摘要:

AbstractA new one‐pot synthesis of 4‐acylimino‐2‐aminothieno[2,3‐d][1,3]thiazines4and5, respectively, from 2‐thioureidothiophene‐3‐carbonitriles1, acetic, propionic anhydride, respectively, and concentrated sulfuric acid is reported. The structure of4ais confirmed by X‐ray s

ISSN:0022-152X    

DOI:10.1002/jhet.5570290201

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractTriethyl phosphite deoxygenation of 2‐(2‐nitrophenyl)imidazo[1,2‐a][1,8]naphthyridine(3)led to theC‐insertion to give the indoloimidazonaphthyridine5.Our attempt to promote theN‐insertion by blocking the C‐3 position failed. Triethyl phosphite deoxygenation of 1‐nitroso‐2‐(4‐fluorophenyl)imidazo[1,2‐a][1,8]‐naphthyridine(12)led to the corresponding amine structure(15).Thermolysis and photolysis of 6,8‐dimethyl‐2‐(2‐azidophenyl)imidazo[1,2‐a][1,8]n

ISSN:0022-152X    

DOI:10.1002/jhet.5570290202

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractLong chain derivatives of halogen free carbazoledioxazine which is a typical organic pigment with a linear type structure (5,15‐dialkyl‐5,15‐dihydrodiindolo[3,2‐b:3′,2′‐m]triphenodioxazines) and an angular type structure (5,15‐dialkyl‐7,17‐dialkoxy‐5,15‐dihydrodiindolo[2,3‐c:2′,3′‐n]triphenodioxazines) were newly synthesized. Their structures were confirmed by1H‐nmr, ms and elemental analysis. The thermal, spectroscopical and electrochemical properties were investigated by means of D

ISSN:0022-152X    

DOI:10.1002/jhet.5570290203

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe conformation of compounds1and2has been determined in the solid state by X‐ray crystallography and in solution by nmr spectroscopy. MM2 and molecular dynamics calculations were used to determine the conformation of compound2in vacuoand in solutio

ISSN:0022-152X    

DOI:10.1002/jhet.5570290204

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe ethylaluminum dichloride catalyzed Michael‐type addition of indoles1a‐hto theN‐(diphenylmethylene)‐α,β‐didehydroamino acid esters2a‐callows a new synthesis of β‐methyltryptophanes41,mand a new route for 1,1‐diphenyl‐3‐carbalkoxy‐1,2,3,4‐t

ISSN:0022-152X    

DOI:10.1002/jhet.5570290205

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe crystal and molecular structures of isomeric compounds of 1‐(4′‐chlorobenzoyl)‐2‐(2″‐hydroxynaphthyl)‐3,3‐Dimethylindoline have been determined by single crystal X‐ray analyses as a pair of diastereomeric atropisomers due to restricted rotation ab

ISSN:0022-152X    

DOI:10.1002/jhet.5570290206

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe study of the molecular geometry of 1,5‐bis(3,5‐dimethyl‐2‐hydroxybenzyl)‐1,5‐diazocan‐2,6‐dione(2)as determined by X‐ray analysis is reported and compared with that of cyclodi‐β‐alanyl(3).Interestingly there are 1.5 molecules of2in the asymmetric unit, showing the two conformations (1 twist‐boat‐ and 0.5 chair‐type) with two parallel aromatic rings (from alternate twist‐boat conformers) sandwiching the eight‐membered ring of the centrosymmetric chair‐type conformation. The twist‐boat is shown by pmr spectroscopy to be the only significantly populated conformer at low temperature

ISSN:0022-152X    

DOI:10.1002/jhet.5570290207

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractThe tautomerizableN‐aminopyrazolone9, theO‐methyl1andN‐methyl derivatives4were condensed with carbonyl compounds to give the alkenylaminopyrazoles12, 2a‐gand5c, which, under mild conditions, were hydrogenated to the corresponding alkylamino derivatives. The subsequent hydrogenation of the latter ones gave different results according to the structure of the starting material. The 5‐methoxy‐1‐alkylamino‐pyrazoles3a‐gyielded the 5‐methoxypyrazole15and the corresponding primary amines in good yields. On the contrary,N‐methyl‐1‐alkylaminopyrazolone‐5

ISSN:0022-152X    

DOI:10.1002/jhet.5570290208

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractTheN‐aryl‐ andN‐heteroaryl‐2,5‐dimethylpyrrole‐3‐carbaldehydes2–8have been synthesized by condensation of hexane‐2,5‐dione with the appropriate amine and subsequent Vilsmeier‐Haack formylation of the pyrrole ring. Diastereomeric association complexes of the racemic pyrrole8were studied by pmr chemical shifts and the splittings induced by (+)‐1‐(9‐anthryl)‐2,2,2‐trifluoroethanol. Enrichment of the enantiomersMandPof2and6was achieved by liquid chromatography on triacethylcellulose. The barrier to partial rotation about the C‐N bond in6was determined by thermal racemization and its l

ISSN:0022-152X    

DOI:10.1002/jhet.5570290209

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY

摘要:

AbstractA series of N‐1 or C‐2 phenylalkyl substituted tryptophans and C‐1 phenylalkyl substituted 3,4‐dihydro‐β‐carbolines were prepared from the apropriate aniline,1bor1e, or tryptophan,8or11, by ring closure methods. None of the compounds prepared were more potent than 5‐bromotryptophan(11)as inhibitors of sickle cell hemog

ISSN:0022-152X    

DOI:10.1002/jhet.5570290210

出版商:Wiley‐Blackwell    

年代:1992

数据来源: WILEY