摘要:

AbstractDerivatives of the 5H‐thiazolo[3,2‐b]‐ and 2H‐thiazolo[2,3‐c]‐as‐triazine systems were synthesizedviacondensation of tetrahydro‐I‐methyl‐as‐triazine‐3(2H)‐thione with ethylene dibromide and ethyl bromoacetate, respectively. An hypothesis is given for the formation of the [3,2‐b] system in one of these reactions and the [2,3‐c] system in the other. Structure proof was accomplished by an unequivocal synthesis of o

ISSN:0022-152X    

DOI:10.1002/jhet.5570070601

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractSeveralN‐(2,4‐dinitrophenyl)nitroazoles which cannot be obtained by direct nitration ofN‐phenylazoles have been prepared by condensation of 2,4‐dinitrofluorobenzene with the appropriate nitroazoles. The structures of the products are assigned on the basis of their proton magnetic resonance spectra; in all the examples studied, condensations occur at positions remote from the nitro group of the nit

ISSN:0022-152X    

DOI:10.1002/jhet.5570070602

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractCyclization of 4‐(1‐methylindol‐3‐yl)‐2‐butanone and the corresponding 1‐benzyl analog in trifluoroacetic acid furnishes 9‐methyl‐ and 9‐benzyl‐3,4,4a,9a‐tetrahydro‐2(1H)‐carbazolone, respectively. Under the same conditions, 4‐(indol‐3‐yl)‐2‐butanone gives the dimer, 3‐(3‐oxo‐butyl)‐2‐[3‐(3‐oxobutyl)‐2‐indolinyl]indole. When boron trifluoride etherate is used instead of trifluoroacetic acid, the desired 3,4,4a,9a‐tetrahydro‐2(1H)‐carbazolone is obtained. The determination of the structure of the tetrahydrocarbazolones is desc

ISSN:0022-152X    

DOI:10.1002/jhet.5570070603

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractDimethyl‐N‐carbethoxyazepines, isolated from the reaction between ethyl azidoformate ando‐,m‐ andp‐xylenes, react with tetracyanoethylene to give [4 + 2] Diels‐Alder adducts. Nitroso‐benzene is inert toward 2‐methylazepines, but reacts with 3,6‐dimethyl‐N‐carbethoxyazepine to give a [6 + 2] cycloadduct. The effect of two methyl substituents on the course of the cycloaddition r

ISSN:0022-152X    

DOI:10.1002/jhet.5570070604

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractThe syntheses and reactions of various thieno[2,3‐c]‐ and thieno[3,2‐c] pyridines are described. Molecular orbital calculations were performed on thieno[2,3‐c]pyridine (1) in order to determine the most susceptible sites to electrophilic and nucleophilic attack. Superdelocalizability values, Sr‐ are reported for each position in this molecule to give relative orders of reactivity towards the two types of reactions. Electrophilic attack was found to occur experimentally at C‐3 in all the thienopyridines studied. Peracid oxidation of thieno[2,3‐c]‐ and thieno[3,2‐c]pyridines produced only theN‐oxide. The lack of reactivity of certain thienopyridines under Vilsmeier formylation and Friedel‐Crafts acetylation conditions was related to their basicities. The dissociation constants of various thienopyridini

ISSN:0022-152X    

DOI:10.1002/jhet.5570070605

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of a series ofN‐glycosyl‐v‐triazoles has been accomplished by the 1,3‐dipolar cycloaddition of several glycosyl azides to methyl propiolate and propiolic acid. In most of the cases the two isomeric v‐triazoles were obtained. Structural and anomeric configuration assignments for theN‐glycosides obtained were made on the basis of NMR data. None of the compounds possessed appreciable biological activity against HeLa cells in culture and mouse

ISSN:0022-152X    

DOI:10.1002/jhet.5570070606

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractA convenient synthesis of alkyl substituted 2‐pyrazolines (III) has been developed from the reaction of acids with hydrazones (I) and azines (IV). An alkylidenebis‐1‐methyl‐2‐alkylidene‐hydrazine (V) was isolated as an intermediate, in the preparation of 5‐isopropyl‐1,4,4‐ trimethyl‐2‐pyrazoline (IIId), and protonated vinylhydrazones (II) are proposed as common intermediates in the formation of III, IV and V. The 4,5‐dialkyl‐2‐pyrazolines (IIIk‐m) that were prepared were shown to be free of isomers by nmr. The thermal isomerization of IIIk‐m to 3,4‐dialkyl‐2‐pyrazolines (IIIn‐o) was found to be incomplete at the temperatures studied. The reaction of IIIn‐o with acetone afforded 3,4‐dialkyl‐1‐[2‐(2‐methyl‐4‐oxopentyl)]‐2‐pyrazolines (I

ISSN:0022-152X    

DOI:10.1002/jhet.5570070607

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractReaction of one or two molecules of aziridine with the cyano groups of trichloroacetonitrile and trifluoroacetonitrile was observed. The resulting aziridinyl amino derivatives represent novel functional groups. Intramolecular cyclization of a bis‐aziridinyl structure involving one aziridinyl group was observed. New synthetic routes to imidazolines and imidazolidines are a result of these rearrangment

ISSN:0022-152X    

DOI:10.1002/jhet.5570070608

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

Abstract5‐Butoxyhydantoin (2a), 3‐benzyl‐5‐methoxyhydantoin (2b) and 3‐p‐chlorophenyl‐5‐methoxy hydantoin (2c) were found to react, in the presence of an acid catalyst, with aromatic compounds and olefins to give 5‐arylhydantoin (3) and 5‐alkylhydantoins with an unsaturated side chain. Isomers which differ in the location of the double bond (4,5,6) as well ascis‐transisomers were isola

ISSN:0022-152X    

DOI:10.1002/jhet.5570070609

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of imidazo [1,2‐c] quinazoline was effected by manganese dioxide oxidation of the 5,6‐dihydroimidazo [1,2‐c] quinazoline which was prepared by treatment of 2‐(o‐nitro‐phenyl)‐1‐hydroxyimidazole‐3‐oxide with zinc powder and formic acid. The synthesis of some methyl derivatives of this ring system are also described. Structural assignments for all of the products were made

ISSN:0022-152X    

DOI:10.1002/jhet.5570070610

出版商:Wiley‐Blackwell    

年代:1970

数据来源: WILEY