摘要:

AbstractThe use of α‐(substituted‐phenyl)‐4‐morpholineacetonitriles in 1,4‐additions to ethyl acrylate, ethyl crotonate, methyl α‐methylacrylate, acrylonitrile, methylacrylonitrile, crotononitrile and cinnamonitrile was studied. A convenient route to 6‐aryl‐4,5‐dihydro‐3(2H) pyridazinones from aryl aldehydes and heterocyclic al

ISSN:0022-152X    

DOI:10.1002/jhet.5570150601

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractThe reaction rates of the conversion of various substituted picolinic and quinaldinic acids to the corresponding trichloromethylpyridines and quinolines by treatment with phosphorus pentachloride in refluxing thionyl chloride have been measured, and the apparent second‐order kinetic constants determined. The logarithmic rate constants (log k) were found to be linear with the basicities (pKa) of the unsaturated ring nitrogens in the substrates. The reaction constant, p, of the conversion was estimate

ISSN:0022-152X    

DOI:10.1002/jhet.5570150632

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractLes cinétiques d'hydrolyse basique de deux Δ2imidazolines ont été suivies par spectrométrie uv dans la soude et dans le tampon carbonate. Dans les milieux les plus basiques le fait que la vitesse d'hydrolyse soit indépendante dupH est expliqué si l'étape déterminante est l'attaque de l'ion hydroxyle sur la forme protonée du substrat. Dans les milieux moins basiques, un changement d'étape lente intervient, la rupture de l'intermédiaire d'addition de l'ion hydroxyle sur le substrat protoné devenant

ISSN:0022-152X    

DOI:10.1002/jhet.5570150602

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractBased on the data from1H nmr spectra, the structure and spatial configuration of the ahove mentioned hydantoins are established. In the 3‐alkyl‐3‐azabicyelo[3.3.f ]nonane‐9‐spiro‐5′‐hydantoins analyzed, we confirm the chair‐chair configuration and the presence of only one stereoisomer at the spiro carbon atom (with the C4′=() group axial with regard to the piperidine ring). In the 3,7‐dialkyl‐3,7‐diazabieyclo[3.3.1 ]nonane‐9‐spiro‐5′‐hydantoins analyzed, we also confirm the chair‐chair configuration and we calculate the percentage of

ISSN:0022-152X    

DOI:10.1002/jhet.5570150603

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractVarious quinol‐4‐yl hydrazones on heating in high boiling solvents undergo cyclizations to give lH‐pyrrolo[3,2‐c]quinolines in good yields. Some of these pyrroloquinolines were alkylated to provide theirN‐alkyl de

ISSN:0022-152X    

DOI:10.1002/jhet.5570150604

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractSynthetic routes are described tor the preparation of internal standards for analytical determinations of the antiepileptic agent primidone (1) and one of its primaryin vivometabolites, phenylethylmalonamide (PEMA, 3). The internal standards synthesized in the present study arep‐methylprimidone (9) andp‐methylPEMA (8). The internal standards differ in structure from the parent drug and metabolite in that the phenyl substituents of the drug and metabolite have been replaced byp‐tolyl substituents. The synthetic route for the preparation ofp‐methylPEMA (8) entailed conversion of an appropriately substituted malonate to a 4,4‐disubstituted pyrazoli‐dine‐3,5‐dione, and Raney nickel reduction of the latter substance to a malonamide. This same sequence of reactions was useful for the preparation of PEMA (3) itself. A fusion ofp‐methylPEMA (8) with formic acid and formamidine acetate resulted in the formation ofp‐m

ISSN:0022-152X    

DOI:10.1002/jhet.5570150605

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractBy application of the Friedlander synthesis on 2,3‐dihydro‐l‐benzothiepin‐4(5H) one (4), the corresponding [4,5‐b]quinoline derivatives5aand5bwere obtained. Starting from the ketone (4) and by application of the Fischer indole synthesis, 1‐benzolhiepino[4,5‐b]indole (6) and 1‐benzothiepino[4,5‐b]benzo[g]indole (7) were obtained. When β‐naphthylhydrazine was used in the indolisation reaction, a mixture of 1‐benzothiepino[4,5‐b]benzo[e]indole (8) and 1‐benzothiepino[4,3‐b]benz

ISSN:0022-152X    

DOI:10.1002/jhet.5570150606

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractCe travail décrit une approche générale de synthèse permettant de parvenir aux D‐ribo‐furanosyl‐1‐purines anomères par cyclisation de précurseurs imidazoliques correspondents. En particulier, les dérivés oxo‐6 et mercapto‐6 ont été décrits et leur structure confirmée par les méthodes physico‐ch

ISSN:0022-152X    

DOI:10.1002/jhet.5570150607

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractL'action d'un β‐cetoéster tel Fàcétylacétate d'éthyle sur les diamino‐1,5 imidazoles conduit a deux types de réactions concurrentes et permet de synthétiser des imidazo[1,5‐b]triazépinones et des imidazo[4,5‐b]pyridinones. Les produits obtenus ont une structure lactamique qui correspond à l'action de la fonction ester sur le groupe amino non hydrazinique du diamino‐imidazole. Un nouveau type de transposition des imidazotriazépinones en imidazopyridinones a été mis en évidence, il résulte de la réactivité particulière de la double liaison C

ISSN:0022-152X    

DOI:10.1002/jhet.5570150608

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY

摘要:

AbstractAn infrared investigation cmN‐methyl‐1,3‐thiazolidine‐2‐thione and ‐2‐selone in the range 4000‐200 cm−1is reported. ThevCSandv CSevibrations give contributions to the absorptions around 1000 cm−1and below 600 cm−1. The assignments are supported by comparison of their ir spectra with those ofS‐ andSe‐methiodides. The π‐bond orders of the thio‐ and seleno‐ketonic links in these compounds are higher than those found for 1,3‐im

ISSN:0022-152X    

DOI:10.1002/jhet.5570150609

出版商:Wiley‐Blackwell    

年代:1978

数据来源: WILEY