摘要:

In these prospective studies the influence of two different intragastric positions of electrodes and of four different compositions of standardized meals on 24-hour ambulatory pH recording were compared intraindividually in healthy male subjects. Simultaneous pH monitoring in 12 subjects demonstrated a more pronounced postprandial pH elevation in the fundus body compared to the antral area. The intraindividual comparison of an identical diet given on two different days to 10 subjects revealed nearly identical pH profiles. Variations of carbohydrate, protein and fat content of isocaloric meals given in a randomized order did not significantly alter 24-hour intragastric pH profiles. It is concluded from these data that positioning of the pH electrode in the fundus body area is superior to an antral position. 24-hour ambulatory intragastric pH monitoring in man is well reproducible. A strict standardization of the composition of meals is mandatory only for scientific investigations.

ISSN:0257-2753    

DOI:10.1159/000171279

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The intention of the present study was to apply 24-hour intragastric pH monitoring as a diagnostic tool for the detection of pathologic duodenogastric reflux. Therefore, an evaluation system was developed which is able to recognize and quantify specific intraluminal gastric pH patterns regarding their specificity for the disease. pH parameters, stored during 24 h and processed, according to the evaluation system, were obtained for a healthy control population (n = 30) and for patients with pathologic duodenogastric reflux (n = 11). These data were subjected to computerized discriminant analysis to identify pH changes with a high probability of resulting from pathologic duodenogastric reflux. The computer analysis identified 16 discriminating pH parameters to separate a physiologic pH pattern from a 24-hour intragastric pH pattern with a high probability of being associated with pathologic duodenogastric reflux.

ISSN:0257-2753    

DOI:10.1159/000171280

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Gastric potential difference (GPD) is used increasingly as an index of mucosal integrity. The technique for GPD measurement currently employed is however laborious due to the preparation and check of KCl-agarose bridges prior to each experiment. In addition, calculations – usually handmade – are time-consuming and inaccurate. Therefore, a new apparatus allowing continuous recording of basal and drug-induced changes in GPD values was developed. A commercially available 24-hour pH monitor (Proxima Light®, Synectics Medical) was modified in order to allow GPD measurement and recording with subsequent elaboration of data. Furthermore, simultaneous measurement of GPD and intragastric pH through the use of a single stomach probe was made possible. The new method was checked towards the classical PD measuring system employing KCl-agarose bridges. The readings obtained with both systems, either in basal conditions or after aspirin, correlated in a highly significant way. Readings proved to be quite stable with a variation, for 150 consecutive values, of less than 2 mV. With this system the effect of pH modifications, obtained through H2 receptor stimulation and inhibition, on the behaviour of GPD values was investigated in healthy volunteers. Analysis of paired data obtained from these experiments showed an inverse relationship between these two parameters. This suggests that GPD and pH should be measured together, especially during experiments aiming to study drug effects on gastric mucosa. Although the apparatus described was developed for PD measurement and recording in the stomach, it can be used easily for PD measurement across the mucosa of the entire digestive tract, for example in the esophagus, colon or re

ISSN:0257-2753    

DOI:10.1159/000171281

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The normal patterns of pressure activity in the antrum, pylorus and duodenum and associated pH changes were monitored in 9 healthy volunteers under fasted conditions and after ingestion of 300 ml of chocolate milk. The manometric assembly incorporated three side holes in the antrum, four side holes in the duodenum, a sleeve sensor positioned across the pylorus, and pH electrodes situated in the terminal antrum and proximal duodenum. The most common motor pattern recorded under fasting conditions consisted of regular co-ordinated contractions, most of which involved the antrum and duodenum, showed evidence of propagation and was associated with transient decreases in duodenal pH and transient increases in antral pH. Ingestion of milk changed the motor pattern to one that was composed of pressure waves which were confined to the pylorus with few or no pressure waves in the terminal antrum or proximal duodenum. Isolated pyloric pressure waves were gradually replaced by propagated antropyloroduodenal contractions which were associated with transient decreases in duodenal pH. Isolated pyloric pressure waves were not associated with episodes of duodenal acidification under fed conditions.

ISSN:0257-2753    

DOI:10.1159/000171282

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The graphical display of data gained by long-term ambulatory intragastric pH monitoring requires different methods to present (1) the circadian time course of each individual, (2) data from all individuals belonging to the same group, and (3) data from two or more groups in a summary plot. Data reduction is normally required in all three cases; for this purpose, it is advisable to use median values from consecutive time periods, e.g. of 10-20 min each. All data from a total group of comparable individuals may be displayed using a pseudo-3D-graph allowing for easy recognition of interindividual variability. Summary curves from all data of one group may be gained by calculating medians from time-equivalent pH values and plotted together in one graph. The study design should take into consideration that intraindividual reproducibility of intragastric pH metry is excellent, while large variations may occur between individuals. Therefore, repeated measurements in the same individual under the different conditions to be tested are highly recommended. If two measurements are performed in each individual, the data are statistically evaluated using Wilcoxon paired rank test; Friedman rank test and subsequent multiple comparison according to Wilcoxon-Wilcox are proposed in the case of more than two groups. Alternatively, multiple single tests may be used; this procedure, however, requires appropriate correction of the α-error which is best done using the exact versions of the test

ISSN:0257-2753    

DOI:10.1159/000171283

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0257-2753    

DOI:10.1159/000171284

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0257-2753    

DOI:10.1159/000171285

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0257-2753    

DOI:10.1159/000171286

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0257-2753    

DOI:10.1159/000171274

出版商:S. Karger AG    

年代:1990

数据来源: Karger