摘要:

AbstractThe synthesis of a novel class of annelated 1,4‐benzodiazepinen, the 2‐R‐3 methyl‐5,6‐dihydro‐7H‐pyrrolo[1,2‐d][1,4]benzodiazepin‐6‐ones (Ve‐e), is described. The reaction of 2‐(o‐aminophenyl)‐3‐R‐5‐methylpyrroles(IIIa,b) with bromoacetyl bromide in the presence of triethylamine produced the title compounds. An alternative synthetic route was achieved by means of the reactions of 1a,b with the appropriated α‐aminoacids. The catalytic reduction of IVe‐e over 10% palladium on charcoal led in good to excellent yields directly to the formation of pyrr

ISSN:0022-152X    

DOI:10.1002/jhet.5570160201

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractSeveral amide oximes underwent condensation reactions with dimethyl acetylene dicarboxylate to afford 1:1 adducts. Under basic conditions, these adducts underwent ring closure to afford several methyl [3‐(substituted)‐4,5‐dihydro‐5‐oxo‐6H‐1,2,4‐oxadiazin‐6‐ylidene]acetates. The reactions of these compounds with a variety of amines resulted in addition‐rearrangement reactions with the formation of the corresponding methyl 2‐substituted‐5‐substituted amino‐1,6‐dihydro

ISSN:0022-152X    

DOI:10.1002/jhet.5570160202

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe title compounds were obtained by cycloaddition of sulfene toN,N‐disubstituted 3‐amino‐1‐phenyl‐2‐propen‐1‐ones and to 2‐metbylphenylaminomethylenecycloalkanones, respectively. Steric and electronic aspects of these reactions, as well as the failure of cycloaddition in the case ofN,N‐disubstituted 4‐arnino‐3‐buten

ISSN:0022-152X    

DOI:10.1002/jhet.5570160203

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractO‐alkylations of indoxylie acid (2b) to produce 3‐indolyl‐alkyl ethers and a synthesis of 5‐melhoxy‐2‐earboxyindol‐3‐oxyaeetic acid (25

ISSN:0022-152X    

DOI:10.1002/jhet.5570160204

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe ultraviolet absorption, fluorescence, and infrared absorption spectra of fifteen 3‐benz‐amidophthalimides are described. In general, the nature or position of the substituents on the benzamide moiety has little effect on the ultraviolet absorption and fluorescence spectra of these, compounds. The absorption baud at 271 nm is more sensitive to substituent variations than the other two bands (at 227 nm and 341 nm), indicating this band is a composite of bands observed in the spectra of 3‐aminophthalimide and the substituted benzamide. The fluorescence of 3‐amino‐phthalirnide and the 3‐benzamidophthalimides is due to the same transitions. The infrared absorption wavenumbers for the amide and imide vibrations of the 3‐benzamidophthalimides are

ISSN:0022-152X    

DOI:10.1002/jhet.5570160205

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe attempted oxidative demethylation of a series of o‐dihydroxybenzo[b]thiophene methyl ethers with cerium (IV), argentic oxide, periodale and thallate usually led to intractable mixtures. However, in one ease, use of ceric ammonium nitrate resulted in nitration of the benzo[b]‐thiophene ring. In another example, treatment with aqueous periodate or thallate resulted in oxidative hydroxylation of benzo[b]thioph

ISSN:0022-152X    

DOI:10.1002/jhet.5570160206

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe Meldrum's acid adduct of isobutyrophenone was cyclized directly and in high yield to the title compound, which could then be alkylated at the 2‐position with methyl iodide or ethyl 6‐bromohexanoate. In the latter case, acid hydrolysis of the resultant ester gave the analogous acid, but alkaline hydrolysis resulted in ring opening of the indanone portion of the molec

ISSN:0022-152X    

DOI:10.1002/jhet.5570160207

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractAn approach to the synthesis of the benzo[f]quinazoline ring system using a preformed pyrimidine is described. A facile cyclization of a ketone function into the 5‐position of uracil is the key step in this sequenc

ISSN:0022-152X    

DOI:10.1002/jhet.5570160208

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe title compounds are. Prepared by the reaction of carbonyl compounds with 1‐(2′‐amino‐methylphenyl)pyrrole hydroc

ISSN:0022-152X    

DOI:10.1002/jhet.5570160209

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY

摘要:

AbstractThe reaction of 4,7‐diehlorofuro[2,3‐d]pyridazine (1) with potassium cyanide in DMSO gave two products, (E)‐3,6‐diehloro‐5‐(2‐cyanovinyl)‐4‐hydroxypyridazine (II) and 5,8‐dichloro‐2‐oxo‐2H‐pyrano[2,3‐d]pyridazine (III) as a result of ring opening or ring expansion. A new ring system, 2‐oxo‐2H‐pyrano[2,3‐c]pyridazines (IX, XII, XIII) was obtained from 5,8‐dichloro‐3‐m

ISSN:0022-152X    

DOI:10.1002/jhet.5570160210

出版商:Wiley‐Blackwell    

年代:1979

数据来源: WILEY