摘要:

A case of a Sertoli cell tumor of the testicle is reported. Light and electron microscopic findings are discussed, illustrated and compared with other reports of Sertoli cell tumor. The presence of sheets of cells, numerous mitotic figures and questionable abnormality of the periaortic area by CT scan was a cause for concern. The patient is alive and well 2 years after surgery.

ISSN:0042-1138    

DOI:10.1159/000280835

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

An alloplastic spermatocele is implanted to obtain spermatozoa from the epididymis. It is known that, in an alloplastic spermatocele, spermatozoa deteriorate qualitatively and quantitatively as the time interval after implantation increases. 39 Kelâmi-Affeld alloplastic spermatoceles were implanted at the epididymal heads in minipigs. Castration and pathological-anatomical examination of the specimens were performed weeks to months after the operation. It became evident that fibrosis and granulation tissue in the area of the incised epididymal head with occlusion of the opened epididymal tubuli were the causes of aspermia developing in all cases. Apart from normal wound healing, there is additional formation of fibrosis and granulation tissue due to postoperative microbleeding and inflammatory reactions. It may be possible to reduce these complications by microsurgical techniques

ISSN:0042-1138    

DOI:10.1159/000280836

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Urinary continence is guaranteed by many factors. The most important are an intact bladderneck and a normally operating proximal urethra. Predominantly the smooth muscular system is involved. The striated external sphincter is primarily not responsible for continence. At prostatectomy the bladderneck and a great part of the smooth muscles of the proximal urethra inevitably are removed. Postoperatively only a small distal segment of the posterior urethra continues to guarantee continence. This segment may be changed by the growth of the prostate and can be destroyed by an untrained operator. Then, urinary incontinence is the result.

ISSN:0042-1138    

DOI:10.1159/000280837

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Etiology, pathogenesis and optimal therapy of Peyronie’s disease are, 240 years after its first description, still unclear. Diagnosis includes palpation, measurement and exact drawing of the mostly dorsally and laterally located penile induration, photography of erectile deviation, cavernosography and ultrasound as follow-up controls. Pathogenesis of fibrotic stimulation is related to direct local causes such as vascular lesions, microtrauma and hemorrhage and to indirect induction of plasma exudation via autoimmune mechanisms by toxins, infections and vasoactive substances. Symptomatology in 116 of our own patients included the obligatory penile scar, erectile deviation in 75%, pain during erection in 33% and difficult or impossible intercourse in 40%. Radiotherapy in 113 patients led to healing or marked improvement in 44% of cases. In 41% the disease came to a standstill and in 15% of cases symptoms became worse. An analysis of the world literature shows surprisingly a 75% improvement by vitamin E therapy and almost a 60% amelioration by p-aminobenzoic acid and corticoid injections. Favorable results of radiotherapy vary in the literature between 50 and 70%. Reports on these successful treatments include unclear and optimistic criteria in small series and the possible spontaneous standstill or regression of the disease. Indications of operation are erectile pain, impossible invagination and a high degree of penile deviation. Surgical techniques are: (1) Excision of smaller fibrotic segments followed by longitudinal suture of the corpora cavernosa; (2) symmetric and cylindrical resection of both cavernous bodies followed by a watertight reanastomosis after mobilization of the corpus spongiosum; (3) after excision of larger plaques the defect may be covered by autologous material (danger: scar formation, aneurysmatic protrusion, impotence), and (4) hydraulic or semirigid penile prostheses are an ultima ratio. Since there was a 85% improvement or standstill of the disease and little side reactions in 113 of our patients following radiotherapy we recommend it particularly in the early inflammatory phase. An operation might be indicated for patients who do not benefit from this treatment and who show above-mentioned symptom

ISSN:0042-1138    

DOI:10.1159/000280838

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The therapeutic concept of irreversible inhibition of both ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) by alpha-difluoromethylornithine (DFMO) and methylglyoxal bis-guanylhydrazone (MGBG) is based on pathologic activities of these enzymes in tumor tissue. The polyamines putrescine, spermidine and spermine are measured in highest concentration in the prostate of both men and animals, with a significant increase of spermine in benign hyperplasia of the prostate. Patients with metastatic cancer of the prostate have elevated putrescine levels in the 24-hour urine. Treatment with 3 or 1% DFMO or 11 mg/kg MGBG in transplantable human and experimental cancer of the prostate demonstrated a significant anti-growth effect. A combination of DFMO and MGBG is tumor-destructive. The combination of 1% DFMO and 11 mg/kg MGBG distinctly reduces the activity of ODC and SAMDC and significantly lowers the levels of putrescine, spermidine and spermine in the tumor.

ISSN:0042-1138    

DOI:10.1159/000280839

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A case of urachal carcinoma is reported with special reference to the preoperative capability of computerized axial tomography to establish the site of the tumor origin.

ISSN:0042-1138    

DOI:10.1159/000280840

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Arterial plasma renin activity, arterial blood pressure, heart rate and respiratory frequency were measured in 10 patients with chronically distended bladder due to benign prostatic hyperplasia before and after bladder drainage. After suprapubical bladder puncture there was a decrease in all the values. Similar changes were also found in 3 patients with artificially induced acute bladder distension, who did not suffer from infravesical obstruction. A significant correlation was found between the changes of the arterial pressure and arterial plasma renin activity. It is therefore suggested that the renin-angiotensin system might be involved in patients with bladder distension.

ISSN:0042-1138    

DOI:10.1159/000280841

出版商:S. Karger AG    

年代:1982

数据来源: Karger