摘要:

AbstractMethyl (3,6‐dichloropyridazin‐4‐yl)acetate (II), prepared from methyl (3,6‐dihydroxypyrid‐azin‐4‐yl)aeetate (1) by chlurination with phosphorus oxychloride, was used for studies of nucleo‐philic displacement reactions and it has been found that only the chlorine atom at position 6 was displaced with hydrazine. With diluted hydrochloric acid both chlorine atoms were displaced with the 6‐oxo isomer predominating. By turning the aromatic ring of pyridazine into ano‐quinoid system, the chlorine atom at position 3 became mobile. Cyelization of (6‐hydrazino‐s‐triazolo‐[4,3‐b ]pyridazin‐7‐yl)acetic acid hydrazide (XIX) gave 6‐aminopyrrolo[3,2‐e]s‐

ISSN:0022-152X    

DOI:10.1002/jhet.5570130601

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractThe synthesis of indenothiophenes and substituted compounds is described starting from indaneviaindanaldehyde. A separation of the isomeric indanaldehydes is developed.

ISSN:0022-152X    

DOI:10.1002/jhet.5570130602

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractTreatment of 7‐chloro‐3,4‐dihydro‐1H‐1,4‐benzodiazepin‐2,5‐dione (Ia) with refluxing acetic anhydride in the presence of pyridine afforded 6‐chloro‐2‐methyl‐4H‐3,1‐benzoxazin‐4‐one (IIa). A plausible reaction path for this novel rearrangement reaction is described: Ia → 4‐acetyl‐7‐chloro‐3,4‐dihydro‐lH‐1,4‐benzodiazepin‐2,5‐dione → 7‐chloro‐1,4‐diacetyl‐3,4‐dihydro‐lH‐1,4‐benzodiazepin‐2,4‐dione → IIa. When 7‐chloro‐3,4‐dihydro‐4‐methyl‐lH‐1,4‐benzodiazepin‐2,5‐dione (Ib), 3,4‐dihydro‐4‐methyl‐1H‐1,4‐benzodiazepin‐2,5‐dione (Id) and 3,4‐dihydro‐1‐methyl‐1H‐1,4‐benzodiazepin‐2,5‐dione (Ie) were allowe

ISSN:0022-152X    

DOI:10.1002/jhet.5570130603

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractLa cycloaddition de l'oxyde de benzonitrile sur la diméthyl‐1,2 phényl‐5 A‐3‐pyrazoline est un exemple de réaction régiospécifique et stéréoselective. La structure des diméthyl‐5,6 diphényl‐3,4 pyrazolidino[4,3‐d]isoxazoline‐2 épiméres est démontree. Le passage à l'isomére le plus

ISSN:0022-152X    

DOI:10.1002/jhet.5570130604

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractLa détermination du site de quaternarisation de molécules bicycliques contenant 2 atomes d'azote sp3vicinaux dans un cycle et un azote sp2dans l'autre est realisee par des études spectrales et par dégradation des iodométhylates obtenus. La quaternarisation qui se fait sur un des 2 azotes sp3est controlée par les effets ster

ISSN:0022-152X    

DOI:10.1002/jhet.5570130605

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractThe condensation of 2,3‐dihydro‐6‐methoxy‐4H‐benzopyran‐4‐one (1) and 6‐nitroveratr‐aldehyde (2) gave the expected 2,3‐dihydro‐6‐methoxy‐3‐(6‐nitroveratrylidene)‐4H‐benzopyran‐4‐one (3) plus an unexpected product identified as 2,3‐dihydro‐3‐(α‐ethoxy‐4,5‐dimethox

ISSN:0022-152X    

DOI:10.1002/jhet.5570130606

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractAlthough the previously reported (1,2) chemical reduction of 2,3‐dihydro‐3‐(6‐nitroveratry‐lidene)‐4H‐benzopyran‐4‐one with stannous chloride occurred with cyclization to the 6H‐[1]‐benzopyrano [4,3‐b]quinoline ring system, the present study of the catalytic (palladium/carbon) reduction of 2,3‐dihydro‐6‐methoxy‐3‐(6‐nitroveratrylidene)‐4H‐benzopyran‐4‐one (1) (3) has indicated that other products in addition to the expected benzopyranoquinoline (3) may be isolated, depending upon the conditions of the reduction. The products of the reduction of1, isolated and structurally determined, include 2,9,10‐trimethoxy‐6H‐[1]benzopyrano‐[4,3‐b]quinoline(3),2,9,10‐trimethoxy‐6a,7,12,12a‐tetrahydro‐6H‐[1]benzopyrano[4,3‐b]‐quinoline (2), theN‐oxide of3 (6), a

ISSN:0022-152X    

DOI:10.1002/jhet.5570130607

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

Abstract1,2,3,4,8,9,10,11‐Octahydro[1,4]diazepino[6,5,4‐jk]earbazole (VIa) was synthesized from 2,3,4,5‐tetrahydro‐1H‐benzodiazepine (la)viathe route shown in Scheme 1. Other compounds which were prepared similarly are 3‐acetyl‐6‐chloro‐1,2,3,4,8,9,10,11‐octahydro[1,4]diazepino‐[6,5,4‐jk]carbazole(Vb) and 3‐methyl‐1,2,3,4,8,9,10,11‐octahydro[1,4]diazepino[6,5,4‐jk]carb‐azole (VIII). Chemical transformations which were carried out with VI and 3‐acetyl‐1,2,3,4,8,9, 10,11‐octahydro[1,4]diazepino[6,5

ISSN:0022-152X    

DOI:10.1002/jhet.5570130608

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractThe rate of selenium catalyzedcis‐transisomerization of stilbene, 2‐styrylfuran and 2‐styryI‐thiophene in decahydronaphthalene has been studied in the temperature range 170‐190° by gas chromatographic analysis. Rate constants were pseudo first order and gave the following reactivity order: e(.s‐stilbene

ISSN:0022-152X    

DOI:10.1002/jhet.5570130609

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY

摘要:

AbstractRefluxing thieno[2,3‐b ]pyridine 7‐oxide (1) with aeetic anhydride plus subsequent hydrolysis produced a mixture of thieno[2,3‐b]pyrid‐6(7H)one (2) (13%) and 5‐hydroxythieno[2,3‐b]‐pyridine (4) (4%). Refluxing 1 with phosphorus oxychloride yielded a mixture of 4‐ and 6‐chloro‐thieno[2,3‐b]pyridines, (5) (54%) and (6) (31%), respectively. Compound6was also obtained directly from2(31%). A mechanistic rationalization for the isomerization of 1 to form 2 and 4 is presented. Marked differences in the mass spectral fragmentations of these three isomeri

ISSN:0022-152X    

DOI:10.1002/jhet.5570130610

出版商:Wiley‐Blackwell    

年代:1976

数据来源: WILEY