ISSN:0741-0395    

DOI:10.1002/gepi.1370110302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0741-0395    

DOI:10.1002/gepi.1370110303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe influence of the guanidine to adenine (G/A) substitution in the promoter region of the apolipoprotein (apo) AI gene (at −75 bp) on serum lipids and apolipoproteins was studied in 287 healthy Chinese of both sexes in Singapore. Women had significantly higher levels of high‐density lipoprotein cholesterol (HDLC) and apo AI and lower low‐density lipoprotein cholesterol (LDLC). The distribution of genotypes was at Hardy‐Weinberg equilibrium. The frequency of the A allele in the Chinese was significantly higher [0.27; 95% confidence interval (CI) 0.24–0.31] than that reported in Caucasians (0.12; 95% CI 0.09–0.14). In men, the A allele was associated with 20% higher apo AI; this association was completely absent in women. Furthermore, in men this association was only observed in those who had never smoked, and was absent in smokers. The G/A substitution explained 9% (P<0.02) of the sample variance of apo AI in non‐smoking men. The modulating influence of smoking could not be examined in women because too few women smoke. Although the impact of this polymorphism is modulated by hormones and smoking, it is of importance in determining levels of apo AI in healthy Chinese individuals. No association of the G/A substitution of the apo AI gene was observed with any other lipid traits. © 1994 W

ISSN:0741-0395    

DOI:10.1002/gepi.1370110304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe effect associated with the substitution of adenine (A) for guanidine (G) in the promoter region of the apolipoprotein AI gene (−75 bp) with plasma apo AI and high‐density lipoprotein (HDL) levels was investigated in the European Atherosclerosis Research Study (EARS). This is a study of healthy offspring (cases) of fathers who had suffered premature myocardial infarction (MI) before age 55 years (n= 565) and age‐ and sex‐matched controls (n= 1,078) from 12 European countries, divided into 5 regions based on geography and language. The frequency of the polymorphism was not significantly different among the regions and the relative frequency of the rareAallele was similar in cases and controls (0.159 vs. 0.142) combining data from all regions. Individuals with one or moreAallele had significantly higher plasma apo AI levels (P<0.05) than individuals homozygous for theGallele. This effect was consistent in all regions. The data were analyzed separately in males and females. In females, those with one or moreAallele had significantly higher apo AI levels (P= 0.05) than individuals homozygous for theGallele, and this raising effect of theAallele was greater in cases than controls for both apo AI (5.23% vs. 1.56%) and HDL (4.48% vs. 1.89%). In males, theAallele was associated with higher levels of apo AI and HDL, but the effect was much smaller and the differences did not reach statistical significance. In the females, where the effect of theAallele was strongest, the effect on apo AI associated with genotype was evident in non‐smokers, and individuals with one or twoAalleles had 3.6% higher apo AI and 3.14% higher HDL levels than individuals homozygous for theGallele. However, in the female smokers the raising effect of theAallele was greatly reduced (0.56%). Thus genetic variation in the promoter region of the apo AI gene is associated with differences in apo AI and HDL levels in healthy individuals throughout Europe, but the effect is modulated by gender, environmental factors such as smoking, and a family hist

ISSN:0741-0395    

DOI:10.1002/gepi.1370110305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0741-0395    

DOI:10.1002/gepi.1370110306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0741-0395    

DOI:10.1002/gepi.1370110307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0741-0395    

DOI:10.1002/gepi.1370110301

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY