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The Influence of Helicobacter pylori Status on Circulating Levels of the Coagulation Factors Fibrinogen, von Willebrand Factor, Factor VII, and Factor VIII |
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Helicobacter,
Volume 1,
Issue 1,
1996,
Page 65-69
Angela M. Carter,
Paul Moayyedi,
Andrew Catto,
Richar M. Heppell,
Anthony T. R. Axon,
Peter J. Grant,
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摘要:
ABSTRACTBackground.Helicobacter pylori (H. pylori)infection has been associated with an increased risk of developing ischemic heart disease (IHD). It has been suggested that a persisting low‐grade acute phase response results from the chronic inflammation caused byH. pyloriinfection, which may give rise to increased circulating levels of certain coagulation factors.Materials and Methods.One hundred three (53 male) nonconsecutive, randomly selected white subjects with symptoms of dyspepsia were recruited for study from an outpatient endoscopy clinic at Leeds General Infirmary. The presence ofH. pyloriwas determined by histological and microbiological investigation, a rapid urease test, and a13carbon urea breath test (13C‐UBT). Fibrinogen was measured by the Clauss method, factor VIII:C (FVIII:C) and factor VII:C (FVII:C) were measured by clotting rate assays, and the von Willebrand factor (vWF) was determined by an enzyme‐linked immunosorbent assay.Results.No difference was found in levels of coagulation factors according toH. pyloristatus. Multiple regression models were used to account for the effect of covariates andH. pyloristatus on levels of FVII:C, FVIII:C, vWF, and fibrinogen, and againH. pyloristatus was not a significant determinant of levels of any of these coagulation factors. No difference occurred in full blood count, platelet count, white cell count, or plasma viscosity in individuals who wereH. pylori‐positive compared with those who were negative.Conclusions.H. pyloriinfection is not associated with increased circulating levels of fibrinogen, FVII:C, vWF.Ag, or FVIII:C or hemorrheology in this patien
ISSN:1083-4389
DOI:10.1111/j.1523-5378.1996.tb00011.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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