摘要:

AbstractLa synthèse d'hydrazides pyrroliques a été effectuée à partir de l'hydrazide de l'acide pyrrole‐carboxylique‐2 et celle d'hydrazones pyrroliques à partir du pyrrole‐carboxaldéhyde‐2. Les pyrrolyl‐2 oxadiazoles et thiadiazoles sont accessibles par cyclisation des hydrazides pyrroliques avec l'oxychlorure et le décasulfure de phosphore. Ces dérivés sont destinés à la synthèse de pyrrolo[1,2‐d]triazines‐1,2,4 par cyclis

ISSN:0022-152X    

DOI:10.1002/jhet.5570170401

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractLa synthèse des dihydro‐1,2 oxo‐1 pyrrolo[1,2‐d]triazines‐1,2,42est effectuée soit par transposition en milieu alcalin de pyrrolyl‐2 oxadiazoles, soit par cyclisation deN‐éthoxyméthylidène‐hydrazides pyrroliques. La dihydro‐3,4 oxo‐4 pyrrolo[1,2‐d]triazine‐1,2,45aest accessible par cyclisation en milieu alcalin de laN‐carbéthoxyhydrazone du formyl‐2 pyrrole. Les réactions de substitution électrophile des pyrrolotriazinones‐1 et ‐4 sont réalisables soit au niveau de l'azote lactamique avec des agents électrophiles tels que le sulfate diméthylique, le chlorure de benzyle ou l'acide monochloracétique, soit au niveau du cycle pyrrolique avec le brome ou l'acide nitrique. Les structures de

ISSN:0022-152X    

DOI:10.1002/jhet.5570170402

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe natural abundance carbon‐13 nuclear magnetic resonance spectra of various 5‐aryltetrazoles, 1‐(5‐aryltetrazol‐2‐ylacetyl)‐4‐phenyl thiosemicarbazides and 5‐(5‐aryltetrazol‐2‐ylmethyl)‐4‐phenyl‐s‐triazole‐3‐thiols were recorded using Fourier transform techniques. The chemical shifts of various carbon resonances have been assigned on the basis of chemical shift theory, the signal multiplicity observed in the single‐frequency off‐resonance decoupled (SFORD) spectra and comparison with the

ISSN:0022-152X    

DOI:10.1002/jhet.5570170403

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractOxidative cyclization of morusin (I) by using one‐electron transfer oxidizing agents (manganese dioxide, silver oxide) afforded morusin hydroperoxide (II). A similar reaction was carried out in the presence of 2,4,6‐tri‐t‐butylphenol, a radical quencher, to give compounds (IV, V, VI and VII) coupled with the 2,4,6‐tri‐t‐butylphenoxy radical. On the basis of above results, the possible mechanism of this oxidative cyclization was discussed. In addition, morusin hydroperoxide (II) was also obtained by photo‐sensitized oxidation of morusin (I) in the presence of sensitizers (Rose Bengal, hematoporphyrin). To elucidate the reaction mechanism similar reactions were carried out in the presence of radical quencher (2,4,6‐tri‐t‐butylphenol) or singlet oxygen quencher (triethylenediamine). From these results, the possible mechanism of the formation of morusin hydroperoxide (II) from moru

ISSN:0022-152X    

DOI:10.1002/jhet.5570170404

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe reaction of alkylpyrazine anions with iodine, 1,2‐dibromoethylene or oxygen gives 1,2‐bis‐(2‐pyrazyl)

ISSN:0022-152X    

DOI:10.1002/jhet.5570170405

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractProton spin‐lattice relaxation rates (R1values) have been measured, at 270 MHz, for a series ofN‐aryl isoindolinones. A normalization procedure has been used to enable comparison of R1values in different compounds by minimizing the effects on relaxation rates of changes in motional correlation times accompanying changes in substitution patterns. A substantial (4.3‐fold) dynamic range of R1values has been observed, and individual values have been correlated with the molecular environments of the nuclei. There is evidence for an interring relaxation pr

ISSN:0022-152X    

DOI:10.1002/jhet.5570170406

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe cyclization of 3,5′‐dichloro‐2′‐phenoxypropionanilide (2) to a trimeric cyclohexane4and of 4‐bromo‐5′‐chloro‐2′‐phenoxybutyranilide (1) to a tetracyclic pyrro

ISSN:0022-152X    

DOI:10.1002/jhet.5570170407

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractThe syntheses of two compounds, which are fused‐ring succinimides, prepared as potential anticon‐vulsants, are described. The compounds are 3,4,5,6‐tetrahydro‐7‐methyl‐6‐oxoindeno[7,1‐bc]thiepin‐4a,5‐(2H)dicarboximide and 6,7,8,9‐tetrahydro‐2‐oxo‐1H‐benz[cd]azulene‐1,9a‐(2H)dicarboximide. The spirodioxolane of the latter compound

ISSN:0022-152X    

DOI:10.1002/jhet.5570170408

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractReaction of 2‐Chloromethyl‐3‐hydroxy‐4(3H)quinazolinone (1) with aliphatic amines and hydroxide follows two different routes affording substituted methyl quinazolinones and a dimer2derived from1. The former were formed by SN2reactions while the latter was formed by an inter‐molecular nucleophilic displacement. Second‐order and third‐order rate constants, respectively, were determined, and the kinetic factors influencing both parallel reactions

ISSN:0022-152X    

DOI:10.1002/jhet.5570170409

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY

摘要:

AbstractL'action des isocyanates sur les benzisothiaxol‐2,1 ones‐3 (1H) et sur les thiadiazol‐1,2,4 ones‐5 a été étudiée. En présence de quantité stoechiométrique de base organique elle conduit, dans les deux cas, à l'incorporation de deux atomes de l'isocyanate dans l'hétérocycle, avec extrusion simultanée de

ISSN:0022-152X    

DOI:10.1002/jhet.5570170410

出版商:Wiley‐Blackwell    

年代:1980

数据来源: WILEY