摘要:

AbstractN‐[2‐(D‐Glucos‐3‐O‐yl)propionyl]‐L‐alanine (7a) was synthesized, which has a glucose residue instead ofN‐acetylglucosamine residue in the muramyl peptide.N‐[(D‐Glucos‐3‐O‐yl)acetyl]‐L‐alanine (7b) was also synthesized as a glycolyl analog of7ain order to determine the relationship between the structure of propionyl moiety in the carbohydrate analog (7a) and the adjuvant activity. These simple analogs are compounds prepared for the purpose of introduction into a synthetic polymer with the vi

ISSN:0022-152X    

DOI:10.1002/jhet.5570190501

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractTwo diastereoisomeric thietane 1,1‐dioxides are formed in the reaction of methanesulfonyl chloride with4‐t‐butylcyclohexanone enamines in the presence of triethylaraine. Their structures and relative chemical stabilities are disc

ISSN:0022-152X    

DOI:10.1002/jhet.5570190502

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe synthesis and biological activities of some 4‐oxo‐1‐or‐2‐substituted 1H‐or‐2H‐pyrano[4,3‐c]pyrazole derivati

ISSN:0022-152X    

DOI:10.1002/jhet.5570190503

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

Abstract2‐Carboxy‐1‐alkylindole‐3‐acetic acid anhydrides (I) condensed withS‐methylisothiosemicarbazide in DMF to form 5,11‐dihydro‐6‐methyl‐2‐methylthioindolo[3′,2′:4,5]pyrido[1,2‐b]‐s‐triazol‐5‐one (II). Compound II underwent ring opening on refluxing with sodium hydroxide solution to give IV. The anhydride I reacted with primary amines in benzene to give 2‐carboxy‐1‐alkylindole‐3‐acetanilide derivatives (VI) which yielded l‐methylindole‐3‐acetic acid by decarboxylation followed by hydrolysis. Compound II oxidised to the diketo compound X which could be prepared by the hydrolysis of the azomethine derivative IX with acetic acid‐hydrochloric acid mixture. Compound II reacted with benzyl chloride to yield the dibenzyl derivative XII, condensed withp‐chlorobenzaldehyde to form the 11‐p‐chlorobenzylidene derivative XI and coupled with arened

ISSN:0022-152X    

DOI:10.1002/jhet.5570190504

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractNucleophilic attack of anthra[1,9‐cd]isoxazol‐6‐ones, and of anthra[1,9‐cd:5,10‐c'd']isoxazole by various sulfoxides, triphenyl phosphine, and aliphatic or aromatic phosphites proceeded with cleavage of the nitrogenoxygen bond of the isoxazole ring. This method provided ready access to substituted anthraquinones bearing sulfoximido‐, triphenylphosphazo‐, and dialkyl(aryl)phosphoramidic groups attached to the 1‐ and the 1,5‐positions of the anthraquinone system. The structures of the newly synthesized anthraquinone derivatives were supported by analytical and spectral data. l‐S,S‐dimethyl‐N‐(5‐benzamidoanthraquinon‐1‐yl)‐sulfoximide yielded in 90% sulfuric acid the l‐amino‐5‐sulfoximido anthraquinone

ISSN:0022-152X    

DOI:10.1002/jhet.5570190505

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe reaction of substituted (Z)‐ and (E)‐2‐arylmethylideneindolin‐3(2H)‐ones with malononitrile gave the Micheal addition products which could be cyclised to the corresponding pyrano[3,2‐b]indole. Larger molecules such as cyanoacetic acid and ethyl cyanoacetate fail

ISSN:0022-152X    

DOI:10.1002/jhet.5570190506

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe preparation of a series of macrocycles, formed by reaction of HO‐(‐CH2‐CH2‐O‐)nH with 1,10‐phenanthroline‐2,9‐dicarbonyl chloride (n = 2,3,4) and 1,8‐naphthyridine‐2,7‐dicarbonyl chloride (n = 3,4), is described. An improved synthetic route to 2,7‐dimethyl‐1,8‐nap

ISSN:0022-152X    

DOI:10.1002/jhet.5570190507

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractReaction of malononitrile with dimethylformamide and phosphorus oxychloride gave (dimethylamino‐methylene)malononitrile (1), 4‐chloro‐7‐methyl‐5,7‐diaza‐1,3,5‐octatriene‐1,1,3‐tricarbonitrile (3a) and the pyridine2. Compounds3aand3bas well as the triaza‐derivative3cmay also be obtained by treatment of tetracyanopropenides4a‐cwith dimethylformamide and phosphorus oxychloride. Ring closures were achieved by heating3under alkaline or acidic conditions. Substitution of chlorine in3awith aromatic amines provided 1‐aryl‐1,2‐dihydro‐2‐imino‐3,5‐pyridinedicarbonitriles7. Hydr

ISSN:0022-152X    

DOI:10.1002/jhet.5570190508

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe syntheses of different 9‐(N‐phthalyl‐ orN‐tosyl‐ or free aminoacyl)carbazoles and the corresponding derivatives of 3,6‐dinitrocarbazoles and some derivatives of 3,6‐diamino‐9‐(N‐phthalylaminoacyl)carbazoles (II‐XXXII) are described. Compounds VIII, XIII‐XVII and XXIII‐XXVII were found to be active against a

ISSN:0022-152X    

DOI:10.1002/jhet.5570190509

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY

摘要:

AbstractThe 1‐alkoxy‐6‐nitro‐1,2,3‐benzotriazole system has been synthesized and characterizedviaits physical and chemical properties. INDO/molecular orbital calculations provide a good account of the major bands in its ultraviolet absorption

ISSN:0022-152X    

DOI:10.1002/jhet.5570190510

出版商:Wiley‐Blackwell    

年代:1982

数据来源: WILEY