摘要:

AbstractThe selective formation of 1,3,5,7‐tetrazacyelooctanes from the title compounds is described. Exclusive cleavage of the IN‐CH2‐N bonds at the bridge methylene is shown to be a facile process, thus providing a convenient route to tetrazacyclooctane deriva

ISSN:0022-152X    

DOI:10.1002/jhet.5570100301

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractA facile route for the synthesis of pyrrolo[ 1,2‐α]pyrimidine derivatives and data for structural assignment are report

ISSN:0022-152X    

DOI:10.1002/jhet.5570100302

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractAn attempt to obtain 2,3,4,5,6,7‐hexahydro‐lH2,7‐methano‐9‐methoxy‐3‐rnethyl‐7‐phenyl‐2,3‐benzodiazonine (II) by the Pictet‐Spengler reaction of 2,3,4,5,6,7‐hexahydro‐lH‐4‐(3‐meth‐oxyphenyl)‐l‐methyl‐4‐phenyl‐1,2‐diazepine (XI) prepared through several steps from 1‐(3‐methoxyphenyl)phenylaeetonitrile (IV) resulted instead, in the formation of 1,2,3,4,5,6‐hexa‐h

ISSN:0022-152X    

DOI:10.1002/jhet.5570100303

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe sulfur analog of psilocin, 3‐(β‐dimethylaminoethyl)‐4‐hydroxybenzo[b]thiophene, and someO‐methylated andN‐demethylated isomers have been synthesized for pharmacological evaluation. Preliminary tests indicate central nervous system (CNS) activity, but weak pres

ISSN:0022-152X    

DOI:10.1002/jhet.5570100304

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe reaction of 1,2,3,5‐telrahydro‐6‐methoxy‐1 ‐[2‐(4‐methoxy‐1,4‐eyelohexadien‐1 ‐yl)eth‐yl]‐l‐methyl‐7‐isoquinolinol (12) with hot phosphoric acid afforded (±)‐tetrahydro‐homoglazio‐vine (14) in good yield. Similar treatment of 1,2,3,4‐tetrahydro‐6‐methoxy‐l ‐[2‐(4‐methoxy‐1,4‐cyelohexadien‐l‐yl)methyl]‐2‐methyl‐7‐isoquinolinol (13) did not produce the desired (±)‐tetra‐hydroglaziovine (18) but rather a mixture of diastereomeric 4,5,6,6aϵ,7,7aϵ,8,9,11, 11aϵ‐deca‐hydro‐l‐hy

ISSN:0022-152X    

DOI:10.1002/jhet.5570100305

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractAcid treatment of the alkylated products of (Va, Vb, and VIII) of piperidinols IVa and IVb, and tetrahydropyridine VII with β‐bromoethylbenzene, afforded 1,2,3,4,5,6‐hexahydro‐8‐hydroxy‐2,6‐methano‐6,1 1‐dimethyl‐3‐phenethyl‐3‐benzazocine (la) in good yield. Piperidinols Va and Vb were also obtained from the reaction ofN‐(3‐methyl‐3‐pentenyl)‐β‐phenethylamine (IIb) with methyl 3

ISSN:0022-152X    

DOI:10.1002/jhet.5570100306

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe reaction of a 2‐acylphenylacetic acid derivative (I) with primary amines in glacial acetic acid produces novel, colorless aminonaphthols (III) which are isomeric with the brilliant yellow 3(2H)isoquinolones (II) obtained in the same reaction. A combination of chemical and spectral techniques allowed identification of the isomers as derivatives of 4‐amino‐2‐naphthol. A plausible mechanism of formation of aminonaphtholsversus3(2H)isoquinolones is discussed and supported by chemical synthesis ofN‐substituted 2‐aeylphenylacetamides (VIII) and a 1,4‐dihydro‐1‐hydroxy‐3(2H)isoquinol

ISSN:0022-152X    

DOI:10.1002/jhet.5570100307

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe Diels‐Alder reaction of 4,5‐dimethylene‐2,2‐diphenyldioxolane with diethyl azodicar‐boxylate and 4‐phenyl‐1,2,4‐triazoline‐3,5‐dione was investigated. Reduction of the resultant adducts followed by hydrolysis provided hexahydro‐4,5‐dihydroxy‐1,2‐pyridazine dicarboxylic acid diethylester and 1,3,5,6,7,8‐hexahydro‐6,7‐dihydroxy‐2‐pheny 1‐2H

ISSN:0022-152X    

DOI:10.1002/jhet.5570100308

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractIsomericcis‐ andtrans‐imidazopyrrolones, obtained from the reaction of pyromellitic di‐anhydride ando‐phenylenediamine, were prepared as models for pyrrone polymers. The characterization of these model compounds, which represent the repeat unit of the completely cyclized polymer, provided information which could not be obtained by studying the polymer itself. Isomerism was proven by the nuclear magnetic resonance spectra of soluble ester‐benzimidazole derivatives. This study indicated that a single band around 1755 cm−1should appear in the infrared spectrum of the completely cyclized polymer. The high melting points of the model imidazopyrrolones indicate the extreme thermal stability to be anticipated from perfectly formed pyrro

ISSN:0022-152X    

DOI:10.1002/jhet.5570100309

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

Abstract2‐[2‐(2,4‐Dimethyl‐3‐oxopentyl)]benz, imidazoles (2‐10) were obtained by allowingo‐phenyl‐enediamines to react with 2,2,4,4‐tetramethyl‐1,3‐cyclobutanedione (1). When refluxed with acetic anhydride (or sterically unhindered homologs) they cyclize in the presence of base to yield the pyrido[1,2‐α]benzimidazoles (16‐21and24, 25). The 2‐[2‐(2,4‐dimethyl‐3‐oxo‐pentyl) ]imidazolines (12and14) were obtained by reaction of 1,2‐diaminoethane and 1,2‐diaminopropane, respectively, with1. When allowed to react with acetic anhydri

ISSN:0022-152X    

DOI:10.1002/jhet.5570100310

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY