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| 11. |
Chapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: What is the status of molecular and cell biology approaches relevant to radiation effects assessment? |
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STEM CELLS,
Volume 13,
Issue S1,
1995,
Page 318-322
U. Plappert,
L. Rutzen‐Loesevitz,
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ISSN:1066-5099
DOI:10.1002/stem.5530130739
出版商:John Wiley&Sons, Ltd.
年代:1995
数据来源: WILEY
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| 12. |
Chapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: The use of biological indicators to assess consequences of radiation exposure at the cell system level. Report of a panel discussion under the chairmanship ofW. Gössner |
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STEM CELLS,
Volume 13,
Issue S1,
1995,
Page 323-325
C. Selig,
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PDF (201KB)
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ISSN:1066-5099
DOI:10.1002/stem.5530130740
出版商:John Wiley&Sons, Ltd.
年代:1995
数据来源: WILEY
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| 13. |
Chapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: Biologic indicators of exposure: Are markers associated with oncogenesis useful as biologic markers of effect? |
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STEM CELLS,
Volume 13,
Issue S1,
1995,
Page 326-338
Benedikt L. Ziegler,
Melanie Weiss,
Stefan Thoma,
Christa Lamping,
Theodor M. Fliedner,
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摘要:
AbstractRadiation‐induced molecular and cellular alterations play an important role in the transformation of a normal cell into a cancer cell. However, the basic molecular and cellular alterations upon exposure to ionizing irradiation are still poorly understood. Identification of such alterations would be of importance for the assessment of exposure dose, as well as for the assessment of an exposed individual's risk of developing cancer. Extensive studies of the mechanisms of oncogenesis have led to the identification of altered genes, such as proto‐oncogenes and tumor suppressor genes as well as other genes intimately involved in cellular proliferation and differentiation, that are more or less frequently associated with a variety of human malignancies. It can be assumed that at least some of these mechanisms are associated with radiation‐induced oncogenesis. The longevity of stem cells, particularly those of the hemopoietic system, makes them the prime target cell population to accumulate genetic alterations due to exposure to a variety of agents. Improvements in purification strategies for hemopoietic stem cells, as well as the availability of sensitive techniques such as the polymerase chain reaction (PCR) and flow cytometry analysis, should allow in‐depth studies at the molecular and cellular level after exposure to physical and chemical
ISSN:1066-5099
DOI:10.1002/stem.5530130741
出版商:John Wiley&Sons, Ltd.
年代:1995
数据来源: WILEY
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