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1. |
Cigarette Smoking and Gastroesophageal Reflux Disease |
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Digestive Diseases,
Volume 10,
Issue 2,
1992,
Page 61-71
P.J. Kahrilas,
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摘要:
Proposed pathophysiologic mechanisms relating gastroesophageal reflux disease to cigarette smoking are reviewed. Acute experiments have shown that smokers have chronically diminished lower esophageal sphincter (LES) pressure and that periods of smoking are associated with an increased rate of reflux events. Reflux occurred primarily by the ‘abdominal strain mechanism’ rather than by transient LES relaxation. Smoking also caused chronically diminished salivary function that results in prolonged acid clearance time. Thus, smoking potentially increases esophageal acid exposure, both by increases in the number of reflux events, and a prolongation of the esophageal acid clearance t
ISSN:0257-2753
DOI:10.1159/000171345
出版商:S. Karger AG
年代:1992
数据来源: Karger
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2. |
Pathogenic Factors in Inflammatory Bowel Disease |
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Digestive Diseases,
Volume 10,
Issue 2,
1992,
Page 72-84
Paul Pavli,
Peter R. Gibson,
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PDF (2322KB)
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摘要:
Clues from patient and experimental animal studies suggest that events occurring early in the pathogenesis of Crohn’s disease are related to an inability of the immune system to eradicate one or a number of luminal antigens resulting in persistent T cell and macrophage activation. Whether the primary abnormality rests with the nature of the luminal antigen, disturbances of antigen uptake by the mucosa, antigen handling by macrophages, or macrophage-T cell interactions remains unresolved. Given the heterogeneity of clinical presentations and experimental data, Crohn’s disease may be a group of disorders associated with a number of primary defe
ISSN:0257-2753
DOI:10.1159/000171346
出版商:S. Karger AG
年代:1992
数据来源: Karger
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3. |
Antimitochondrial Antibodies in Primary Biliary Cirrhosis and Other Disorders: Definition and Clinical Relevance |
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Digestive Diseases,
Volume 10,
Issue 2,
1992,
Page 85-101
Peter A. Berg,
Reinhild Klein,
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摘要:
The nine different antimitochondrial antibody specificities found in non-hepatic and hepatic disorders are described. Anti-M1 and anti-M7 antibodies are associated with infectious disorders such as syphilis or myocarditis. Anti-M3 and anti-M6 have been found in the course of a drug allergic disease due to Venocuran and iproniazid, and anti-M5 antibodies seem to occur occasionally in some forms of ANA-positive and ANA-negative collagen disorders. The M1- and M7-antigens are biochemically defined as cardiolipin and sarcosine dehydrogenase, respectively. Anti-M2, anti-M4, anti-M8, anti-M9 are associated with primary biliary cirrhosis (PBC). M2 was identified as α-ketoacid-dehydrogenase complex of the inner mitochondrial membrane, anti-M4 as sulfite oxidase, an enzyme of the mitochondrial intermembrane space, and anti-M9 as glycogen phosphorylase, a cytoplasmic enzyme. M8 copurifies with outer mitochondrial membranes derived from pig kidney. Anti-M9 can occur in the absence of anti-M2 while anti-M4 and anti-M8 are always associated with anti-M2. A progressive course of PBC can be predicted with high probability even at early stages of the disease when complement fixing antibodies against M2, M4 and/or M8 are present in patients’ sera. In contrast, the presence of anti-M2/M9 antibodies heralds a benign course. The etiopathogenesis of PBC is still unknown. In PBC contact persons a strong stimulation of naturally occurring mitochondrial antibodies (NOMA) has been observed which was in contrast to the lack of this antibody type in PBC patients. Considering the generally accepted role of those antibodies in protecting individuals from infections, the failure of NOMA production may be a predisposing factor to acquire PBC more easi
ISSN:0257-2753
DOI:10.1159/000171347
出版商:S. Karger AG
年代:1992
数据来源: Karger
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4. |
Giardia lambliaas an Intestinal Pathogen |
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Digestive Diseases,
Volume 10,
Issue 2,
1992,
Page 102-111
David J M. Lewis,
Andrew R. Freedman,
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摘要:
Giardia lamblia are protozoan parasites which cause human intestinal disease. The life cycle has a multiplying intraduodenal trophozoite and an excreted cyst. Infection occurs after cyst ingestion from faecally contaminated water or by direct faecal-oral transmission in situations of poor sanitary standards, but the zoonotic nature of giardiasis is debated. The pathophysiology may arise from enzyme or active transport deficiencies, synergy with intestinal bacteria or an immunopathological process. Diagnosis is made by microscopic identification of cysts or trophozoites in small bowel samples or faeces. Symptoms are acute with diarrhoea (without blood), abdominal cramps, bloating and flatulence. The treatment of choice is either metronidazole or tinidazole. No vaccine or drug prophylaxis exists, and measures to avoid cyst ingestion should be undertaken.
ISSN:0257-2753
DOI:10.1159/000171348
出版商:S. Karger AG
年代:1992
数据来源: Karger
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5. |
Role of the Gastrointestinal Tract in the Regulation of Hydration in Man |
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Digestive Diseases,
Volume 10,
Issue 2,
1992,
Page 112-120
E.M. Gebruers,
W.J. Hall,
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PDF (1453KB)
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摘要:
Research into the role of the gastrointestinal tract in the regulation of hydration has primarily concentrated on its function in the prevention of dehydration. The role of the gut in thirst, in the absorption of fluids and the consequences of diarrhoea are of importance in this respect. The function of the gut in the prevention of overhydration is less well understood. Intake of fluid increases excretion of water by the kidney. Inhibition of arginine vasopressin secretion, activation of renal nerves or hormonal release are possible effector mechanisms in this response.
ISSN:0257-2753
DOI:10.1159/000171349
出版商:S. Karger AG
年代:1992
数据来源: Karger
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