摘要:

AbstractAn important process for the acid catalyzed cleavage of the benzoyl group from 3‐benzoylindoles in high yield is identified and its application for the facile syntheses of 2‐substituted indoles is demonstrated by preparing some 2‐(2‐arylethyl)‐ and 2‐(aminomethyl)indoles from 1,3‐dibenzoyl‐2‐brom

ISSN:0022-152X    

DOI:10.1002/jhet.5570290601

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractA series of enaminones derived from 2,4‐dioxocyclohexane carboxylic acid esters has been prepared. The use of some of the new derivatives in the synthesis of some quinazolones and imidazoloquinazolines is illustrate

ISSN:0022-152X    

DOI:10.1002/jhet.5570290602

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe preparation of tetrahydrobenzophenanthridinones4and5, potential useful intermediates for the synthesis of Dynemicin A models, is described. The structure of all products was corroborated by ir,1H‐nmr, ms and X‐ray spectrosc

ISSN:0022-152X    

DOI:10.1002/jhet.5570290603

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractSeventeen new substituted 14‐crown‐4 derivatives3‐10, 35‐40, 42, 45and46are described. A series of nine compounds2‐10with two, three or four substituents in the 6‐ and/or 13‐positions was synthesized in good yields from the appropriate diols and ditosylates using improved cyclization conditions. The solid state structures of 6,6,13,13‐tetra(benzyloxymethyl)‐14‐crown‐4 (8) and lithium thiocyanate complexes oftrans‐ andcis‐6,13‐bis(spiro‐2,2‐dichlorocyclopropyl)‐14‐crown‐4 (45) and (46

ISSN:0022-152X    

DOI:10.1002/jhet.5570290604

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractN‐Phenylpyrrole and pyrazole nitriles3,4,10were prepared in one step from the corresponding aldehydes. The nitriles were converted into novel amidines5,6,14and related diamines7,8,12were also prepared from the aldehydes. The orientation of the phenyl ring to the basic function was controlled by modifying the torsional angle between the rings by methyl group substitution on the heterocycl

ISSN:0022-152X    

DOI:10.1002/jhet.5570290605

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractA reinvestigation of a synthetic route to 5′‐O‐trityl‐protectederythro‐CNT that incorporates a modification of the Stork radical cyclization‐cyanation reaction generates an unexpectedt

ISSN:0022-152X    

DOI:10.1002/jhet.5570290606

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe synthesis of some [6:6]‐ or [6:5]‐fused bicyclic pyridazin‐6‐one nucleosides, starting from 4,5‐dichloro‐3‐nitro(or amino) and 3‐hydrazinopyridazin‐6‐one nucle

ISSN:0022-152X    

DOI:10.1002/jhet.5570290607

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe title compound, a mixture of two isomers differing in the position of a methoxy substituent in one benzene ring, was obtained in a Ni‐templated synthesis directly as a water soluble dihydrochloride of the free base. The cyclic voltametry study indicated that in a neutral solution the reduction and oxidation are irreversible one electron processes, the latter leading to cation radical undergoing polymerization, a process followed by deposition of a film on the electrode. In 1,2‐dichloroethane the cation radical is oxidized to a dication, both species being much less stable than those originating frommeso‐tetraphenylporphyrin. The title compoud at 2.5 × 10−5Min Tris buffer showed a 50% inhibition of the growth of malignant melanoma cells as compared to a 44% inhibition shown by a water solublemeso‐monomethoxy‐tris(N‐methylpyridinium)porphyrin. The exposure to light for 30 minutes at 2.5 times smaller concentration increased the inhibition caused by the pseudo‐porphyri

ISSN:0022-152X    

DOI:10.1002/jhet.5570290608

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe reaction of asymmetrically substituted β‐diketones with hydroxylamine to give 3,5‐diarylisoxazoles has been re‐investigated, and has been found to occur with a low degree of site‐selectivity unless steric effects are operating. The isoxazole that has the more electron‐deficient aryl group in position 3 is formed preferentially when the reactions are run with hydroxylamine hydrochloride. When the reactions are performed in a neutral medium, a reversed site‐selectivity is observed. Steric effects have a much stronger influence on the selectivity of the reaction: when a substituent is present in theorthoposition(s) of the phenyl ring, the heterocycle bearing theortho‐substituted phenyl group in position 5 is obtained as the sole product both in acidic and in

ISSN:0022-152X    

DOI:10.1002/jhet.5570290609

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractSeven new per(N‐formyl)polyaza‐crown macrocycles 1‐7 containing 14 to 21 ring members have been synthesized in yields of over 40%viathe cyclization reaction of the appropriate per(N‐formyl)polyamine11‐13with the appropriate ditosylate, dibromide or diiodide. Three of the per(N‐formyl) macrocycles5‐7were hydrolyzed under acidic conditions to give the unsubstituted polyaza macrocycles8‐10in yie

ISSN:0022-152X    

DOI:10.1002/jhet.5570290610

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY