摘要:

Sarcoidosis is an idiopathic granulomatous disease involving one or more multiple organ systems, characterized by the histologic finding of noncaseating epithelioid cell granulomas. The disease has a predilection for intrathoracic structures; the musculoskeletal system is less frequently involved. Most osseous lesions in Sarcoidosis are visible in the small joints of the hands and feet. Articular disease may present as an acute or chronic polyarthritis. Muscle involvement in sarcoidosis is generally asymptomatic. Neurologic findings of the central and peripheral nervous systems may occur in sarcoidosis. Subcutaneous nodules are of diagnostic value. Sarcoid vasculitis may involve small and large blood vessels. Sarcoidosis of the exocrine glands may mimic Sjögren's syndrome. Spontaneous remission of disease often occurs. Treatment with nonsteroidal anti-inflammatory agents, corticosteroids, antimalarials, radiation therapy, and immune-modulating drugs may be beneficial in the treatment of sarcoidosis.

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Pathologic changes in the gastrointestinal tract may be associated with clinical complaints in multiple organs. In some instances, the association between gastrointestinal pathology and extraintestinal disease is so strong that treatment of gastrointestinal disease cures the patient of the extraintestinal complaints. The references in Table 1 show that maintenance of the structural and immunologic barriers of the gastrointestinal tract are vital in determining the general health of the patient, and that the associations between the gut, arthritis, dermatitis, and autoimmune disease are much stronger than may appear at first glance.

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This review presents up-to-date information on many unusual causes of musculoskeletal disorders. These disorders are grouped together because in each there is abnormal accumulation of normal materials or accumulation of abnormal materials in cells or interstitial tissues. Most of these conditions or their associated musculoskeletal manifestations are rare. However, they may present to the adult or pediatric rheumatologist for diagnosis or therapy or both. Gout, because of its prevalence, has been excluded from this review, but it is included briefly in the discussion of the specific arthritides associated with hyperlipidemias. Disorders associated with abnormal lipid storage in which bone and joint pathology occur frequently include Gaucher's disease, histiocytosis-X, and multicentric reticulohistiocytosis. The rarer disorders of this type discussed are Fabry's disease, sea-blue histiocytosis, and Farber's disease. The abnormal accumulation of metal ions in hemochromatosis and in Wilson's disease are probably causative, either directly or indirectly, in the musculoskeletal features of these diseases, while in ochronosis, calcium crystal deposition accompanies the cartilage degradation characteristic of this disease.

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The 1990 literature relating to hematologic disorders in rheumatic disease is reviewed. Two main subject areas of general interest are identified. The anemia of chronic disease has been reviewed and shown to be associated with a variety of medical conditions. Generalized reticuloendothelial hyperplasia associated with heavy-chain disease is a poorly recognized complication associated with rheumatoid arthritis and may be mistaken for underlying sepsis in these patients.

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1991

数据来源: OVID