摘要:

AbstractStarting from the readily available 2‐methyl‐3‐benzoylfuran, 1‐phenylthieno[3,4‐b]furan and 1‐phenyl‐seleno[3,4‐b]furan were prepared. Also, starting from phenyl 3‐methylindol‐2‐yl ketone and aryl 2‐methyl‐indole‐3‐yl ketones a series of substituted thieno[3,4‐b]indoles and substituted sel

ISSN:0022-152X    

DOI:10.1002/jhet.5570190201

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe synthesis of urethane protected 4‐ and 5‐aminoimidazole nucleoside derivatives4and9by two different routes is described. These routes are transformation of the carboxylate substituted imidazole nucleoside1viaa Curtius rearrangement to give4and direct ribosylation of the imidazole base6to give a mixture of positional isomers7and8, which by deacetylation afford4and9, respectively. The convenience of each route depended on the positional isomer to be synthesi

ISSN:0022-152X    

DOI:10.1002/jhet.5570190202

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractA series of derivatives of 4H‐2,3‐dihydrobenzo‐1,4‐thiazine has been prepared. 4‐Acetyl‐2,3‐dihydrobenzo‐1,4‐thiazine undergoes self‐condensation byn‐butylmagnesium bromide affording the corresponding 4‐aceto‐acetyl‐2,3‐dihydrobenzo‐1,4‐thiazine, which, is converted to 5H‐1,4‐thiazino[2,3,4‐if]quinolin‐5‐one. Halogena‐tion of the acetyl derivative takes place at the position 2 of the heterocyclic ring and

ISSN:0022-152X    

DOI:10.1002/jhet.5570190203

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe total assignment of the13C‐nmr spectra of phenarsazine‐10‐chloride and several substituted analogs is reported. Spin‐lattice (T1) relaxation measurements have shown these systems to reorient anisotropically. In the case of the parent system and the 3‐chloro substituted system, the axis of anisotropic reorientation has been shown to pass approximately through the center of the molecule. In the case of benzo[c]phenarsazine‐7‐chloride, the axis of anisotropic reorientation, which has been accurately defined, is shifted 23° from that in the previous cases, the shift occurring in the direction of th

ISSN:0022-152X    

DOI:10.1002/jhet.5570190204

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractLa méthylation de l'adénine en catalyse par transfert de phase fournit sélectivement la méthyl‐9 adénine (98%), tandis que sa benzylation conduit à la benzyl‐9 adénine comme produit majoritaire à cǒté de très faibles quantités de benzyl‐3 adénine. L'alkylation de la xanthine, de la théobromine et de la théophylline par la měme technique donne naissance aussi aux dérivesN‐alkylés correspondants avec de hauts rendements à l'exclusion de tout autre régioisomereO‐alkylé. Cette technique d'alkylation constitue, tant par sa simplicité que par sa sélectivityé, une amélioration consider

ISSN:0022-152X    

DOI:10.1002/jhet.5570190205

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

Abstract1‐Triphenylmethylimidazoles are treated withn‐butyllithium in tetrahydrofuran at 0° to form the 2‐lithio derivatives. The latter species react withn‐propyl nitrate to give l‐trityl‐2‐nitroimidazoles which, after acid hydrolysis, provide the corresponding 2‐nitroimidazoles. 2‐Nitroimidazole was obtained from imidazole in overall yields of 27–35% 4‐methyl‐2‐nitroimidazole was obtained in 40% overall yield from 4‐methyl‐imidazole. Imidazole‐4,5‐dicarboxylic acid was converted, in several steps, to l‐tritylimidazole‐4‐methanol, and the latter compound was transformed into 2‐nitroimidazole‐4‐methanol in an overall yield of 18%. Protection of the hydroxymethyl function was found to be unnecessary during carbanion formation and nitration. Attempts to nitrate 1‐methylimidazole or 1‐m

ISSN:0022-152X    

DOI:10.1002/jhet.5570190206

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractCycloaddition of dichloroketene toN,N‐disubstituted (E)‐amino‐5‐methyl‐1,4‐hexadien‐3‐ones IV and (E,E)‐1‐amino‐5‐phenyl‐1,4‐pentadien‐3‐ones V occurred in moderate to good yield only in the case of aromaticN‐substitution to giveN,N‐disubstituted 4‐amino‐3,3‐dichloro‐3,4‐dihydro‐6‐(2‐methyl‐l‐propenyl) (2‐phenylethenyl)‐2H‐pyran‐2‐ones, which were dehydrochlorinated with DBN to afford in good yieldN,N‐disubstituted 4‐amino‐3‐chloro‐6‐(2‐methyl‐propenyl)(2‐phenylethenyl)‐2H‐pyran‐2‐ones. In the case of aliphaticN,N‐disubstitution (dimethylamino group) of enaminones IV and V, the Cycloaddition led directly in l

ISSN:0022-152X    

DOI:10.1002/jhet.5570190207

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractCette note traite d'une nouvelle méthode de préparation d'azotures de glycosyle sur lesquels la cycloaddition de composés acétyléniques activés pour donner des triazolo‐1,2,3 nucléosides a été améliorée. Ceci a été réalisé en séries allo‐, ribo‐ et arabinofurannoses et mannopyrannose avec le propiolate de méthyle et l'acetylene

ISSN:0022-152X    

DOI:10.1002/jhet.5570190208

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractRoom temperature treatment of 2‐(3‐arylureido)benzoic acids (1) and methyl 2‐(3‐alkyl‐, or 3‐arylureido)‐ benzoates (2) with concentrated sulfuric acid leads toN‐substituted 2‐amino‐4H‐3,l‐benzoxazin‐4‐ones (3) in generally very good yields. The isomeric 3‐substituted 2,4(1H,3H)‐quinazolinediones (4) are conveniently made in high yield by the action of aqueou

ISSN:0022-152X    

DOI:10.1002/jhet.5570190209

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

Abstract2‐Arylmethylene‐l‐indanones (I) and 2‐arylmethylene‐1,3‐indanediones (VII) react with active methylene compounds in the presence of ammonium acetate as a basic catalyst to afford substituted pyridines. The postulated routes to the formation of the reported compound

ISSN:0022-152X    

DOI:10.1002/jhet.5570190210

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY