摘要:

Female Mastomys natalensis were inoculated with a suspension of Klebsiella pneumoniae into the bladder. All animals developed prostatitis without urinary tract infection between the 9th and the 12th day after inoculation. 104––105 CFU of K. pneumoniae per gram prostatic tissue could be cultivated. Histologically acute purulent prostatitis was detected in most cases 6 days after infection. In the follow-up periacinar infiltration predomina

ISSN:0042-1138    

DOI:10.1159/000280397

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The binding of dihydrotestosterone, R 1881 and R 5020 as examined in cytosols of normal, benign hypertrophic and cancerous tissues of the human prostates. Almost all samples obtained by open operation showed high affinity binding to these ligands. Dissociation constants of the binding to these ligands were approximately 10––9M irrespective of the pathological state of the prostates. Maximum binding sites for dihydrotestosterone seemed to be greater in normal tissues than in the pathological ones. However, maximum binding sites for R 1881 and R 5020 were not significantly different among the normal and pathological prostates examined in the present study. Moreover, some correlation was observed between the maximum binding sites for R 1881 and those for R 5020. The samples resected by TUR seemed to be inadequate for analyses of androgen bind

ISSN:0042-1138    

DOI:10.1159/000280398

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The rat prostate was used to investigate cell loss (numeric atrophy) and altered cell proliferation after castration. Cell loss was determined by the proportion of apoptotic bodies. The apoptotic index was considerable and reached a maximum in the coagulating gland on day 2 and in the other prostate lobes between days 4 and 8. Thereafter, cell loss was reduced and finally corresponded to that of control animals. Cell proliferation decreased and soon ceased at all. Androgen administration caused cell increase in all prostate lobes. Following a latent period of 35–40 h, the 3H-labeling index increased with a maximum on day 3. Values then fell and were minimal above control values. Rhythmically interrupted administration of testosterone resulted in a decreased ability to stimulate cell proliferation. This androgen-induced cell proliferation is a useful model for testing cell proliferation of the prostate. The combined determination of cell loss and the cell proliferation, therefore, may be important for the clinical examination of the hormonal responsiveness of prostatic carcinoma

ISSN:0042-1138    

DOI:10.1159/000280399

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of diazoxide and glucagon were studied on the freely draining upper urinary tract and after varying periods of obstruction in dogs. Without obstruction, diazoxide produced longer inactive periods than glucagon and recovery was associated with less retrograde activity. Following obstruction for 5–10 min, 6 and 24 h, diazoxide decreased renal pressure and the effect was greatest when the upper tract was obstructed for the shortest period. Glucagon also produced an overall reduction in pressure after 5–10-min and 6-hour periods of obstruction, but there was an initial rise in pressure after 5–10 min of obstruction. At 24 h there was an increase, but no overall decrease in pressure after glucagon. Diazoxide produced a greater fall in pressure after 5–10 min and 24 h of obstruction, and a faster fall in pressure after 5–10 min and 6 h of obstruction as compared to glucagon. Diazoxide may be a more effective therapeutic agent in the management of ureteral calculus disease than

ISSN:0042-1138    

DOI:10.1159/000280400

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Tissues of human renal cell carcinoma and of its lymph-node metastases were transplanted between the 1st and the 4th passage on 80 nu/nu mice. Growth of tumor was observed in all cases. Chromosomal analyses proved the tumor origin of the transplants. The primary tumor showed two histological patterns: a granular solid cell carcinoma and sarcomatoid elements. The lymph nodes showed only sarcomatoid tissue of the primary tumor. Light-and electron-microscopic examinations showed that the transplanted tumor contained only the sarcomatoid tissue of the original tumor. The solid carcinomatous tissue was not found and, therefore, probably not transplanted. Flow cytometric investigations of the primary tumor revealed two cell populations with a DNA content of 6 and 10.8 pg. Both cell colonies were also discovered in the transplanted tumors as well. The transplants of the primary tumors grew significantly slower than those of the lymph-node metastases. After an initial inert phase, the transplanted tumors grew more rapidly in the male than in the female animals. Neither hematogenous nor lymphatic metastases were observed. After local excision, recurrent tumor development was found in 80% of the experimental animals.

ISSN:0042-1138    

DOI:10.1159/000280401

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

55 patients suffering from voiding disorders associated with primary detrusor instability, have been treated with indomethacin. All patients have remained resistant to conventional medical treatment. 7 patients did not complete the clinical trial. After a 6-week trial period, the patients’ symptom changes and side-effects were assessed. Only 17% of the patients who completed the trial, benefited from the treatment. Side-effects were encountered in 42% of the case

ISSN:0042-1138    

DOI:10.1159/000280402

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Multiple oral doses of alpha-difluoromethyl-ornithine (α-DFMO), 18–24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of α-DFMO in these patients was concluded from the results of serial kidney, liver and bone scintigrams, from the low frequency of a local recurrence of bladder carcinoma and from the survival rate of 4 of 5 patients after 12 months. Increased excretion of hydroxyproline and β2-microglobulin were measured 1 month following α-DFMO treatment suggesting initial tumor necrosis and degradation. Treatment was poorly tolerated with gastrointestinal side effects (e.g. gastritis, vomiting, diarrhea) in all subjects, erythropenia in 2 subjects (associated with thrombocytopenia and leucopenia in 1 subject each), and audiovestibular symptoms in 2 patients. All side effects were reversible and normal function returned 2–4 months after stopping

ISSN:0042-1138    

DOI:10.1159/000280403

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of vinblastine sulfate on the acceptance and growth of a very malignant, human adenocarcinoma of the kidney (RCC1) on nude mice was investigated. Without any treatment, this tumor has an acceptance rate of 100%. Subcutaneously transplanted pieces of tumor, measuring 3 × 3 × 1 mm, commence to grow rapidly 1 week after transplantation and reach a diameter of approximately 2 cm, 6 weeks thereafter. Tumors with a diameter of approximately 2 cm, treated during 6 weeks with vinblastine (0.6 mg/kg/week), continued to grow during treatment and thereafter. However, when these growing, pretreated tumors were transplanted on new experimental animals, they either were not accepted by them or grew very slowly. When animals with tumor transplants were treated for 6 weeks with vinblastine (same schedule as above), beginning on the 1 st day after transplantation, tumor growth was markedly retarded in every case, but only very seldom the tumor was not accepte

ISSN:0042-1138    

DOI:10.1159/000280404

出版商:S. Karger AG    

年代:1981

数据来源: Karger