摘要:

AbstractThe synthesis of potential platelet aggregation inhibitors 4,6,7,8‐tetrahydroimidazo[1,2‐a]pyrazolo[3,4‐d]‐pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones derivatives is described starting from 4,6‐dichlorop

ISSN:0022-152X    

DOI:10.1002/jhet.5570270401

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

Abstract3‐Alkylthio‐ (or 3‐arylthio‐)pyridines and 3,5‐bis(alkylthio)pyridine can be conveniently prepared by the reaction of 3‐thiocyanato‐ or 3,5‐bis(thiocyanato)pyridines with tri‐n‐butylphosphine in the

ISSN:0022-152X    

DOI:10.1002/jhet.5570270402

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

Abstract6‐Cyanomethylene (2), which was preparedvia1by substitution with malononitrile, has been catalytically hydrogenated to the α‐(aminomethylene)‐9‐(methoxymethyl)‐9H‐purine‐6‐acetonitrile (3) in good yield usingN,N‐dimethylformamide‐benzene as solvent over Pd‐C under medium pressure. Intermediate3was derived to aldehyde5by hydrolysis with acid or base. Substitution of3with amines gave the corresponding alkylamines6and7. Reaction of3with hydrazine and acetamidine hydrochloride gave pyrazole derivative8and pyrimidine der

ISSN:0022-152X    

DOI:10.1002/jhet.5570270403

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractThe syntheses of 6‐fluoro‐7‐piperazin‐1‐yl‐9‐cyclopropyl (or 9‐p‐fluorophenyl)‐2,3,4,9‐tetrahydroisothiazolo[5,4‐b]quinoline‐3,4‐diones as well as novel synthesis of isothiazolo‐3(2H)‐one system are described. Key steps include the regiospecific displacement of a sulfinyl group and the amination of the resultant mercapto derivative followed by an intramolecular nucleophilic displacement cyclization reaction to generate the novel 2,3,4,9‐tetrahydroisothiazolo[

ISSN:0022-152X    

DOI:10.1002/jhet.5570270404

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractA new strategy for the synthesis of 6‐hydroxyalkyl‐ and 6‐hydroxyaralkyl‐6H‐dibenz[c,e][1,2]oxaphosphorin 6‐oxides3was achieved by the reaction of 2‐(2‐hydroxyphenyl)phenylphosphonic acid (1) with various carbonyl compounds2. The desired products3were obtained in ac

ISSN:0022-152X    

DOI:10.1002/jhet.5570270405

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

Abstract5,7‐Diamino[1,3,4]thiadiazolo[3,2‐a]pyrirnidinium chloride2, 7‐amino[1,2,4]triazolo[1,5‐c]pyrimidine‐5(6H)‐thiones3and the 5(6H)‐one derivative4awere synthesized by the reaction of 1,4,6‐triaminopyrimidine‐2(1H)‐thione1with phosphoryl chloride andN,N‐dimethylacylamides. Further, compounds4were prepared from2, 3or 1,4,6‐triaminopyrimidin‐2(1H)‐one6by the treatment with the above reagents. Compounds3and4were converted to 7‐amino[1,2,4]triazol

ISSN:0022-152X    

DOI:10.1002/jhet.5570270406

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractReactions of dimethyl acetylenedicarboxylate with 3‐methylindole and 2,3‐dimethylindole under boron trifluoride‐diethyl ether catalysis were carried out at low temperature (0–25°). Thermally unstable cyclobutenes were isolated, mainly in apolar solvents, which isomerized to benzazepines. The other compounds isolated were Michael adducts and dihydro‐2‐o

ISSN:0022-152X    

DOI:10.1002/jhet.5570270407

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractThe photochemical behaviour of 3‐styryl‐5‐phenyl‐(5‐methyl)‐1,2,4‐oxadiazoles in methanol at 254 nm has been investigated. A photoinduced rearrangement to the quinoline system has been pointed out and explained as proceeding through an initial photolysis of the ring ON bond, followed by a six membered ring closure reaction involving th

ISSN:0022-152X    

DOI:10.1002/jhet.5570270408

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractIt has been established that the primary reactions products between dehydroacetic acid andp‐chlorophenylhydrazine or 4‐phenylthiazol‐2‐ylhydrazine are 4‐acetylacetyl‐5‐hydroxypyrazoles. These compounds react with the above hydrazines to yield 4‐(pyrazol‐5′‐yl)‐2‐pyrazolin‐5‐ones which exist in s

ISSN:0022-152X    

DOI:10.1002/jhet.5570270409

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractCompounds of the novel 7,10a‐methanocycloocta[c,d]indazole ring‐system5, 7are obtained by the action of hydrazines on 1‐chloro(or hydroxy)diisophor‐2,7‐en‐3‐ones1–3. Their formulation agrees with their origin and their chemical and spectral characteristics. Analogous syntheses of two comparable ring‐systems include the production of a substituted 7,10a‐methanocycloocta[g,h][2,1]benzisoxazole10by a facile cyclodehydration of the oxime of diisophorone9a, and that of the indole‐analogue13by the action of aniline on diisophoron

ISSN:0022-152X    

DOI:10.1002/jhet.5570270410

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY