摘要:

AbstractThe polar 1,4‐cycloaddition of sulfene toN,N‐disubstituted 6‐aminomethylene‐5,6‐dihydro‐2‐phenylbenzothiazol‐7‐(4H)ones gave, generally in good yield,N,N‐disubstituted 3,4,5,6‐tetrahydro‐8‐phenyl‐1,2‐oxathiino‐[5,6‐g]benzothiazol‐4‐amine 2,2‐dioxides, which are derivatives of the new heterocyclic system 1,2‐oxathiino‐[5,6‐g]benzothiazole. This reaction did

ISSN:0022-152X    

DOI:10.1002/jhet.5570180601

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe reaction of 3,4‐dibenzoyl‐1‐methyl‐2,5‐diphenylpyrrole (1) and ‐1‐phenylpyrazole (2) with methylamines (3a‐c) afforded pyrrolo[3,4‐c]pyridine (4), and isomeric 2H‐pyrazolo[3,4‐c]pyridines (5a‐c) and [4,3‐c]pyrid

ISSN:0022-152X    

DOI:10.1002/jhet.5570180602

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractAcid‐catalyzed condensation of a series of 3‐oxoalkanoic acid esters with aniline affords the corresponding 2‐alkyl‐4‐quinolones in good yield. Treatment of these compounds with methyl iodide affords 2‐alkyl‐4‐methoxyquinolines and 2‐alkyl‐N‐methylquinolones. Three of the compounds are naturally‐occurring alkaloids which are synthesized

ISSN:0022-152X    

DOI:10.1002/jhet.5570180603

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe behaviour of 2,1‐benzisoxazoles (anthranils) towards electrophilic substitutions has been studied. Nitration of 5‐chloro‐2,1‐benzisoxazole (VII) exclusively gives 4‐nitro‐5‐chloro‐2,1‐benzisoxazole (XII). However, 5‐chloro‐3‐phenyl‐2,1‐benzisoxazole (VIII) gives dinitrated products XIII, one nitro group entering at position C7instead of C4of the carbocyclic ring and the other at the 4′ position of the 3‐aryl ring. When 6‐nitro‐3‐carbalkoxy‐2,1‐benzisoxazoles (X and XI) are nitrated, 4‐nitroisomers XV and XVI are obtained exclusively. The substituents already present in the carbocyclic ring exert decisive directing influence. While the parent 2,1‐benzisoxazole (Ia) fails to react with dimethyl acetylenedicarboxylate, 6‐nitro‐2,1‐benzisoxazole (XVII) and 5‐chloro‐2,1‐benzisoxazole (VII) react to give 1,4‐cycloadducts XIX and XX, respectively. These results suggest that 2,1‐benziso

ISSN:0022-152X    

DOI:10.1002/jhet.5570180604

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractEthyl 2‐aminofuro[3,2‐b]pyridine‐3‐carboxylate rearranges with sodium ethoxide in ethanol to 2‐oxo‐3‐cyano‐2,3‐dihydro[3,2‐b]furopyridine; the correspondingp‐nitrophenyl ester undergoes the same rearrangement by dilute aqueous sodium hydroxide. In the first case it was possible to isolate the labile intermediate, which was shown to be the hemiacetal of the above m

ISSN:0022-152X    

DOI:10.1002/jhet.5570180605

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe reaction oftrans‐3a,4,5,9b‐tetrahydronaphth[1,2‐d]imidazoline‐2‐thiones (8) with α‐bromoketones gave, depending upon the structure of the α‐bromoketones, reaction solvent and reaction temperature, the hydrobromides of tetrahydronaphth[1,2‐d]imidazolin‐2‐ylthiomethyl ketone (10), hexahydro‐8‐hydroxynaphth[1′,2′:4,5]imidazo[2,1‐b]thiazoles (5, 11, 19and20) or tetrahydronaphth[1′,2′:4,5]imidazo[2,1‐b]‐thiazoles (12and16). Structural determinations based on

ISSN:0022-152X    

DOI:10.1002/jhet.5570180606

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

Abstract5,6‐Unsubstituted 1,3‐oxazine‐2,4‐diones (3) and 6‐unsubstituted 5‐methyl‐1,3‐oxazine‐2,4‐diones (4) were prepared by reduction of the corresponding 6‐chloro derivatives (1and2). Treatment of 6‐chloro‐3‐methyl‐1,3‐oxazine‐2,4‐dione (1a) with sodium azide, sodium cyanide, secondary amines and aniline gave the corresponding 6‐substituted compounds (7, 9, 10and11) while the reaction of1aand2a,bwith primary aliphatic amines such as methylamine and ethylamine caused a ring transformation to pyrimidine ring s

ISSN:0022-152X    

DOI:10.1002/jhet.5570180607

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractReaction of 3‐methoxy‐17‐methylmorphinan‐6‐one (1) and formaldehyde with the presence of calcium hydroxide in aqueous dioxane gave 7,7‐bis(hydroxymethyl)‐3‐methoxy‐17‐methyl‐5‐methylenemorphinan‐6β‐ol (2a). Catalytic reduction of2ayielded the 5α‐methyl compound,2b. Tosylation of2a,bfollowed by lithium triethylborohydride reduction gave either 7α‐methyl‐6β,7β‐oxetanes4a,bor 7,7‐dimethyl‐6β‐ols5a,b, depending on reaction conditions. The C‐6 ketones6a,bwere prepared by oxidation of5a,b. One compoun

ISSN:0022-152X    

DOI:10.1002/jhet.5570180608

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThermal conversion of furanendo‐peroxide I, obtained by photosensitized oxidation of furan II, yields very similar results to those of the oxidation of the furan II by thermally generated singlet oxygen, showing that also in the latter case theendo‐peroxide I is the key intermediate. A mechanistic interpretation of the furan II‐singlet oxygen reaction is rep

ISSN:0022-152X    

DOI:10.1002/jhet.5570180609

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractReaction of 5‐bromo‐1‐(p‐bromophenyl)‐2‐methylpyridazine‐3,6‐dione with morpholine leads to formation of 1‐(p‐bromophenyl)‐2‐methyl‐5‐morpholinopyridazine‐3,6‐dione. The structure of the morpholino compound was established by the chemical methods and an X‐ra

ISSN:0022-152X    

DOI:10.1002/jhet.5570180610

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY