摘要:

AbstractNovel syntheses of thiophene fused tricyclic systems1and2are reported. The methods use intermediates 4‐ethoxy‐3‐thiopheneamine, 4‐ethoxy‐3‐thiophenecarbonyl aside and 4‐ethoxy‐3‐thiophenecarbonyl chloride to effect selective, high yield syntheses of the target compounds in two steps. These methods allow preparation of thiophene systems without substitution at the normally reactive C‐

ISSN:0022-152X    

DOI:10.1002/jhet.5570170701

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractTreatment of 6‐amino‐5‐arylazo‐1,3‐dimethyluracils with urea orN,N′‐carbonyldiimidazole gave the respective 6‐aryl‐1,3‐dimethyl‐6,7‐dihydro‐6‐azalumazin‐7‐(6H)ones, which were hydrolyzed with alkali to afford 2‐aryl‐2,3,4,5‐tetrahydro‐3,5‐dioxo‐1,2,4‐triazine‐6‐carboxylic acids (1‐aryl‐6‐azauracil‐5‐carboxylic acids). Thermal decomposition of these carboxylic acids gave the corresponding 2‐aryl‐1,2,4‐triazine‐3,5‐(2H,4H)diones (1‐aryl‐6‐azauracils). Methylation of the latter with methyl iodide gave the corresponding 2‐

ISSN:0022-152X    

DOI:10.1002/jhet.5570170702

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractSeveral 5‐(1‐naphthylmethyl)‐4‐aryl‐s‐triazol‐3‐thiols/ylthioglycolic acids were synthesized as possible anti‐inflammatory agents. The interpretation of infrared, nuclear magnetic resonance, and mass spectra is discussed for chemical characterization o

ISSN:0022-152X    

DOI:10.1002/jhet.5570170703

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe electric dipole moment of 5‐(p‐tolyl)tetrazole in dioxane at 30.0° (4.99 D) suggests that the compound is a mixture of the 1H‐tautomer (60 ± 10%) and the 2H‐tautomer (40 ± 10%) in this medium. This determination was made by taking μ (2H) as μ (2Me) = 2.41 D in benzene, and by taking μ (1H) as μ (1Me) = 6.03 D in benzene with due allowance being made for the presence of interannular conjugation in the 1H‐tautomer but not in the 1‐methyl isomer. The dipole moments of 1‐methyl‐5‐(p‐tolyl)tetrazole and 2‐methyl‐5‐(p‐tolyl)tetrazole were also measured in dioxane; that of 1,5‐trimethylenetetrazole was measured in benzene. Comparison with relevant data for unsubs

ISSN:0022-152X    

DOI:10.1002/jhet.5570170704

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe reaction of 2‐fluoro‐1,1‐dimethoxy‐3‐methylbut‐2‐ene (3) with phenols in dry pyridine leads to 3‐fluoro‐2,2‐dimethyl‐2H‐chromenes. 3‐Fluoro analogues of the natural insect antijuvenile hormones Precocene I (1a) and II (1b) have bee

ISSN:0022-152X    

DOI:10.1002/jhet.5570170705

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractL'addition de la méthyl‐2 oxaxoline‐1,3 (1a) sur la propanesultone‐1 (3) (2) conduit à un composé ionique de type sulfobétaïne4aque nous avons caractérisé par spectroscopie. La structure proposées est confirmée par quelques réactions chimique

ISSN:0022-152X    

DOI:10.1002/jhet.5570170706

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe reaction of 2‐amino‐1,1‐dicyanobut‐1‐ene and 2‐amino‐1,1‐dicyano‐2‐phenylethene, respectively, withN,N‐dimethylformamide dimethylacetal provided the corresponding (N,N‐dimethylaminomethylene)amino derivatives. 2‐[(N,N‐Dimethylaminomethylene)amino]‐1,1‐dicyano‐2‐phenylethene was converted into 4‐amino‐5‐cyano‐6‐phenylpyrimidines by treatment with primary aliphatic and aromatic amines. The structure of the reaction

ISSN:0022-152X    

DOI:10.1002/jhet.5570170707

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractA number of 1‐alkyl‐2‐carbomethoxy(benzyloxy)‐4‐methylazetidines have been prepared by reaction of primary amines with α,γ‐dibromo esters. Only one isomer was isolated from the reaction mixture. α‐Aminolactones can also be obtained as the minor product of the r

ISSN:0022-152X    

DOI:10.1002/jhet.5570170708

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractSeveral 1‐(5‐aryl‐2H‐tetrazol‐2‐ylacetyl)‐4‐substituted thiosemicarbazides and 5‐(5‐aryl‐2H‐tetrazol‐2‐yl‐methyl)‐4‐substituted‐s‐triazole‐3‐thiols were synthesized as possible antiinflammatory agents. These compounds were characterized by their elemental, infrare

ISSN:0022-152X    

DOI:10.1002/jhet.5570170709

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe nitration and bromination of both [1]benzothieno[3,2‐d]pyrimidin‐4(3H)one (1) and [1]benzothieno‐[3,2‐d]pyrimidine (2) has been studied. Nitration of1at −30° afforded a mixture of 8‐nitro[1]benzothieno‐[3,2‐d]pyrimidin‐4(3H)one (7b) (70%) and 6‐nitro[1]benzothieno[3,2‐d]pyrimidin‐4(3H)one (7a) (30%). However when the nitration was carried out at 60°, the 6,8‐dinitro derivative8was the result. On the contrary, the nitration of2at −30° gave a single nitration product, 8‐nitro[1]benzothieno[3,2‐d]pyrimidine (11). The bromination of both1and2gave the corresponding 8‐bromo derivatives10and13. Assignment of structure of all the products was based on ir and nmr spectral

ISSN:0022-152X    

DOI:10.1002/jhet.5570170710

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY