摘要:

AbstractThe reactions of 1‐phenylphosphole (PP), 3‐methyl‐1‐phenylphosphole (mPP), 3,4‐dimethyl‐1‐phenylphosphole (dPP) and, in certain instances, 1‐n‐butyl‐3,4‐dimethylphosphole (dBP) with some transition metal chlorides and some metal‐Cl‐CO systems are reported. These reactions show that simple phospholes in general unexpectedly behave much like ordinary tertiary phosphines and that, unlike the reactions with Ni(II), Pd(II) and Pt(II), the complexes formed are conventional in most respects. However, a few unusual reactions were observed. For example, mPP partially reduces Ru(III) to give a mixed‐valent Ru(III)‐Ru(II) complex while PP reduces Ir(III) to Ir(I). From infrared spectroscopic studies of the square‐planar Rh(I) complexes L2Rh(CO) Cl (L = phosphole), it appears that donor character decreases with decreasing substitution on the phosphole ring carbon atoms. Phosphorus‐phenyl cleavage has been observed in reactions of 1‐phenylphosphole with Rh‐CO systems. The results are briefly discussed in relation to the behaviour of other phospholes in similar reactions and in the context of t

ISSN:0022-152X    

DOI:10.1002/jhet.5570150801

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractQuinazoline is oxidized by xanthine oxidase initially (and rapidly) to 4‐hydroxyquinazoline which subsequently is oxidized more slowly to 2,4‐dihydroxyquinazoline. Both oxidative reactions are inhibited strongly by allopurinol. Quinazoline is oxidized by aldehyde oxidase to 4‐hydroxyquinazoline but within a short time (3–5 minutes) the reaction ceases; the proposal that cessation of reaction is due to product inhibition is rendered untenable by our observation that 4‐hydroxyquinazoline is rapidly oxidized by aldehyde oxidase to 2,4‐dihydroxyquinazoline. Preincubation of aldehyde oxidase with quinazoline results in complete inhibition of the ability of the enzyme to oxidize 4‐hydroxyquinazoline and the standard substrateN‐methylnicotinamide. It appears therefore that quinazoline is able to react with aldehyde oxidase and inactivate it. Quinoxaline and 2‐hydroxyquinoxaline are not oxidized by xanthine oxidase but are converted by aldehyde oxidase to 2,3‐dihydroxyquinoxaline; all oxidations mediated by aldehyde oxidase are inhibited comp

ISSN:0022-152X    

DOI:10.1002/jhet.5570150802

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

Abstract1‐(α‐Benzoyloxyarylideneamino)‐4, 5‐dirnethyl‐1,2,3‐triazoles (V) were prepared by reacting the sodium salt of substituted 1‐benzoylamino‐4, 5‐dimethyl‐1,2,3‐triazoles (IV) with benzoyl chloride at −50°. The uncatalyzed thermal isomerization of isoimides V to the corresponding imides VI was studied kinetically and the reacti

ISSN:0022-152X    

DOI:10.1002/jhet.5570150803

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe acid catalyzed cyclization of isopropylidene malonate derivatives of ketones to form α‐earboxy‐γ‐lactones has been shown to occur with boron trifluoride etherate orp‐toluenesulfonic acid, as well as with concentrated sulfuric or polyphosphoric acids. A similar cyclization of a diethyl ylidenemalonate to a lactone ester, in relatively poor yield, has also been accomplished. Acid catalyzed cyclization of the ylidenemalononitrile derived from pinacolone to form an α‐carbamoyl‐γ‐lactone has been shown to occur with rearrangement. However, that derived from 2,2‐dimethyleyclohexanone cyclized to the secondary carbon of the ring without rearrangement. The isopropylidene malonate derivatives of several ring‐substituted and bridged ketones have been converted to α‐earboxy‐γ‐l

ISSN:0022-152X    

DOI:10.1002/jhet.5570150804

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractReaction of the Reissert anion with the carbonyl group of 1,3,4,6,7,11b‐hexahydro‐9,10‐dimethoxybenzo[a]quinolizin‐2‐one and with 3‐ethyl‐1,2,3,4,6,7‐hexahydro‐9,10‐dimethoxy‐11bH‐benzo[a]quinolizin‐2‐carboxaldehyde give emetine analogs. This anion does not react with the carbonyl group of 3‐aIkyl‐1,3,4,6,7,11b‐hexahydro‐9,10‐dimethoxybenzo[a]quinolizin‐2‐one but instead gives a rearrangement produ

ISSN:0022-152X    

DOI:10.1002/jhet.5570150805

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractReactions of the iminoesters3a‐cwith hydrazine or 1,2‐dimethylhydrazine gave 4,5‐dihydro‐4a‐cor 2,5‐dihydro‐1,2,4‐triazin‐6(1H) ones7a‐c, respectively. When methylhydrazine was employed, 1‐methyl‐4, 5‐dihydro‐5a‐cand 2‐methyl‐2,5‐dihydro‐1,2,4‐triazin‐6(1H) ones6a‐cwere obtained. Compounds6a‐cexist as zwitterions in

ISSN:0022-152X    

DOI:10.1002/jhet.5570150806

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe acyl thioacetanilide3condensed with 2‐bromotetralone to give the spiroketone5. A similar reaction of the tetralone with the acyl‐N‐ethylthioacetamide4afforded small amounts of the unsaturated spiroketone6with the isomeric dihydrobenz[g]indole7as the major product. Compound7was aromatized to the benz[g]indole8in high

ISSN:0022-152X    

DOI:10.1002/jhet.5570150807

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe sequential nature of the unique rearrangement‐dehydrogenation ofcis‐1‐alkyl‐2‐aryl‐3‐aroylaziridines (1a‐d) into 2‐alkylamino‐3‐arylindenones (2a‐d) when treated with a lithium amide has been established. Furthermore, a competitive degradation pathway has been discovered which leads to ω‐aminoacetophenones and benzaldehyde, thereby accounting for the major product of this reaction.trans‐1‐Alkyl‐2‐aryl‐3‐aroylaziridines do not react with the lithium amides employed in these studies. Although 1‐cyclohexyl‐2‐methyl‐3‐benzoylaziridine reacts with lithium amide to produce a 3‐carbanion, neither a rearrangement‐dehydrogenation to a 2‐aminoindenone nor a more extensive degradation involving carbon‐carbon bond cleavage is observed. Mechanistic p

ISSN:0022-152X    

DOI:10.1002/jhet.5570150808

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractPreparation and structural evidence ofN‐methyl‐(1,3‐R,R'‐pyrazol‐5‐yl)‐o‐nitrobenzamides (VIIIa, b) are discussed. Diazotisation of relatedo‐aminobenzamides XIa,b followed by the Pschorr reaction afforded a very complex mixture from which pyrazolo[3,4‐c]isoquinolin‐5‐ones XIIa.b in 7–10% yields together withN‐methyl‐(1,3‐R,R'‐pyrazol‐5‐yl)‐o‐hydroxybenzamid

ISSN:0022-152X    

DOI:10.1002/jhet.5570150809

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

Abstract2‐Amino‐5‐phenyl‐1,3,4‐oxadiazole (1a) and 2‐amino‐1,3,4‐thiadiazole (1b) reacted with acrylonitrile to yield β‐cyanoethylamino derivatives. On the other hand, 2‐amino‐4‐phenylthiazole (2) reacted with acrylonitrile under the same experimental conditions to yield a di‐β‐cyanoethylaminothiazole derivative. 3‐Phenyl‐Δ2‐1,2,4‐triazoline‐5‐thione reacted with acrylonitrile to yield the corresponding adduct. The structure of the adduct was established by its conversion into the acid13which could

ISSN:0022-152X    

DOI:10.1002/jhet.5570150810

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY