摘要:

AbstractNew syntheses of 4,5,6,7‐tetrahydrofuro[2,3‐c]pyridines and furo[2,3‐c]pyrrolidine derivatives, starting from furan‐3‐carboxaldehyde, are

ISSN:0022-152X    

DOI:10.1002/jhet.5570270501

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractZinc chloride‐catalyzed rearrangement of 1‐N‐allylindoline and 1‐N‐(2‐methylallyl)indoline proceeds readily in refluxing xylene to give 7‐allylindoline and 7‐(2‐methylallyl)indoline in 73% and 86% yields, respectively. The reaction of 1‐N‐2‐butenylindoline and zinc chloride give rise to the mixture of 7‐(1‐methylallyl)indoline, 7‐(cis‐ andtrans‐1‐methyl‐1‐propenyl)indoline, and 7‐(trans‐2‐butenyl)indoline. On the other hand, the similar reaction of 1‐N‐(3‐methyl‐2‐butenyl)indoline with zinc chloride led to the formation of a mixture of 1,2,5,6‐tetrahydro‐4,4‐dimethyl‐4

ISSN:0022-152X    

DOI:10.1002/jhet.5570270502

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractThe 6‐ and 7‐(1‐ethylbenzimidazolyl)‐substituted 1‐ethyl‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acids were synthesized. Antibacterial activity was testedin vitro. Only one of the new compounds prepared showed slight antibacterial activity against one of the strains tested. So, they are of no interest as

ISSN:0022-152X    

DOI:10.1002/jhet.5570270503

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractUnsubstituted5, and 2‐aryl‐6a‐c, or 2‐(2‐benzothiazolyl)‐substituted 1,3‐dihydroisochromano[4,3‐c]pyrazol‐3(2H)‐ones7a‐fwere prepared by the reactions of 3‐ethoxyoxalyl‐2, or 3‐ethoxycarbonylisochroman‐4‐one3with hydrazine derivatives. The reactions with amidines gave 2‐substituted 4‐hydrox

ISSN:0022-152X    

DOI:10.1002/jhet.5570270504

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractReactions of stable nitrile oxides with cycloalkano[b]indoles gave as main product adducts3containing the oxadiazolo[4,5‐a]indoline ring system. The structure elucidation of the isolated adducts was based on their spectral data, chemical behaviour and in one case the structure was confirmed by crystallographic X‐ray analysis. The mechanism of the reaction is also discus

ISSN:0022-152X    

DOI:10.1002/jhet.5570270505

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractThe syntheses of the K‐imine derivatives of benzo[h]quinoline (1), benzo[f]quinoline (2) and 1,10‐phenanthroline (3) are described. The parent nitrogen heterocycles were oxidized with sodium hypochlorite to the corresponding K‐oxides,4, 6and8, which in turn were reacted with sodium azide. The resulting azido alcohols were then cyclized with triethyl phosphite to the title compounds5, 7and9. The oxirane ring cleavage in benzo[h]quinoline 5,6‐oxide (4) and in benzo[f]quinoline 5,6‐oxide (6) by sodium azide proceeded by the predicted regioselectivity:4gavetrans‐5‐azido‐5,6‐dihydro‐6‐benzo[h]quinolinol (11) andtrans‐6‐azido‐5,6‐dihydro‐5‐benzo[h]quinolinol (10) as the major and minor products respectively, and6yielded solelytrans‐6‐azido‐5,6‐dihydro‐5‐benzo[f]quinolinol (12). The latter compound proved by X‐ray ana

ISSN:0022-152X    

DOI:10.1002/jhet.5570270507

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractA series of twelve newly synthesized derivations of 3‐benzoyl‐4,7‐dihydro‐7‐oxopyrrolo[3,2‐b]pyridine‐6‐carboxylic acid from 2‐methyl‐3‐benzoyl‐4

ISSN:0022-152X    

DOI:10.1002/jhet.5570270508

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

Abstract3‐Acetylpyrroles are brominated with copper(II) bromide. The reaction afforded almost quantitatively only nuclear monobromination. Evidence for the structures of final compounds was by mass spectrometry,1H‐nuclear magnetic resonance, ir, and elemental analy

ISSN:0022-152X    

DOI:10.1002/jhet.5570270509

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractBiguanides and the related compounds, in which a moiety of biguanide is involved in the structure as a part of the ring, were allowed to react with diethyl azodicarboxylate to afford triazinones and fused heterocycles including a triazinone ring, respectively. The mechanism of the reaction was elucidated to proceed through the initial formation of the amide intermediate, followed by cyclization to triazinone ring systems with elimination of nitrogen.

ISSN:0022-152X    

DOI:10.1002/jhet.5570270510

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY

摘要:

AbstractMethyl 3‐(N‐arylamino)‐2‐cyano‐3‐methylthioacrylates3a‐h, which are readily prepared by the reaction of the ketene dithioacetal, methyl 2‐cyano‐3,3‐bis(methylthio)acrylate (1) with arylamines, was heated at reflux in diphenyl ether to give the corresponding 2‐methylthio‐4‐hydroxyquinoline‐3‐carbonitriles4a‐hin 14–77% yields. The reaction of1with excess aryl amines in diphenyl ether at reflux gave also the corresponding 2‐arylamino‐4‐hydroxyquinoline‐3‐carbonitriles6a‐d. The 2‐methylthioquinoline‐3‐carbonitriles4a‐h, thus obtained, are useful intermediat

ISSN:0022-152X    

DOI:10.1002/jhet.5570270511

出版商:Wiley‐Blackwell    

年代:1990

数据来源: WILEY