摘要:

AbstractThis review described developments in the synthesis of heterocyclic compounds using carbon disulfide and their products.

ISSN:0022-152X    

DOI:10.1002/jhet.5570260501

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractNew derivatives of dehydroacetic acid and triacetic acid lactone functionalized at both C‐5 and at the methyl group at C‐6 have been synthesized as intermediates for the preparation of thromboxane B2analogues. 6‐Mercaptomethyl‐4‐methoxy‐2‐pyrone and some derived thioethers have been also prepared. New thioether derivatives ofO‐alkyloximes of dehydroacetic acid have been synthesized and tested for herb

ISSN:0022-152X    

DOI:10.1002/jhet.5570260502

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractThe synthesis of naphthylethylcarbazole derivatives is described.

ISSN:0022-152X    

DOI:10.1002/jhet.5570260503

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractCyclization ofN, N′‐dialkyl‐N‐(3‐methyluracil‐6‐yl)‐N′‐(5‐nitro‐3‐methyluracil‐6‐yl)‐p‐phenylenediamines with the Vilsmeier reagent gives the corresponding 1,3,6,8,10,11,14‐heptaazapentaphene‐2,4,7,9‐(14H,3H,8H,‐11H) ‐tetrones (angular mixed flavins) 2. Cyclization ofN, N′‐di(5‐nitro‐3‐methyluracil‐6‐yl)‐p‐phenylenedi‐amines with the Vilsmeier reagent gives the corresponding 1,3,5,6,8,10,11,14‐octaazapentaphene‐2,4,7,9‐(14H,3H,8H,11H)‐tetro

ISSN:0022-152X    

DOI:10.1002/jhet.5570260504

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractThe unexpected formation of 11H‐pyrido[2,1‐b]quinazolin‐11‐one derivative 6 from 5,11‐dihydro‐6H‐pyrido[2,3‐b]‐1,4‐benzodiazepin‐6‐one (2) has been observed. Its structure 6 was determined by X‐ray crystallography. Detailed nmr study provided a complete set of proton and carbon‐13 nmr parameter

ISSN:0022-152X    

DOI:10.1002/jhet.5570260505

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractCondensation of 2‐amino‐4‐hydroxy‐2‐mercaptopyrimidine (2) hydrate and ethyl 4‐bromocrotonate gave a mixture of ethyl 7‐amino‐2,3‐dihydro‐5‐oxo‐5H‐thiazolo[3,2‐a]pyrimidine‐3‐acetate (4) and 2a,3‐dihydro‐1‐thia‐5,8,8b‐triazaacenaphthylene‐4,7(2H)‐dione (5) whereas reaction of 2 with 4‐bromocrotononitrile afforded only 7‐amino‐2,3‐dihydro‐5‐oxo‐5H‐thiazolo[3,2‐a] pyrimidine‐3‐acetonitrile. Reaction of the tricycle 5 (which was isolated as a hemihydrate) with excess methyl iodide/potassium carbonate in dimethylformamide resulted in both ring hydrolysis and methylation to give 3,4‐dihydro‐1,7‐dimethyl‐4‐ [(methylthio)methyl]‐2H‐pyrimido[1,6‐a]pyrimidine‐2,6,8(1H,7H)‐trione (10). Methylating 5 with excess methyl iodide/sodium methoxide in methanol also resulted in ring fragmentation and methylation but instead afforded methyl 7‐methyl‐amino‐2,3‐dihydro‐5‐o

ISSN:0022-152X    

DOI:10.1002/jhet.5570260506

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractFriedel‐Crafts reaction of triphenyleno[1,12‐bcd]thiophene (2) by means of aluminum chloride, nitrobenzene, and a limited excess of acetyl chloride yielded 3‐acetyl‐2 (78%) and 3,5‐diacetyl‐2 (7%). Use of a large excess of acetyl chloride gave yields of 42% and 22%, respectively. Wolff‐Kishner reduction of the acetyl compounds produced 3‐ethyl‐2 (15%) and 3,5‐diethyl‐2 (8%). Structures were assigned largely on the basis of1H nmr and ultraviolet absorption sp

ISSN:0022-152X    

DOI:10.1002/jhet.5570260507

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractThe reaction of 2‐benzothiazolinone, 2‐benzoxazolinone or benzothiazoline‐2‐thione under basic conditions with various electrophiles afforded the titled compounds1‐13, 29‐31and40‐48.The 3‐(substituted‐aminomethyl)‐2‐benzothiazolinone and related compounds14‐25were prepared by the reaction of 3‐(hydroxymethyl)‐2‐benzothiazolinone or the appropriate 2‐benzothiazolinone and formaldehyde with the appropriate amine or substituted aniline. The reaction of9, 13or25with methyl iodide afforded the quaternary ammonium iodides26‐28.The reaction of the appropriate potassium salts of various phenol with 3‐(chloromethyl)‐2‐benzothiazolinone afforded the 3‐(substituted‐phenoxymethyl)‐2‐benzothiazolinone and related compounds32‐39.The ethyl or isopropylxanthates49‐54were synthesized by the reaction of 3‐(chloromethyl)‐2‐benzo‐thiazolinone and appropriate compounds with potassium ethyl or isopropyl xanthate. The reaction of 3‐(chloromethyl)‐

ISSN:0022-152X    

DOI:10.1002/jhet.5570260508

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractVarious 8‐hydroxy‐5‐deazaflavin derivatives were synthesized as the model compounds of coenzyme F420‐These compounds oxidized benzylamine to benzaldehyde more efficiently than the corresponding 8‐unsubstituted 5‐d

ISSN:0022-152X    

DOI:10.1002/jhet.5570260509

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractGanciclovir 2 and 2′‐carba‐ganciclovir5aare anti‐viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy and fluoro derivatives of 2′‐carba‐ganciclovir were prepared to examine the effect of re‐introducing a binding site close to that in the original oxa side chain. The cyclic phosphate of carba‐ganciclovir

ISSN:0022-152X    

DOI:10.1002/jhet.5570260510

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY