摘要:

Abstract9‐Chloro‐2‐dimethylaminomethyl‐1,2‐dihydropyrrolo[3,2,1‐kl]phenothiazine (3b), a conformationally restricted analog of chlorpromazine, has been synthesised and has been found to be devoid of neurolept

ISSN:0022-152X    

DOI:10.1002/jhet.5570180501

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe reaction of 2‐(dialkylamino)‐7‐methoxychromones with malononitrile in the presence of acetic anhydride afforded [2‐(dialkylamino)‐7‐methoxy‐4H‐chromen‐4‐ylidene]malononitriles. When these compounds were refluxed with concentrated hydrochloric (or hydroiodic) acid, 2‐(dialkylamino)‐7‐methoxy(or hydroxy)‐4‐methylchromenylium salts were obtained. The use of concentrated sulfuric acid or polyphosphoric acid in the hydrolysis was also investigated. The preparation of ethyl [2‐(dialkylamino)‐7‐methoxy‐4H‐chromen‐4‐ylidene]cyanoacetates and their behavior when treated with acids are also described, as well as the synthesis of some 3‐(dialk

ISSN:0022-152X    

DOI:10.1002/jhet.5570180502

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe synthesis ofN‐[(α‐acetoxy)‐4‐pyridylmethyl]‐3,5‐dimethylbenzamide (4) and its reactivity are described. Since the acetoxy is a good leaving group, 4 gives SNproc

ISSN:0022-152X    

DOI:10.1002/jhet.5570180503

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

Abstract3‐Hydroxyphenalenone reacts witho‐disubstituted benzenes (substituents: NH2, OH, CH2OH and SH), aliphatic and aromatic aldehydes to give the various heterocyclic compounds which are fused with phenalene ring. These reactions resemble those of 1,3‐cyclohexanediones in many res

ISSN:0022-152X    

DOI:10.1002/jhet.5570180504

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe reaction of mercaptoacetic acid with nitriles was investigated. Whereas 4‐hydroxythiazole derivative could be obtained from the reaction of benzoylacetonitrile and of ethyl cyanoacetate with mercaptoacetic acid, a bithiazole derivative was obtained on treatment of benzonitrile with the same reagent. The behaviour of the synthesised thiazole derivatives towards aromatic aldehydes and hydrazines is reporte

ISSN:0022-152X    

DOI:10.1002/jhet.5570180505

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractThe crystal structure of a mesoionic pyrimidine was determined by means of an X‐ray structure analysis. The structure is discussed in terms of Dähne's concept as consisting of two coupled polymethin

ISSN:0022-152X    

DOI:10.1002/jhet.5570180506

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA reaction sequence involving halogenation and replacement of the halo substituent by a nitro group using dinitrogen tetraoxide has led to a general, convenient route to 5‐nitrooxazoles. Reaction schemes employing both bromine and iodine as the halo substituent have been investigated; however, the method using iodine preceded by a mercuration step affords a better overall yield in the range of 20–50%. Both 2‐ and 4‐nitro‐oxazoles can be prepared by this latter sequence, though in lower overall yield

ISSN:0022-152X    

DOI:10.1002/jhet.5570180507

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA synthesis of four 1H‐[1,2]diazepino[4,5‐b]indole derivatives and some preliminary information about their biological activity are presented. The starting materials were 2‐ethoxycarbonylindoles and 2‐ethoxy‐carbonyl‐3‐formylindoles, la, b and 2a, b, respectively. 2‐Ethoxycarbonyls la, b reacted with 1‐dimethylamino‐2‐nitroethylene and ‐2‐ethoxycarbonyl‐3‐formylindoles 2a, b in the presence of nitroalkanes (nitromethane or nitroethane) giving 3‐(2‐nitrovinyl)indoles 3a, b. Reduction of 3a, b yielded β‐(2‐oxoalkyl)indoles 4. On reaction with an excess of hydrazine hydrate, compounds 4 gave satisfactory yields of 5

ISSN:0022-152X    

DOI:10.1002/jhet.5570180508

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractA one step synthesis ofs‐triazolo[4,3‐b]pyridazine using 3‐chloro‐6‐hydrazinopyridazine and an appropriate thioformimidate is described. Applying this procedure to 5‐O‐benzoyl‐1‐benzylthio‐1‐formimidate‐D‐ribofuranose, 5′ benzoyl‐6‐chloro‐3β‐D‐ribofuranosyl‐s‐triazolo[4,3‐b]pyridazine was obtained. Substitutions of chlorine by nucleophilic reagents afforded some derivatives of a new series ofC‐nucleo‐sides. Structural determination including anomeric configuration assignment

ISSN:0022-152X    

DOI:10.1002/jhet.5570180509

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY

摘要:

AbstractStarting from the readily available 4‐bromomethy‐5‐carbethoxy 1,2,3‐thiadiazole (V), 5‐bromomethy‐4‐carbethoxy‐1,2,3‐thiadiazole (IX) and ethyl 2‐aryl‐5‐bromomethyloxazole‐4‐carboxylate (XIV), 4,10‐dihydro‐10‐oxo[1]benzoxepino[3,4‐d][1,2,3]thiadiazole (Ia), 4,10‐dihydro‐10‐oxo[1]benzothiepino[3,4‐d][1,2,3]thiadiazole (Ib), 4,10‐dihydro‐4‐oxo[1]benzothiepino[4,3‐d] [1,2,3]thiazole (II), 2‐aryl‐4,10‐dihydro‐4‐oxo[1]benzoxepino[4,3‐d]oxazoles (XIXa‐XIXc) and 2‐aryl‐4,10

ISSN:0022-152X    

DOI:10.1002/jhet.5570180510

出版商:Wiley‐Blackwell    

年代:1981

数据来源: WILEY