摘要:

Abstract1‐Ureidopyrroles of type 6a,b prepared by the general method previously described (2), readily cyclized under basic conditions giving pyrrolo [2,1‐f]‐1,2,4‐triazine‐2,4(1H, 3H)dione de

ISSN:0022-152X    

DOI:10.1002/jhet.5570160501

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

Abstract2‐Nitrobenzenesulfonyl chloride reacts with ω‐aminoacetophenone and 4‐amino‐3,5‐dimethyl‐isoxazole to give 3 and 7, respectively. Reduction of 3 with zinc powder and acetic acid afforded the 2,5‐dihydro‐ and 2,3,4,5‐tetrahydro‐1,2,5‐benzothiadiazepine I,1‐dioxide derivatives (4 and 5). Catalytic hydrogenolysis of 7 and successive cyclization of the intermediate 8 gave the 3‐ace‐thyl‐2,5‐dihydro‐4‐methyl‐1,2,5‐benzothiadiazepine 1,1‐dioxide (9). The structures were assigned on the basis of correct

ISSN:0022-152X    

DOI:10.1002/jhet.5570160502

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractAus 1,4,7‐Triketonen und Hydrazin entstehen je nach den Reaktionsbedingungen Dihydro‐pyridazinhydrazone 1–8 oder Dihydropyrrolo [1,2‐b]pyridazine 9–19. Letztere werden durch Chloranil zu den Pyrrolo[1,2‐b] pyridazinen 20–

ISSN:0022-152X    

DOI:10.1002/jhet.5570160503

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe reaction of disodium cromoglycale with five cationic dyes: crystal violet, Janus green, methylene blue, methyl green, and safranine, was investigated. Spectroscopic shifts indicated that at low concentration (0.01 mM) all these dyes were able to form complexes (ion paris) with the cromoglycale anion. In addition, the complexes formed by crystal violet and Janus green were extractable into chloroform.

ISSN:0022-152X    

DOI:10.1002/jhet.5570160504

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractSeveral reactions of the pyrazoline 1a were investigated. With bromine water, potassium permanganate, hydrogen peroxide, or potassium hydroxide, different pyrazole derivatives were formed. While the reaction with hydroxylamine or some hydrazines gave the corresponding pyrazoline Schiff bases, with aroylhydrazines, pyrazole Schiff bases were formed.

ISSN:0022-152X    

DOI:10.1002/jhet.5570160505

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe structure of 1‐(p‐bromophenyI)‐5‐bromopyridazine‐3,6‐dione was unequivocally established by means of an X‐ray crystal structure determination. By the same means its reaction product with diethylamine was proved to be 1‐(p‐bromophenyl)‐4‐diethylamin

ISSN:0022-152X    

DOI:10.1002/jhet.5570160506

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractSyntheses of some hydroxylaminoazines and hydroxamic acids were investigated. For direct displacement with hydroxylamine a good leaving group, activated by other substituents, must be present.

ISSN:0022-152X    

DOI:10.1002/jhet.5570160507

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe synthesis of the novel 1,2‐dihydroindolo [1,7‐ab][1,5]benzodiazepine ring system 4 is described. Condensation of 2‐fluoronitrobenzene with indoline provided the starting material for the synthesis, 1‐(2‐nitrophenyl)indoline (1a) in high yield. The nitro group was reduced catalytically and the resulting amino function was acylated to afford the heterocycle percursor amide 3. Refluxing this amide in phosphorus oxychloride brought about a Bischler‐Napieralski type cyclodehydration to form the target 1,2‐dihydroindolo[1,7‐ab][1,5]benzodiazepine ring system. Dehydrogenation of the latter led to the fully aromatic indolo[1,7‐ab][1,5]benzodiazepine structure 5, while reduction with sodium borohydride provided the 1,2,6,7‐tetrahydroindolo[1,7‐ab]‐[1,5]benz

ISSN:0022-152X    

DOI:10.1002/jhet.5570160508

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractA series of nitroimidazoles were subjected to hydroxymethylations under a variety of conditions. Hydroxymethylation of 1‐(2‐hydroxyethyl), 1‐(2‐acetoxyethyl), and 1‐(2‐chloroethyl) substituted 5‐nitroimidazoles with paraformaldehyde in dimethyl sulfoxide yielded the respective 2‐hydroxymethyl analogs (5–7). However, attempts to hydroxymethylate 1‐(2‐hydroxyethyl), 1‐(2‐acetoxyethyl), 1‐(2‐cyanoethyl) substituted 4‐nitroimidazoles and 1‐(2‐hydroxyethyl)‐2‐nitroimidazole were unsuccessful. Treatment of 1‐(2‐acetoxyethyl)‐5‐nitro‐2‐imidazolecar‐baldehyde(10) with hydroxylamine‐O‐sulfonic acid afforded a mixture of corresponding 2‐carbonitrile (12) and 2‐(N‐hydroxy)carboximidamide (13). Hydrolysis of 10 with ethanolic hydrochloric acid yielded 8‐ethoxy‐5,6‐dihydro‐3‐nitro‐8H‐imidazo[2,1‐c] [1,4]oxazine (11) which, on subsequent reaction with hydroxylamine‐O‐sulfonic acid, afforded 1‐(2‐hydroxyethyl)‐5‐nitroimidazole‐2‐(N‐hydroxy)carboximidamide (15). Reaction of 4(5)‐nitroimidazole with chloropropionitrile produced a mixture of the isomeric 1‐(2‐cyanoethyl) substituted 4‐ and 5‐nitroimidazoles. Treatment of 2,4(5)‐dinitroímidazole with chloropropionitrile afforded a mixture of 4(5)‐chloro‐5(4)‐nitroimidazole and 1‐(2‐cyanoethyl)‐4‐nitro‐5‐chloroimidazoIe. Reaction of n

ISSN:0022-152X    

DOI:10.1002/jhet.5570160509

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractIodide‐catalyzed ring expansion of 2‐[(1‐aziridinylcarbonyl)amino]benzoic acid methyl ester (2) gave 2,3‐dihydro‐5H‐oxazolo[2,3‐b]quinazolin‐5‐one (3) in quantitative yield. Treatment of the dimethyl analog of 2 (9) with sodium iodide in acetone gave a mixture of the 2,3‐dihydro‐2,2‐dimethyl‐ (10) and 2,3‐dihydro‐3,3‐dimethyl‐5H‐oxazolo[2,3‐b]quinazolin‐5‐ones (11). However, rearrangement of 9 with sulfuric acid produced only 10. Synthesis of 11 by another route for comparison is described, and the known syntheses of 2,3‐dihydro‐5H

ISSN:0022-152X    

DOI:10.1002/jhet.5570160510

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY