elemental analysis, molecular weight of the products, and spectral analyses, the new materials (II) were found to incorporate two isocyanate and three azomethine moieties in their molecular make‐up. The relative merits are considered for assigning II a molecular structure arising from a complex between a four and six‐membered ring (III, IV) versus a ten‐membered ring system (V, V

ISSN:0022-152X    

DOI:10.1002/jhet.5570050210

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY