摘要:

AbstractA series of 2, 2′‐bithienyl derivatives were synthesized starting from the coupling of 2, 2′‐bithienyl and 2‐(2‐iodoethyl)‐1

ISSN:0022-152X    

DOI:10.1002/jhet.5570260301

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractThe oxidation of some 3‐(methoxy‐ and ethoxycarbonyl)tetrahydro‐β‐carboline derivatives with sodium periodate led to the formation of 1, 4‐benzodiazonine derivatives or fully aromatic β‐carbolines depending on both nature and number of substituents

ISSN:0022-152X    

DOI:10.1002/jhet.5570260302

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractProcedures are described for the preparation of various bidentate and potentially tridentate chelating agents. These incorporate pyridyl, benzimidazole, imidazole or phenolic moieties. Phillips condensations of carboxylic acids witho‐phenylenediamines were carried out in 4Mhydrochloric acid. Syntheses are reported for 2, 6‐bis(N′‐methylimidazol‐2′‐ylthiomethyl)pyridine, 2, 6‐bis(benzimidazol‐2′‐ylthiomethyl)pyridine, 2‐(4′‐piperidyl)benzimidazole, 2‐(3′‐piperidyl)benzimidazole, 2‐(3‐N′‐methylpiperidyl)benziinidazole, 2‐(3‐N′‐methylpiperidyl)‐N‐methylbenzimidazole, 2‐(2′‐hydroxybenzyl)benzimidazole and 2‐(2′‐hydroxyben‐zyl)N‐methylbenzimidazole. The compounds were characterized where appropriate by their mass, uv, and1H‐nmr spectra. 2‐(2′‐Hydroxyb

ISSN:0022-152X    

DOI:10.1002/jhet.5570260303

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractNovel tetracyclic ring systemsviz.3‐methyl‐1‐oxo‐12H‐1, 2, 4‐triazepino[3′,4′:3, 4][1, 2, 4]triazino[5, 6‐b]indole (4a) and 3‐methyl‐5‐oxo‐12H‐1, 2, 4‐triazepino[4′,3′:2, 3][1, 2, 4]triazino[5, 6‐b]indole (5a), having angular and linear structures respectively, were synthesized by the cyclization of 3‐oxobutanoic acid [5H‐1, 2, 4‐triazino‐[5, 6‐b]indole‐3‐yl]hydrazone (3a). However, cyclization of3b(R = CHa, R1= R2= H) afforded the angular product4bexclusively. Moreover, cyclization of3c(R = R3= H, R1= F) yielded 7‐fluoro‐1‐0xo‐10H‐1, 3‐imidazo[2′,3′:3, 4][1, 2, 4]triazino[5, 6‐b]indole (6c) and 7‐fluoro‐3‐oxo‐10H‐1, 3‐imidazo[3′,2′:2, 3][1, 2, 4]triazino‐[5, 6‐b]indole (7c) instead of the expected triazepinone derivatives. Compound3d(R = R1= H, R2= CF3) also gave an imidazole derivative but only one angular product was obtained. In all these reactions, formation of the angular product involving cyclization at N‐4 is favoured. Characterization of these

ISSN:0022-152X    

DOI:10.1002/jhet.5570260304

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractEvidence is presented to indicate that the reductive reaction of the isochromanone derivative 1 by means of lithium aluminium hydride (LAH), yielded the isochroman 2 together with small amounts of naphthalene derivatives. All new compounds have been identified from spectroscopic and analytical data.

ISSN:0022-152X    

DOI:10.1002/jhet.5570260305

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractA study of the cycloaddition behaviour of substituted pyridazin‐3‐ones with arylnitrile oxides has been carried out, Nitrile oxides udergo site and regioselective 1, 3‐dipolar cycloaddition to 4, 5‐double bond of pyridazinone to afford 3a, 7a‐dihydroisoxazolo[4, 5‐d]pyridazin‐4‐ones. The reactions follow frontier orbital predictions. Nitrile oxide HOMO‐pyridazinone LUMO combin

ISSN:0022-152X    

DOI:10.1002/jhet.5570260306

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractPreparation of two new analogs5and6of the antitumor antibiotic CC‐10651are described. These compounds represent structural modifications of the active analogs3and2respectively, in which the dienone A‐unit has been replaced by the tricyclic achiral gramine unit4. Modest cytotoxicity was exhibited by compounds5a

ISSN:0022-152X    

DOI:10.1002/jhet.5570260307

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractNew diaza‐crown compounds with the macro ring nitrogen atoms situated in the 1, 4‐, 1, 7‐ and 1, 10‐positions have been prepared. All of the new macrocycles contain alkyl groups on the nitrogen atoms and a functional group substituent in the form of either an allyloxymethyl, allyloxy or hydroxy group on one of the macro ring carbon atoms. A 1, 4‐diaza‐crown attached to silica gel removes Hg(II) ions from an aqueous mixture of Hg(II), Cd(II) and

ISSN:0022-152X    

DOI:10.1002/jhet.5570260308

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractA series of pyrrolo[2, 1‐a]phthalazine derivatives has been prepared including examples carrying a variety ofO‐ andN‐substituents at position‐6. A number of the products and related tricyclic structures show mild anti‐hypertensive activity including 6‐allyloxy‐1, 2‐dichloro‐3‐phenylpyrrolo

ISSN:0022-152X    

DOI:10.1002/jhet.5570260309

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY

摘要:

AbstractDeux chloro‐10‐5H‐isoquino[6, 7‐b][1, 6]naphtyridones‐12 ont été synthétisées au départ d'acides chloro‐4 nicotiniques et de l'amino‐6 méthyl‐5 2H‐isoquinolone‐1, cyclisation des acides intermédiaires par l'acide sul‐furique ou l'acide trifluorométhanesulfonique puis chloration par l'oxychlorure de phosphore.La comparaison de la cytotoxicité des diéthylamino‐propylamino‐10 méthyl‐6‐H‐isoquino[6, 7‐b][1, 6]naphtyridones‐12‐obtenues par substitution des dérives chlorés‐ avec celle des aza‐9 ellipticines qui leur sont appar‐entées, montre que le remplacement du noyau pyrrole par un

ISSN:0022-152X    

DOI:10.1002/jhet.5570260310

出版商:Wiley‐Blackwell    

年代:1989

数据来源: WILEY