摘要:

Abstract7‐Amino‐3‐β‐D‐ribofuranosyl‐3H‐imidazo[4,5‐b]pyridine (III, 1‐deazaadenosine) was synthesized in 32% yield from the diacetyl derivative prepared from 7‐aminoimidazo[4,5‐b]pyridine (1‐deazaadenine) and 1,2,3,5‐tetra‐O‐acetyl‐β‐D‐ribose by the fusion method. A synthesis of 7‐amino‐4‐b̊‐D‐ribofuranosyl

ISSN:0022-152X    

DOI:10.1002/jhet.5570090301

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractN‐Methoxy methyl sulfates of 2,3,4,5‐ and 2,3,5,6‐tetrachloropyridine, 3,4,5‐ and 3,4,6‐trichloropyridazine, pentachloropyridine, and tetrachloropyridazine have been prepared. Their reactions with water and aqueous potassium cyanide have been inv

ISSN:0022-152X    

DOI:10.1002/jhet.5570090302

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractThe alkylation of phenanthridone and some nuclear‐substituted phenanthridones using sodium hydride in DMF/benzene is reported. Various 5‐cyanoalkylphenanthridones were converted to further derivatives by either hydrolysis or reduct

ISSN:0022-152X    

DOI:10.1002/jhet.5570090303

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractA more practical synthesis of homopteroic and homofolic acids involving condensation of 2,4,5‐triamino‐6(1H)pyrimidinone (3) with 1‐acetoxy‐4‐[N‐acetyl‐(p‐carbethoxyphenyl)amino]‐2‐butanone (7) is described. The biological activities of homofolic (1‐b) and homopteroic (2‐b) acids were compared and found to be identical with the activities of these products prepared b

ISSN:0022-152X    

DOI:10.1002/jhet.5570090304

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractA direct and short route to the synthesis of 4‐aryloxymethyl‐δ3‐chromenes and 3‐(β‐aryloxy)‐ethylbenzofurans is described. Hydration of I,4‐diaryloxy‐2‐butynes with mercuric oxide and sulfuric acid affords, instead of a ketone, the cyclization product of the ketone. In three of the diaryloxy‐butynes studied, the corresponding aryloxyethylbenzofurans are formed. In no instance could the ketone be isolated from t

ISSN:0022-152X    

DOI:10.1002/jhet.5570090305

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractCarbamate esters of 4‐hydroxycoumarin were prepared, and their base‐catalyzed and thermal rearrangement to 3‐(N‐substituted carbamoy])‐4‐hydroxycoumarins were studied. A mechanism for the rearrangement

ISSN:0022-152X    

DOI:10.1002/jhet.5570090306

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractThe behaviour under electron impact of sixteen thiazoloquinolines, unsubstituted and containing methyl substituents in both the pyridine and the thiazole rings, was investigated. Some decomposition schemes related to the main fragmentations in these fused heteroaromatic systems are proposed on the basis of available results on simpler related structures like thiazoles, benzo‐thiazoles and quinoline

ISSN:0022-152X    

DOI:10.1002/jhet.5570090307

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractFragmentation patterns of tropane and tropidine derivatives have been shown to depend on the nature of the substituents. Unsaturation in the 6‐membered ring leads to preferential fragmentation of the two carbon bridge. When the 6‐membered ring is saturated and substituted with poor leaving groups (OH and CN) fragmentation of the 6‐membered ring is pref

ISSN:0022-152X    

DOI:10.1002/jhet.5570090308

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractEthyl 3‐amino‐4,4,4‐trifluorocrotonate (3) has been converted by a one step reaction with alkyl and aryl isocyanates to novel 3‐substituted‐6‐(trifluoromethyI)uracils. Also several 3‐amino‐4,4,4‐trifluorocrotonitriles (11a‐c) have been cyclized to novel 6‐(trifluoromethyI)cytosines (13a‐c) and then hydrolyzed to the corresponding uracils (4, 14b‐c). Alkylation studies with isopropyl bromide of three 6‐(trifluoromethyl)urac

ISSN:0022-152X    

DOI:10.1002/jhet.5570090309

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY

摘要:

AbstractA series of α,α ‐dimethoxydihydrofurans have been prepared and subjected to various acidic and neutral hydrolysis conditions in attempts to prepare conjugated enediones in a stereospecific manner. Isomerization of the 3‐hexene‐2,5‐diones and rearrangements of other enediones to β,γ‐unsaturated‐γ‐lactones have been uncovered. Methods of assignment of stereochemical configuration to the enediones are evaluated; reaction with hydrazine hydrate in the absence of acid is proposed as

ISSN:0022-152X    

DOI:10.1002/jhet.5570090310

出版商:Wiley‐Blackwell    

年代:1972

数据来源: WILEY