摘要:

Prothrombin is determined with the aid of a recently developed assay, based on the amidolysis of a chromogenic substrate. The assay proved to be reliable when it was compared with more conventional coagulation assays in the control of oral anticoagulant therapy, both in the therapeutic range and in a case of overdosage. As is the case in coagulation tests, heparin therapy remains a disturbing circumstance. The prothrombin concentration was measured (a) in the plasma of 50 long-term anticoagulated patients, and the results were compared with those obtained with a one-stage coagulation assay and with those obtained with Thrombotest® determinations, and (b) during vitamin K administration in the plasma of a patient with a severe intoxication of a vitamin K antagonist

ISSN:1424-8832    

DOI:10.1159/000214285

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Soluble fibrin monomer complexes (SFMC) have been quantitated in 18 patients with liver cirrhosis by means of plasma gel filtration on an agarose column. The concentration of SFMC (as related to total fibrinogen) was increased in cirrhotic patients. The difference between controls and patients, as well as the difference between compensated and decompensated cirrhotic subjects, was statistically significant. Although these data, together with the results of heparin administration in one reported case, suggest intravascular coagulation, some alternative explanations should also be considered.

ISSN:1424-8832    

DOI:10.1159/000214286

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Subendothelium of blood vessel segments from elderly patients was exposed in a perfusion chamber to citrated blood under arterial blood flow conditions. The resulting platelet adhesion and thrombus formation was assessed morphometrically. The results show that the time course and the extent of platelet adhesion and aggregation were similar to the results obtained previously with subendothelium from rabbit arteries. The extent of surface-induced platelet aggregation was furthermore governed by both the properties of the exposed surface as well as those of the blood perfusate. No significant differences with regard to platelet reactivity were found between veins and arteries and the extent of surface-induced platelet aggregation was rather low.

ISSN:1424-8832    

DOI:10.1159/000214287

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

We studied platelet function and antithrombrin III levels in 30 insulin-dependent diabetic children with no clinically evident vascular complications. 9 were in-patients and 21 were out-patients. The disease had been discovered within the previous 10 years. 25 control subjects of comparable age and body weight were studied simultaneously. Template bleeding time, threshold concentrations of ADP or adrenaline required to induce irreversible platelet aggregation and plasma antiheparin activity (platelet factor 4) did not differ significantly in control and patient groups. In contrast, the immunological levels of plasma antithrombin III were significantly higher in the diabetic group. These results suggest that diabetic children, with no clinical signs of microangiopathy, show no laboratory changes suggesting increased platelet function. The unexpected increase in the antithrombin III level could reflect a very early defense mechanism against activation of the blood clotting system.

ISSN:1424-8832    

DOI:10.1159/000214288

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The adhesiveness of platelets to collagen and glass was studied ex vivo in groups of patients with ischemic heart disease (IHD) and acute myocardial infarction (AMI). Adhesiveness was increased to glass and normal to collagen in both groups of patients. No relation was found between reinfarction rate and adhesiveness in the acute stage of AMI. Electrophoretic mobility of platelets was the same in the AMI patients and a normal control group. It is suggested that the increased ‘retention’ of platelets in IHD patients might be due more to platelet hyperaggregation or to hypersensitivity to platelet aggregating agents than to altered adhesiven

ISSN:1424-8832    

DOI:10.1159/000214289

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Platelet aggregation induced by threshold concentrations of ADP, adrenaline, collagen and Thrombofax® was evaluated in 25 type IIA hypercholesterolemic patients in comparison with 15 control subjects. Malondialdehyde (MDA) formation induced by collagen and thrombin was also studied in a subgroup of 8 patients. In the patient group, irreversible platelet aggregation was induced by significantly lower concentrations of both adrenaline (p < 0.05) and Thrombofax (p < 0.01). MDA formation induced by both aggregating agents was markedly increased (p < 0.01) in type IIA hypercholesterolemic patients

ISSN:1424-8832    

DOI:10.1159/000214290

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The antimetabolite 6-azauridine blocks the de novo synthesis of pyrimidines and causes increased serum levels of several amino acids including homocystine. 6-Azauridine was withdrawn from clinical use for the treatment of psoriasis because of the occurrence of arterial and venous thromboembolic episodes in some psoriatic patients. Utilizing a standard animal model for the recognition of venous and arterial thrombosis, 6-azauridine was demonstrated in this study to cause thrombosis without producing homocystinemia when administered orally or intravenously.

ISSN:1424-8832    

DOI:10.1159/000214291

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000214292

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000214293

出版商:S. Karger AG    

年代:1979

数据来源: Karger