摘要:

AbstractA new and general synthesis of 2,l‐benzisothiazolin‐3‐ones (2) is described from the corresponding isatoic anhydride (3) and potassium hydrogen sulfide which gives the thioanthranilic acid (4) which is readily oxadized and ring closed to2with hydrogen peroxide. Phosphorus oxy‐chloride converted 3‐hydroxy‐2,1‐benzisothiazole to 3‐chloro‐2,1‐benzisothiazole which gave a number of different 3‐substiluted 2,1‐benzisothiazolesby nucleophilic substitution of the 3‐chloro group. Rleetrophilie substitution of 1‐methyl‐2,1 ‐benzisothiazoIin‐3‐one (2i) proceeded readily to give the corresponding 5‐bromo‐, 5‐nitro‐, and 5‐chlorosulfonyl‐1‐methyl‐2,1‐benzisothiazolin‐3‐one. This appears to be a goo

ISSN:0022-152X    

DOI:10.1002/jhet.5570150401

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractA new synthesis of pyrrolo[3,2‐b] pyridine starting with pyrrole ring is described. The procedure allows the synthesis of 4‐azaindoles bearing a sensitive group at C‐7. The nitration of4bwith nitric acid and acetic anhydride at −15° gave5. The hydrogenation of5led to simultaneous reduction ofN‐hydroxy and nitro groups and to hydrogenolysis of the isoxazole nucleus, affording an appropriate chain of atoms to building up the pyrrolo[3,2‐b] p

ISSN:0022-152X    

DOI:10.1002/jhet.5570150402

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe13C nmr ehemieal shifts of 1,2,3,4‐tetrahydroisoquinoline, salsolidine and laudanosine are reported. The various carbon resonances have been assigned on the basis of chemical shift theory, intensity of the signals, multiplicities generated in SFORD spectra and the comparison with model compound

ISSN:0022-152X    

DOI:10.1002/jhet.5570150403

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe mechanism of cyelizalion of 2‐nitrophenylhydrazine to 1‐hydroxybenztriazole in alkaline aqueous solutions is studied. Kinetic parameters, product distribution and activation parameters are determined. A mechanism involving direct attack of the β‐hydrazino nitrogen on the nitrogen ol the nilro group with elimination of water is postulated. Substituted 2‐nitrophenylhydrazines are synthesized and studied under the same co

ISSN:0022-152X    

DOI:10.1002/jhet.5570150404

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractA general method tor the preparation of 1,4‐dihydro‐4‐quinolone‐2‐carboxylic acids, especially those which carry alkyl substituents on the ringN‐atom, i

ISSN:0022-152X    

DOI:10.1002/jhet.5570150405

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

Abstractα‐Subslituted β‐2‐(5‐nitrofuryl)viriylamines were synthesized from α‐ary]‐β‐2‐(5‐nitrofuryl)‐aeryloyl azides andN‐[α‐substituled β‐2‐(5‐ni

ISSN:0022-152X    

DOI:10.1002/jhet.5570150406

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractSulfur bridging of biphenyl (4), 4‐methylbiphenyl, and the biphenylthiol isomers (7) to yield dibenzothiophene (3) is effected by means of hydrogen sulfide, benzene (solvent), and a sulfided cobaltous oxide‐molybdic oxide‐alumina (CMA‐1) catalyst at 450° in a flow system. Alumina also catalyzes a number of these transformations. The possibility that compounds7(especially the 2‐isomer) are intermediates in the conversion4

ISSN:0022-152X    

DOI:10.1002/jhet.5570150407

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractAn efficient synthesis of the sulfamylurea, Gliamilide®, is described, which involves as a key feature the selective reduction of the more basic alkyl‐substituted pyridine ring in the mono‐hydrochloride salt of dipyridyl compound11to form12without affecting the 2‐methoxy‐nicotinamid

ISSN:0022-152X    

DOI:10.1002/jhet.5570150408

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractSynthesis of 7‐methoxy‐2‐methyl‐3,5,8‐isoquinolinetrione from either 7‐ or 8‐isoquinolinol is described. 3,5,8‐Isoquinolinetrione is a novel heteroeyelic quinune which constitutes the aromatic carbon skeleton

ISSN:0022-152X    

DOI:10.1002/jhet.5570150409

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractA method for the synthesis of 2‐henzimidazolone (1) has been devised which does not depend on 1,2‐diaminobenzene (2) as a starting material. This method produces1in good yield by the reaction of hypohalite with 2′‐carbamoylphthalanilic acid (7), a compound readily prepared by the reaction of 2‐aminobenzamide (3) and phthalic anhydride. Contrary to prior indications1can be hydrolyzed in the presence of acid at temperatures greater than 200 giving excellent y

ISSN:0022-152X    

DOI:10.1002/jhet.5570150410

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY