ISSN:0022-152X    

DOI:10.1002/jhet.5570100601

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe synthesis and reactions of dimethyl 3, 4‐ and 4, 5‐diaminophthalate7and9were investigated. The condensation of these isomeric diaminophthalates and their respective nitroacetamido precursors have been shown to give rise to a variety of five, six and seven membered heterocyclic ring system. Several new tetraazanthracenes have also been prepared in this seque

ISSN:0022-152X    

DOI:10.1002/jhet.5570100602

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

Abstract1, 2‐Dimethyl‐5‐nitroimidazole(1)andN,N‐dimethylformamide dicyclohexylacetal gave the 2‐(β‐dimethylaminovinyl) analog2and with iodine and pyridine gave the 2‐(1‐pyridinium)methyl compound3. Benzoyl chloride‐triethylamine and 1 led to benzoylation of the 2‐methyl group to give ketone9as the enol benzoate. Nitrous acid or nitrosylsulfuric acid with9or its enol ester afforded the oximinoketone10which was cleaved with thionyl chloride to give 2‐cyano‐1‐methyl‐5‐nitroimidazole (11) in high overall yield. 1‐Ethyl‐2‐methylbenzimidazole (22) was converted to 2‐cyano‐1‐ethylbenzimidazole (25) similarly. Reaction of1with ethyl oxalyl chloride and triethylamine afforded ethyl 1‐methyl‐5‐nitro‐2‐imidazolepyruvate (19) as the enol oxalate. Nitrous acid and19gave the oximino pyruvate20which effervesced on mild heating to give 2‐cyano‐1‐methyl‐5‐nitroimidazole (11). The preparatio

ISSN:0022-152X    

DOI:10.1002/jhet.5570100603

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe synthesis of dimethylarsinothio‐and dimethylarsinoselonopyrimidines and ‐purines which utilizes diethylaminodimethylarsine is described. A series of these derivatives, with different substituents on the heterocyclic ring, has been investigated by infrared, nmr, and mass spectroscopic methods. Attempts to prepareO‐orN‐ arsinous acid derivatives from oxy‐ and aminopyrimidines were uns

ISSN:0022-152X    

DOI:10.1002/jhet.5570100604

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractCyclization of benzoyl derivatives ofN‐substituted trimethylenediamines with polyphosphoric acid or the corresponding ethyl ester, afforded 1, 2‐disubstituted‐1, 4, 5, 6‐tetrahydropyrimidines.PPEwas the more advantageous reagent. The excessive protonation of the starting material and the cleavage of the ether function produced byPPAexplains the failure of this reagent to cause ring closure in some cases. Synthesis of the starting materials is described. Analytical and spectroscopic data of the new compounds are pr

ISSN:0022-152X    

DOI:10.1002/jhet.5570100605

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractFive minor prodiginine pigments were isolated fromActinomadura maduraeandA. pelletierifermentations. Two of the pigments were shown to be methylcyclooctylprodiginine (7) and ethylcyclononylprodiginine (8). For the others, structures containing oxygen functions in the aliphatic chains (11,12and13) were suggested.

ISSN:0022-152X    

DOI:10.1002/jhet.5570100606

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractIn a previous paper it was reported that N′‐alkyl derivative of isonicotinic acid hydrazide (INH) was more active against tuberele bacilli than the acyl derivative containing the same number of carbon atoms. The authors subsequently reported that the pyrido[2, 3‐d]pyridazine was closely related to the acyl derivative of INH except that the terminal carbonyl group was cyclized to the pyridine nucleus, therefore these derivatives were not effective against tubercle bacilli; however, pyridopyridazine, which is similar to the alkyl derivatives of INH, will be more effective against tubercle bacilli. According to the similar expectation, some pyrazolopyridines were pre

ISSN:0022-152X    

DOI:10.1002/jhet.5570100607

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe treatment of 3β‐hydroxy‐16α‐bromo‐5α‐androstan‐17‐one, 3β‐acetoxy‐16α‐bromo‐5‐androsten‐17‐one and 21‐bromo‐5‐pregnen‐3β‐ol‐20‐one with 4,5‐dimethyl‐o‐phenylenediamine gave substituted quinoxalines.Hydrolysis of 3β‐acetoxy‐5‐androsteno[16,17‐b]‐6′,7′‐dimethylquinoxaline produced the corresponding 3β‐hydroxy compound. 3‐Oxo‐4‐androsteno[16,17‐b]‐6′,7

ISSN:0022-152X    

DOI:10.1002/jhet.5570100608

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractCrystalline samples of DL‐2‐phenoxy melhylpenicillenic acid (14) and ofDL‐2‐(2, 6‐dimethoxyphenyl)penicillenic acid (21) have been synthesized by the reaction ofDL‐penicillamine with 2 phenoxymethyl‐4‐(methoxymethylene)oxazol‐5‐one and 2‐(2, 6‐dimethoxyphenyl)‐4‐(ethoxymethylene)oxazol‐5‐one, respectively. These key oxazol‐5‐one intermediates were synthesized by azlactonization of the appropriately substituted penaldic acid dialkyl acetals. The reaction of mercury(II) chloride with D‐phenoxymethylpenicillin was studied and found to be inapplicable to the synthesis ofD‐14. A comparison of crystallineDL‐ and of amorphous D‐2‐(2,6‐dimethoxyphenyl)penicillenic acid (21), which were prepared by the “oxazolone” and “mercury(11) chloride” methods, respectively, sugges

ISSN:0022-152X    

DOI:10.1002/jhet.5570100609

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractA series of symmetrically and asymmetrically substituteds‐triazines was synthesized by condensation of fluorocarbon nitriles (Scheme II, compounds1a‐c) and by cyclodehydration of a fluorocarbon imidoylamidine utilizing a fluorocarbon anhydride (Scheme III, compounds2a‐e). Among the new nitriles prepared for incorporation in these reaction paths were 11‐H‐4,9‐dioxahexadecylfluoroundecanenitrile (3) and 6‐chloro‐6‐H‐4‐oxaheptafluorohexanenitrile (4),

ISSN:0022-152X    

DOI:10.1002/jhet.5570100610

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY