摘要:

Intraperitoneal administration of Corynebacterium parvum to BALB/c, C57B1/6 or C3H/HeJ mice lead to the induction of elevated levels of neutral proteinase activity (125I-caseinolytic activity) similar to those observed previously in animals bearing the BCL1 leukemia or the B16-F10 melanoma. Enhanced activity reached a peak at 7–14 days postin-jection of the C. parvum and then gradually returned to normal levels by 20–25 days postin-jection. Increased plasma proteinase activity could be induced by C. parvum whole cells or the pyridine extract residue of C. parvum but not by BCG or the pyridine extract of C. parvum. BCG did not interfere with the induction of elevated levels of activity by C. parvum. Splenectomized animals responded the same as normal mice indicating that the splenomegaly accompanying the onset of increased plasma proteinase activity was not responsible for the changes. Administration of C. parvum via a subcutaneous site rather than intraperitoneally failed to induce systemic changes in proteinase activity while still inducing splenomegaly. Treatment of animals with C. parvum before or after transplantation of the BCL1 leukemia or the B16-F10 melanoma failed to alter the course of the disease or enhance the increased proteinase activity of plasma over that observed in plasma from animals bearing tumors alone. These observations support the hypothesis that the induction of disturbances in plasma proteinase activity in tumor-bearing animals is due to alterations in host systems and that C. parvum, in contrast to BCG, contains components which can mimic the effect of some tumors on host syst

ISSN:1424-8832    

DOI:10.1159/000215562

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Abnormal function of fibrinogen was observed in a 2 5-year-old woman with no symptoms attributable to dysfibrinogenemia. Disturbed polymerization of fibrin monomer was identified, but the release of fibrinopeptide from the purified fibrinogen and the cross-linking by factor XIII were normal. Other abnormal findings included a high value of fibrinogen degradation products, rapid mobility on immunoelectrophoresis and abnormal spot of γ-chain on two-dimensional polyacrylamide gel electrophoresis. Similar abnormalities were also observed among the patient’s family membe

ISSN:1424-8832    

DOI:10.1159/000215563

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A young women affected by Hodgkin’s disease developed chronic autoimmune thrombocytopenic purpura. Splenectomy induced normalization of her platelet count, but hemorrhagic symptoms did not disappear. The patient’s platelets did not aggregate in response to collagen and ADP and the IgG fraction of the patient’s plasma induced the same defect in normal platelets. The women’s IgG recognized glycoproteins IIb and IIIa of normal platelet membranes. Prednisone therapy induced the disappearance of bleeding symptoms and the normalization of platelet agg

ISSN:1424-8832    

DOI:10.1159/000215564

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

We describe a patient with iron-deficiency anemia, thrombocytopenia and paucity of marrow megakaryocytes, in whom the anemia and the thrombocytopenia responded to the administration of iron. Thrombocytopenia recurred, despite maintenance of normal hemoglobin and iron levels and adequate marrow megakaryocytes. Corticoste-roids and splenectomy were required for the control of the thrombocytopenia. In this patient, the initial manifestations of idiopathic thrombocytopenic purpura were modified by the presence of severe iron deficiency. This case strengthens the contention that iron is essential for megakaryopoiesis and thrombopoiesis.

ISSN:1424-8832    

DOI:10.1159/000215565

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000215566

出版商:S. Karger AG    

年代:1987

数据来源: Karger