摘要:

AbstractA series of 2,3‐substituted 1‐phenylbenzo[f]quinolines was synthesized by the Friedlander condensation of 1‐benzoyl‐2‐naphthylamine with β‐keto esters. Some chemical transformations of these compounds and the preparation of 13H‐benzo[f]indeno[2,1‐c]quinoline‐13‐one and its 9‐methyl de

ISSN:0022-152X    

DOI:10.1002/jhet.5570050301

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractBy reaction of the appropriate 2‐(ω‐chloroalkyl)benzimidazoles with thiourea, 2‐(α‐mercaptoalkyl)benzimidazoles (IV) have been prepared. The attempted preparation of 2‐(β‐ and γ‐mercaptoalkyl)benzimidazoles failed. β‐Elimination was observed by alkaline treatment ofS‐[2‐(2‐benzimidazolyl)‐propyl]isothiuronium chloride (VII), whereas 2‐(γ‐chlorobutyl)benzimidazoles did n

ISSN:0022-152X    

DOI:10.1002/jhet.5570050302

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe kinetics of the reactions of piperidine with 2‐bromo‐3,5‐dinitrothiophcne (IV) and 2‐bromo‐3,5‐dinitro‐4‐methylthiophene (III) have been measured in methanol, ethanol and benzene.Molecular model predictions were confirmed when the kinetic results (kIV/kIII≅ 2) demonstrated, for the first time, the absence of secondary steric effects for nucleophilic substitutions in th

ISSN:0022-152X    

DOI:10.1002/jhet.5570050303

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractDibenz[b,f]oxepin undergoes nitration and acid‐catalyzed deuteration at the 10‐position and adds bromine across the 10,11 bond. These reactions contradict predictions made by the SCFMO method. Chemical reactions and NMR spectroscopy suggest that dibenz[b,f]oxepin is only weakly aroma

ISSN:0022-152X    

DOI:10.1002/jhet.5570050304

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe partial Lossen degradation of the hydroxamic acid group at C‐4 or C‐5 of sodium 4,5‐thiazoledicarbohydroxamate (IIIb) and its 2‐methyl analog (IIIe) initiated a multicoursed reaction which furnished a mixture of thiazolo[4,5‐d]‐ and thiazolo[5,4‐d]‐N‐hydroxyuracils. The isomer distribution was sensitive to the solvent systems in which these reactions were carried out. The structure of the isomers so obtained was established by chemical and

ISSN:0022-152X    

DOI:10.1002/jhet.5570050305

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe Friedel Crafts reaction of propylene oxide with benzene has been reinvestigated, and under anhydrous conditions the product is 2‐phenylpropano

ISSN:0022-152X    

DOI:10.1002/jhet.5570050306

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe Friedel Crafts reaction of propylenimine with symmetrical arenes in the presence of aluminum chloride was investigated. Electron donating substituents increase the α‐methyl‐β‐phenethylamine/ β‐methyl‐β‐phenethylaimine ratio, while increasing the temperature has the opposite effect. In the reaction of chlorobenzene or toluene with aziridine, the nature of the substituent has little effect on the

ISSN:0022-152X    

DOI:10.1002/jhet.5570050307

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe molecular structure of 6‐(p‐bromobenzoyl)‐6‐azabicyclo[3.1.0]hexane has been determined by a single crystal, three‐dimensional x‐ray study. The compound crystallizes in the monoclinic space group (P 2 1/c) with four molecules in a unit cell of dimensions a = 8.83, b = 10.15, c = 12.63 ± 0.02Å and β = 94°55′ ± 5′. The aziridine ring is eis fused to the cyclopentane ring with the two rings together in a boat conformation. The fusion angle of the two rings is 110.8°. The aziridine ring has all angles of 60 ±1° and all bond distances of 1.48 ± 0.03Å. The cyclopentane ring has alternately long (1.61 ± 0.04Å) and short (1.52 ± 0.02Å) distances. Non‐fusion angles in the cyclopentane ring are 106.0 ± 0.5°. Other molecular parameters are as anticipated. The 844 independent reflections obtained were refined to a final value of R = 0.116using

ISSN:0022-152X    

DOI:10.1002/jhet.5570050308

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

Abstract6‐Azidotetrazolo[1,5‐b]pyridazine (III) has been prepared by two different routes and is easily transformed into the 6‐amino derivative (IV). The attempted cyclization of 6‐hydrazinotetrazolo[1,5‐b] pyridazine (II) into the postulated tricycle has been shown to result in the formation of 6‐azido‐s‐triazolo [4,3‐b]pyridazine (VI), obtained also in a separate experiment from VII. The azido structure of VI has been confirmed from spectroscopic data and from its conversion into 6‐amino‐s‐triazolo [4,3‐b]pyridazine (VIII), obtained in another experiment from VII. Similarly, cyclization of II with cyanogen bromide resulted in the simultaneous formation of thes‐triazolo ring and ring opening of the fused tetrazolo ring, giving IX. For 6‐azido‐2‐phenylimidazo[1,2‐b]pyridazine (XII) the expected a

ISSN:0022-152X    

DOI:10.1002/jhet.5570050309

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY

摘要:

AbstractThe preparation of a variety of novel 1‐aryl‐4,6‐diamino‐1,2‐dihydro‐s‐triazines is described. These compounds exhibit an array of contrasting effects on intestinal helminths, bacteria, and dihydrofolic reductase. It is concluded that potent anthelmintic activity among the dihydro‐triazines is not dependent solely on the bulky‐substituent hypothesis advanced by other investigators, and indeed cannot reliably be predic

ISSN:0022-152X    

DOI:10.1002/jhet.5570050310

出版商:Wiley‐Blackwell    

年代:1968

数据来源: WILEY